gamma-PARCEL

• Project/Area Number: 26860032
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Shuhei MURAYAMA 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 研究員(任常) (50549649)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ソフトナノ粒子 / ハードナノ粒子 / DDS / イメージング / 分析化学 / ゲル / 強度可変ナノ粒子

Outline of Final Research Achievements

In this study, I have developed novel nano material which could become the base of the next-generation chemotherapy and make high quality of life (QOD). The material could be controlled activity of encapsulated anti-cancer drugs by using external signal, as UV, and gamma-ray. Previously, my nano material containing protein is extracted from urine. However, I found that, the nano particle containing with quantum dot (QD) is concentrated in cancer tissue by intravenous injection. And the electroporation at cancer tissue caused longtime accumulation at tumor tissue of the nano particle.

Research Products

• [Journal Article] 光信号による生理活性物質の機能制御法の開発 (2017)
  • Author(s): 村山周平、加藤大
  • Journal Title: 分析化学 Volume: 印刷中
  • Acknowledgement Compliant
• [Journal Article] “Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System” (2016)
  • Author(s): Severina Atanasova, Biliana Nikolova, Shuhei Murayama, Elena Stoyanova, Iana Tsoneva, Zhivko Zhelev, Ichio Aoki, Rumiana Bakalova,
  • Journal Title: Anticancer Res, Volume: 36 Pages: 4601-4606
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Passive and electro-assisted delivery of hydrogel nanoparticles in solid tumors, visualized by optical and magnetic resonance imaging in vivo (2016)
  • Author(s): Rumiana Bakalova, Biliana Nikolova, Shuhei Murayama, Severina Atanasova, Zhivko Zhelev, Ichio Aoki, Masaru Kato, Iana Tsoneva, Tsuneo Saga.
  • Journal Title: Anal. Bioanal. Chem Volume: 408 Issue: 3 Pages: 905-914
  • DOI: 10.1007/s00216-015-9182-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lymph node mapping using quantum dot-labeled polymersomes (2015)
  • Author(s): Rumiana Bakalova, Zhivko Zhelev, Biliana Nikolova, Shuhei Murayama, Iana Tsoneva, Ichio. Aoki, Tsuneo. Saga,
  • Journal Title: Gen. Physiol. Biophys. Volume: 34 Pages: 393-398
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] γ-PARCEL: Control of Molecular Release Using γ-Rays. (2015)
  • Author(s): Shuhei Murayama, Jun-Ichiro Jo , Kazutaka Arai , Fumihiko Nishikido , Rumiana Bakalova , Taiga Yamaya , Tsuneo Saga , Masaru Kato , Ichio Aoki
  • Journal Title: Anal. Chem. Volume: 87 Issue: 23 Pages: 11625-11629
  • DOI: 10.1021/acs.analchem.5b03030
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] “PARCEL : Nano Particles for Imaging Probes” (2016)
  • Author(s): Shuhei Murayama, Rumiana Bakalova, Masaru Kato, Ichio Aoki
  • Organizer: 3rd International Conference on Biomaterials Science in Tokyo
  • Place of Presentation: 東京大学（東京都・文教区）
  • Year and Date: 2016-11-21
  • Int'l Joint Research
• [Presentation] 『γ-PARCEL:放射線応答ナノ粒子によるタンパク質機能制御法』 (2016)
  • Author(s): 村山周平、城潤一郎、新井和孝、ルミアナ バカロバ、加藤大、青木伊知男
  • Organizer: 日本分析化学会第65年会
  • Place of Presentation: 北海道大学（北海道・札幌市）
  • Year and Date: 2016-09-14
• [Presentation] 『nano PARCEL: 多機能ナノキャリア素材としてのナノ粒子ゲル』 (2016)
  • Author(s): 村山周平、加藤大
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府国際コンベンションセンター（大分県・別府市）
  • Year and Date: 2016-05-30
• [Presentation] 『刺激応答性ナノ粒子を用いた生理活性物質の機能制御法の開発と医療応用への展開』 (2016)
  • Author(s): 村山周平
  • Organizer: 日本薬学会第136年会物理系薬学部会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] “γ-PARCEL: γ-Ray Responsible nano Particle for the Molecular Control (2015)
  • Author(s): Shuhei Murayama, Kazutaka Arai, Fumihiko Nishikido, Rumiana Bakalova, Taiga Yamaya, Tsuneo Saga, Masaru Kato, Ichio Aoki
  • Organizer: 2nd COINS International Symposium
  • Place of Presentation: TOKYO
  • Year and Date: 2015-11-24
  • Int'l Joint Research
• [Presentation] γ-PARCEL: MOLECULAR CONTROLLED RELEASE USING γ-RAYS (2015)
  • Author(s): Shuhei Murayama, Kazutaka Arai, Fumihiko Nishikido, Rumiana Bakalova, Taiga Yamaya, Tsuneo Saga, Masaru Kato, Ichio Aoki
  • Organizer: 75th FIP World congress of pharmacy and pharmaceutical Sciences 2015（第75回国際薬剤師・薬学連合国際会議）
  • Place of Presentation: Dusseldorf, Germany
  • Year and Date: 2015-09-28
  • Int'l Joint Research
• [Presentation] PARCEL～柔らかナノゲルとハードナノゲル～ (2015)
  • Author(s): 村山周平、城潤一郎、Biliana Nikolova、Rumiana Bakalova、佐賀恒夫、加藤大、青木伊知男
  • Organizer: 第28回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 2015-08-21
• [Presentation] 放射線応答性ナノ粒子によるタンパク質機能制御 (2015)
  • Author(s): 村山周平 新井和孝 錦戸文彦 BAKALOVA Rumiana 山谷泰賀 佐賀恒夫 加藤大 青木伊知男
  • Organizer: 日本分子イメージング学会
  • Place of Presentation: 東京と江戸川区
  • Year and Date: 2015-05-20 – 2015-05-21
• [Presentation] 放射線応答性ナノ粒子によるタンパク質機能制御 (2015)
  • Author(s): 村山周平、新井和孝、錦戸文彦、Rumiana Bakalova、山谷泰賀 、佐賀恒夫、加藤大、 青木伊知男
  • Organizer: 第10回日本分子イメージング学会総会･学術集会
  • Place of Presentation: 船堀
  • Year and Date: 2015-05-20
• [Presentation] γPARCEL：放射線による生体内深部での生理活性物質の機能制御法 (2015)
  • Author(s): 村山 周平 新井 和孝 錦戸 文彦 Rumiana BAKALOVA 加藤 大 佐賀 恒夫 青木 伊知男
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-03-25 – 2015-03-28
• [Remarks] 拓く研究人（１６２）放射線医学総合研究所機能分子計測チーム研究員・村山周平氏
  • URL: https://www.nikkan.co.jp/articles/view/00428343/0/106