| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Outline of Final Research Achievements |
Sleep disturbance (SD), especially sleep fragmentation, is a common symptom among patients of neurodegenerative diseases. Although recent epidemiological studies have suggested a bidirectional relationship between SD and neurodegeneration, whether SD similar to the patients aggravates neurodegeneration remains to be elucidated mainly due to technical limitations in producing relevant animal models. Here we successfully induced chronic sleep fragmentation in a mouse model of neurodegenerative disease and demonstrate that the severity of brain pathology in this mouse line exhibits a significant positive correlation with the extent of sleep fragmentation.
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