| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Although it is well known that many viruses can cause severe diseases, existing drugs against viruses are not sufficient and development of novel anti-virus drugs is required. Previously, I found that 25-hydroxycholesterol (25OHC) can inhibit virus replication without affecting on the viability of host cells. In this study, I investigated the molecular mechanism how 25OHC is recognized by the host cells, and how 25OHC induces the expression of specific stress-related genes. These results suggest that 25OHC may be a promising target for development of a novel anti-virus drug.
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