| Project/Area Number |
26830067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
|
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| Research Institution | Kinki University (2015)
The University of Tokyo (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | がん幹細胞 / 脳腫瘍 / BMP / 融合遺伝子 / 膠芽腫 / 脳腫瘍幹細胞 / 骨形成因子 / BMP4 |
|---|
| Outline of Final Research Achievements |
We attempted to enhance Bone Morphogenetic Protein (BMP) signal in glioma initiating-cells (GICs) by using of siRNA for Smad6 which is the intracellular inhibitor of BMP signal, we observed that BMP4+siSmad6 dramatically inhibited the maintenance of stemness of GICs. Furthermore, we identified several target genes of BMP4+siSmad6 that had the inhibitory effects of the maintenance of stemness of GICs. Additionally, we discovered several novel fusion genes in GICs by using RNA-Seq of this study, and we found that one of fusion genes identified had the transforming potential and high tumor-forming capacity.
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