The mechanism for activation of a spinal microglia induced by multiple stress loading
| Project/Area Number |
26860381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Nagoya University |
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Principal Investigator |
YASUI MASAYA 名古屋大学, 全学技術センター(医学), 技術専門職員 (10723695)
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| Research Collaborator |
KIYAMA Hiroshi
MIZUMURA Kazue
TOKIZANE Kyohei
MENJO Yuki
YOSHIMURA Takashi
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ストレス / 疼痛 / ミクログリア / 線維筋痛症 / 慢性疲労症候群 / 病的疼痛 / 疲労 / 脊髄 / DRG / 固有感覚ニューロン |
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| Outline of Final Research Achievements |
The present study addressed whether the nonphysiological pain was occurred in different two stress models. In the result, we demonstrated that CFS and FM models elicited mechanical allodynia and muscular hyperalgesia. Furthermore no signs of inflammation and injury incidents were observed in both the plantar skin and leg muscles. However, microglial accumulation and activation were observed in L4-L6 dorsal horn of CFS and FM model rats. To evaluate an implication of microglia in pain, minocycline was intrathecally administrated in CFS model rats. Minocycline significantly attenuated continuous multiple stresses induced mechanical hyperalgesia and allodynia. These results indicated that activated microglia were involved in the development of abnormal pain in CFS animals, suggesting that the pain observed in CFS and FM patients may be partly caused by a mechanism in which microglial activation is involved.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents2014
Author(s)
Akagi T, Matsumura Y, Yasui M, Minami E, Inoue H, Masuda T, Tozaki-Saitoh H, Tamura T, Mizumura K, Tsuda M, Kiyama H, Inoue K
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 2
Pages: 172-176
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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