Structural basis for the mechanisms of virus entry into host cells
Project/Area Number |
26713018
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Virology
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Research Institution | Kyushu University |
Principal Investigator |
Hashiguchi Takao 九州大学, 医学(系)研究科(研究院), 准教授 (50632098)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
|
Keywords | 感染症 / ウイルス / 蛋白質 / 構造解析 / 抗体 |
Outline of Final Research Achievements |
To better understand the mechanisms of virus entry, we utilize combined strategies of Structural biology and Virology for mumps virus that causes epidemic parotitis and ebola/marburg virus that cause highly lethal hemorrhagic fever. As the results, we successfully visualized how the viruses enter into host cells at atomic level, which enabled us to better understand a part of the mechanisms of virus entry. These results will illuminate directions toward therapeutics against the viruses.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Trisaccharide containing alpha2,3-linked sialic acid is a receptor for mumps virus2016
Author(s)
Kubota M, Takeuchi K, Watanabe S, Ohno S, Matsuoka R, Kohda D, Nakakita S, Hiramatsu H, Suzuki Y, Nakayama T, Terada T, Shimizu K, Shimizu N, Shiroishi M, Yanagi Y, Hashiguchi T
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Journal Title
Proc Natl Acad Sci USA
Volume: 113
Issue: 41
Pages: 11579-11584
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody2015
Author(s)
Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO
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Journal Title
Cell
Volume: 160
Issue: 5
Pages: 904-912
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Mechanism of human antibody-mediated neutralization of Marburg virus.2015
Author(s)
Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, and Crowe JE Jr.
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Journal Title
Cell
Volume: 160
Issue: 5
Pages: 893-903
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Linear saccharide moiety containing α2,3-linked sialic acid, rather than the sialic acid alone, constitutes a receptor for mumps virus2016
Author(s)
Marie Kubota, Kaoru Takeuchi, Shumpei Watanabe, Shinji Ohno, Rei Matsuoka, Daisuke Kohda, Shin-ichi Nakakita, Hiroaki Hiramatsu, Yasuo Suzuki, Tetsuo Nakayama, Tohru Terada, Kentaro Shimizu, Nobutaka Shimizu, Yusuke Yanagi, Takao Hashiguchi.
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
札幌
Related Report
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[Book] 医学のあゆみ2017
Author(s)
久保田万理恵、橋口隆生、柳雄介
Total Pages
6
Publisher
医歯薬出版株式会社
Related Report
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[Book] 進化を続ける構造生物学2014
Author(s)
松島 正明, 伊中 浩治, 渡邉 信久, 前仲 勝実, 橋口 隆生, 白石 充典, 中川 敦史, 黒木 良太, 斎藤 稔, 津本 浩平, 樋口 芳樹, 裏出 良博
Total Pages
220
Publisher
化学同人
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