| Project/Area Number |
26860521
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
MITSUI Retsu 名古屋市立大学, 大学院医学研究科, 講師 (90434092)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 血管平滑筋 / 平滑筋 / 微小血管 / 自発収縮 / 自律神経 / 細静脈 / 細動脈 / 内皮細胞 / 一酸化窒素 / 交感神経 / ペリサイト / NO / PDE5 / カルシウムイメージング / 自動能 / 消化管 |
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| Outline of Final Research Achievements |
The venular mural cells (vascular smooth muscle cells and pericytes) connected each other via gap junctions in the stomach periodically exhibited synchronous, spontaneous rise in intracellular Ca2+ concentration followed by the rhythmic spontaneous constrictions of venules. These activities depended on both spontaneous Ca2+ release from intracellular Ca2+ store and L-type Ca2+ channel-mediated Ca2+ influx. Although endothelial nitric oxide (NO) potentially inhibited spontaneous constrictions, the cGMP degrading enzyme phosphodiesterase 5 (PDE5) continuously inhibited NO-cGMP signalling in mural cells to maintain spontaneous constrictions. The spontaneous constrictions may prevent blood stagnation during prolonged gastric wall distension by ingested food. On the other hand, a sympathetic nerve-mediated sustained venular constriction may be important for acutely draining blood from the gastrointestinal tract to other organs such as the heart and brain during exercise or haemorrhage.
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