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Carnitine supplementation improves depressive mode in uremic men with hemodialysis

Research Project

Project/Area Number 26860487
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionKurume University

Principal Investigator

Sakai Kazuko  久留米大学, 医学部, 助教 (90597387)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords血液透析 / LOH症候群 / カルニチン / うつ病 / 透析 / 加齢男性更年期症候群 / アルツハイマー型認知症
Outline of Final Research Achievements

Depression contributes to decrease in quality of life in male hemodialysis (HD) patients. We have recently reported that carnitine deficiency is associated with degree of depression in male HD patients. Therefore, we examined whether carnitine supplementation improved depressive mode in these patients. Sixteen male and ten female HD patients were enrolled in this study. We examined whether depression mode was improved by administration of L-carnitine by PO (900mg/day) or IV . Status of depression was evaluated by questionnaires using self-rating depression scale (SDS).Levels of all the carnitine fractions were significantly increased by L-carnitine supplementation in HD patients. SDS was significantly improved by L-carnitine administration for 3 month in male HD patients.The observations suggest that L-carnitine therapy improved depression mode, thus supporting the clinical utility of administration of L-carnitine for the treatment of male patients on HD.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients.2015

    • Author(s)
      Fukami K, Yamagishi S, Sakai K, Kaida Y, Yokoro M, Ueda S, Wada Y, Takeuchi M, Shimizu M, Yamazaki H, Okuda S.
    • Journal Title

      J. Cardiovasc. Pharmacol.

      Volume: 65. Issue: 3 Pages: 289-295

    • DOI

      10.1097/fjc.0000000000000197

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of switching from oral administration to intravenous injection of L-carnitine on lipid metabolism in hemodialysis patients2014

    • Author(s)
      Fukami K, Yamagishi S, Sakai K, Nasu M, Okuda S
    • Journal Title

      Clin Kidney J

      Volume: 7 Issue: 5 Pages: 470-474

    • DOI

      10.1093/ckj/sfu082

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 血液透析患者における抑うつに対するL-カルニチン補充療法の効果2016

    • Author(s)
      黒川佑佳
    • Organizer
      平成28年度日本透析学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-06-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血液透析患者における抑うつに対するL-カルニチン補充療法の効果2016

    • Author(s)
      矢野淳子
    • Organizer
      平成28年度第8回福岡県医学会総会
    • Place of Presentation
      福岡県医師会
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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