Analysis of citrus-derived components focused on the defense of the hyperglycemia-induced cognitive dysfunction
| Project/Area Number |
26750058
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Matsuyama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 柑橘由来成分 / 河内晩柑 / 脳機能障害 / 高血糖 / 脳虚血 / 海馬 / 神経細胞 / タウタンパク質 / 糖尿病 / ミクログリア / タウタンパク |
|---|
| Outline of Final Research Achievements |
Dried peel powder of Kawachi-bankan was orally administered to transient global cerebral ischemia mice, and microglia and astrocyte activation in the hippocampus were suppressed. Moreover, it also inhibited neuronal cell death in the hippocampus.
Kawachi-bankan dried peel powder and its contents auraptene and naringin were orally administered to streptozotocin-induced hyperglycemia mice. These mice showed hyper-phosphorylation of Tau protein in neurons in the hippocampus; however, those sample administration suppressed the Tau phosphorylation.
|
Report
(3 results)
Research Products
(8 results)
-
-
[Journal Article] 3,5,6,7,8,3',4'-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus.2015
Author(s)
Okuyama S., Miyoshi K., Tsumura Y., Amakura Y., Yoshimura M., Yoshida T., Nakajima M., Furukawa Y.
-
Journal Title
Brain Sciences
Volume: 5
Issue: 2
Pages: 118-129
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
