| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Biofuel cells (BFCs) are nature-inspired electrochemical systems. Natural bio-materials (e.g. glucose as the fuel and enzymes as the electrocatalysts) are used under mild conditions at around body temperature at near-neutral pH. We have developed BFCs with hemoglobin (Hb), making it possible for use as body implantable power supplies applied to medical devices such as pacemakers for cardiac resynchronization therapy and deep brain stimulation. In this study, indium tin oxide (ITO) thin films were synthesized on glass plates with different metal molar ratio or different calcination temperature by dip-coating methods and used as bio-electrodes for Hb. The ITO calcined with 773 K with In:Sn=1:1 showed the highest ORR activity of Hb. There are specific active sites for electron transfer between proteins and electrodes. These findings are scientifically very interesting as well as great advantages for practical use of the Hb-ITO system, in particular for body implantable power supplies.
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