| Project/Area Number |
26860365
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
ARIOKA YUKO 名古屋大学, 医学部附属病院, 特任助教 (10709497)
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| Research Collaborator |
YAMADA Yasuhiro 京都大学, iPS細胞研究所, 教授
ITO Hiroyasu 岐阜大学, 医学系研究科, 准教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | iPS細胞 / 体細胞初期化過程 / 組織幹細胞 / 組織特異性 / 体細胞初期化 |
|---|
| Outline of Final Research Achievements |
It remains unclear whether the reprogramming process shows the opposite direction of the development (differentiated cells → tissue stem cells/progenitor cells → iPS cells). To address this, we investigated the reprogramming process using hair follicles. Some cells transiently exhibited the hair follicle stem cell marker (Lgr5); however, the Lgr5-positive cells were unlike native ones. On the other hand, we found that the Lgr5-positive cells were efficiently converted into iPS cells.
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