| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Our previous research showed local C-ion treatment was able to repress lung metastasis from distal (non-irradiated) tumor in Colon-26-bearing BALB/c model. In this study, the universal of this phenomenon had been verified by using LM8-bearing C3H/He model. Similar to Colon-26-bearing BALB/c model, lung metastasis from distal tumor was significantly decreased in the mice treated with C-ion irradiation. However, the metastasis suppression from distal tumor was not observed after C-ion irradiation in Colon-26-bearing BALB/c-nu/nu model. These results indicate that C-ion local irradiation has ability to suppress metastasis from distal tumor by whole body immune system. In addition, the C-ion and photon had been compared as a resource for this phenomenon. The result showed that both C-ion and X-ray irradiation significantly repressed lung metastasis from distal tumor.
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