| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
I examined roles of receptor activator of NF-kappa B (RANK) in humoral immune response in the research program. Our results suggest that the interaction between follicular dendritic cells (FDCs) and follicular helper T (Tfh) cells would promote T cell-dependent humoral immunity. In addition, I performed global gene expression analysis with stromal cell subsets using next generation sequencing. The assay provided unique gene expression patterns of each stromal cell subsets and revealed RANK receptor was highly expressed in stroma cells especially lymphatic endothelial cell (LEC) and/or LEC-like cells. The finding indicates that humoral immune response could be regulated by RANK expressed by these stromal cells. In addition, our gene expression data of stromal cells is useful information to understand role and function of stromal cells in host defense and immunopathological diseases.
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