Development of dose-guided radiotherapy technique using cone-beam CT

• Project/Area Number: 26860965
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Takao Seishin 北海道大学, 大学病院, 助教 (10614216)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 陽子線治療 / コーンビームCT

Outline of Final Research Achievements

Proton beam therapy requires highly-precise image guidance in patient setup to ensure accurate dose delivery. Cone-beam CT (CBCT) is expected to play an important role to reduce uncertainties in patient setup. Particularly in particle therapy, the methodology to evaluate setup error considering dose distribution is to be established. This study aimed to develop the intelligent patient setup technique considering not only geometrical position of the patients but also dose distribution. Quantitative performance evaluation of CBCT image quality and mechanical accuracy of the system was performed. Accuracy of three-dimensional images registration between CBCT and reference CT images was evaluated. Moreover, the method to evaluate dose distribution under possible setup error was developed. Through these techniques feasibility of dose-guided radiotherapy has been established.

Research Products

• [Journal Article] Intrafractional baseline shift/drift of lung tumor motion during gated radiotherapy with a real-time tumor-tracking system (2016)
  • Author(s): Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Kenneth Lee Sutherland, Ryusuke Suzuki, Hiroki Shirato, Shinichi Shimizu
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: 94(1) Issue: 1 Pages: 172-180
  • DOI: 10.1016/j.ijrobp.2015.09.024
  • Peer Reviewed
• [Presentation] 陽子線治療装置回転ガントリー搭載型二軸X線撮影装置を用いたCBCT時短撮影の実現可能性検討 (2016)
  • Author(s): 高尾聖心、清水伸一、宮本直樹、松浦妙子、松崎有華、山田貴啓、藤井祐介、藤井孝明、梅垣菊男、白土博樹
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-14
• [Presentation] Feasibility study of fast cone-beam CT image acquisition with a dual-orthogonal fluoroscopic imaging system equipped on rotating gantry of proton beam therapy system (2015)
  • Author(s): Seishin Takao, Shinichi Shimizu, Takahiro Yamada, Naoki Miyamoto, Taeko Matsuura, Yuka Matsuzaki, Yusuke Fujii, Toru Umekawa, Rika Baba, Kikuo Umegaki, Hiroki Shirato
  • Organizer: 54th Annual Conference of the Particle Therapy Co-Operative Group
  • Place of Presentation: Manchester Grand Hyatt （San Diego, California）
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] 陽子線治療装置ガントリー搭載型コーンビームCT装置のコミッショニング (2015)
  • Author(s): 高尾聖心、清水伸一、宮本直樹、松浦妙子、松崎有華、山田貴啓、藤井祐介、松尾勇斗、梅垣菊男、白土博樹
  • Organizer: 第109回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-04-16
• [Presentation] Commissioning of the On-board Cone-beam CT System Equipped on the Rotating Gantry of a Proton Therapy System (2014)
  • Author(s): S. Takao, S. Shimizu, N. Miyamoto, T. Matsuura, C.Toramatsu, H. Nihongi, T. Yamada, K. Matsuda, T. Sasaki, Y. Nagamine, R. Baba, T. Umekawa, K. Umegaki, H. Shirato
  • Organizer: 2014 AAPM Annual Meeting
  • Place of Presentation: Austin Convention Center （Austin, USA)
  • Year and Date: 2014-07-20 – 2014-07-24