Detection of ovomucoid-specific low-affinity IgE in infants
Project/Area Number |
26860806
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | The University of Tokushima |
Principal Investigator |
Kamemura Norio 徳島大学, 生物資源産業学部(仮称)設置準備室, 助教 (10632656)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 低親和性IgE / 低親和性特異的IgE / 抗原特異的IgE / アレルギー |
Outline of Final Research Achievements |
Immunoglobulin E (IgE) plays key roles in type I hypersensitivity in allergic individuals. We previously demonstrated the detection of antigen-specific low-affinity IgE in cord blood, but not after birth. We investigated the presence of low-affinity IgE during the infants’ early life.We found allergen-specific low-affinity sIgE in human infant peripheral blood even after birth.Further studies are needed to elucidate the roles of low-affinity IgE and of their affinity maturation to high-affinity after birth.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Application of moisturizer to neonates prevents development of atopic dermatitis.2014
Author(s)
Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, Shigematsu Y, Yoshida K, Niizeki H, Motomura K, Sago H, Takimoto T, Inoue E, Kamemura N, Kido H, Hisatsune J, Sugai M, Murota H, Katayama I, Sasaki T, Amagai M, Morita H, Matsuda A, Matsumoto K, Saito H, Ohya Y.
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Journal Title
The Journal of allergy and clinical immunology.
Volume: 134
Issue: 4
Pages: 824-830
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 第64回日本アレルギー学会学術大会2015
Author(s)
亀村典生, 高島美和, 森田英明, 松本健治, 斎藤博久, 木戸博
Organizer
新生児、乳児便中の抗原特異的SIgAの新測定法
Place of Presentation
グランドプリンスホテル高輪 (東京都品川区)
Year and Date
2015-05-26
Related Report
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