| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Dried peel powder of Kawachi-bankan was orally administered to transient global cerebral ischemia mice, and microglia and astrocyte activation in the hippocampus were suppressed. Moreover, it also inhibited neuronal cell death in the hippocampus.
Kawachi-bankan dried peel powder and its contents auraptene and naringin were orally administered to streptozotocin-induced hyperglycemia mice. These mice showed hyper-phosphorylation of Tau protein in neurons in the hippocampus; however, those sample administration suppressed the Tau phosphorylation.
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