Ribosomal RNA gene mutation in Human Malignancies
| Project/Area Number |
26860233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Niigata University |
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Principal Investigator |
OHASHI Riuko 新潟大学, 医歯学系, 助教 (20447600)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リボソーム遺伝子 / LXRα / 肺癌 / 遺伝子変異 / 遺伝子多型 / リボソームDNA / LXR / 核内受容体 |
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| Outline of Final Research Achievements |
In this study, we identified new somatic mutations in proximity to ribosomal RNA gene transcription start site in two cases (5%) of 40 lung cancer patients by PCR-direct sequence method. To determine the relationship between clinicopathological significance and ribosomal RNA gene mutation, sequence analysis of more patients are ongoing.
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Report
(3 results)
Research Products
(2 results)
