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Innovation of cancer therapies based on anti-aging klotho gene

Research Project

Project/Area Number 26861129
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionTokyo Medical University

Principal Investigator

KUDO YUJIN  東京医科大学, 医学部, 助教 (80623800)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsklotho / アンチエイジング / 肺癌 / 予後 / 再発 / 補助化学療法 / タキサン系抗癌剤
Outline of Final Research Achievements

We reported that the klotho gene, which was an anti-aging gene, affected the prognosis of lung cancer patients. We also found that a high expression of the klotho protein could markedly increase the apoptotic response of cancer cells to taxanes, anti-cancer agents. The expression of klotho protein was not associated with those of class III β-tubulin and P glycoprotein. Klotho expression was a significant prognostic factor in patients with pN2 lung cancer, and those without klotho expression had worse survival than those with klotho expression. The potential for high-grade malignancy was also investigated in patients who underwent surgical resection for lung cancer or those with postoperative recurrence.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Association between high-resolution computed tomography findings and the IASLC/ATS/ERS classification of small lung adenocarcinomas in Japanese patients.2015

    • Author(s)
      Kudo Y, Matsubayashi J, Saji H, Akata S, Shimada Y, Kato Y, Kakihana M, Kajiwara N, Ohira T, Nagao T, Ikeda N.
    • Journal Title

      Lung Cancer

      Volume: 90 Issue: 1 Pages: 47-54

    • DOI

      10.1016/j.lungcan.2015.07.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prognostic factors for survival after recurrence in patients with completely resected lung adenocarcinoma: important roles of epidermal growth factor receptor mutation status and current staging system2015

    • Author(s)
      Yujin Kudo, Yoshihisa Shimada, Hisashi Saji, Yasufumi Kato, Koichi Yoshida, Jun Matsubayashi, Seisuke Nagase, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Toshitaka Nagao, Norihiko Ikeda
    • Journal Title

      Clinical Lung Cancer

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 小型肺腺癌におけるHRCT所見とIASLC/ATS/ERS分類を用いた臨床病理学的因子の関係2015

    • Author(s)
      工藤勇人,松林純,赤田壮一,嶋田善久,雨宮亮介,加藤靖文,垣花昌俊,梶原直央,大平達夫,池田徳彦
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Klotho expression induces apoptosis of cancer cells against anti-cancer agents2015

    • Author(s)
      Yujin Kudo, Jitsuo Usuda, Junichiro Osawa, Shotaro Ono, Sachio Maehara, Keishi Ohtani, Yasufumi Kato, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
    • Organizer
      3rd International Conference of Federation of Asian Clinical Oncology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肺扁平上皮癌においてリンパ節転移が予後に与える影響2015

    • Author(s)
      工藤勇人、嶋田善久、雨宮亮介、前田純一、吉田浩一、加藤靖文、萩原優、垣花昌俊、梶原直央、 大平達夫、池田徳彦
    • Organizer
      第68回日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Adjuvant chemotherapy for stage IB non-small cell lung cancer based on blood vessel invasion2015

    • Author(s)
      Yujin Kudo, Yoshihisa Shimada, Ryosuke Amemiya, Yasufumi Kato, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
    • Organizer
      29th European Association for Cardio-Thoracic Surgery Annual Meeting
    • Place of Presentation
      Amsterdam, Netherland
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of lymph node involvement on survival in patients with completely resected pulmonary squamous cell carcinoma2015

    • Author(s)
      Yujin Kudo, Yoshihisa Shimada, Ryosuke Amemiya, Junichi Maeda, Koichi Yoshida, Yasufumi Kato, Masaru Hagiwara, Jun Matsubayashi, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
    • Organizer
      16th IASLC World Conference on Lung Cancer
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation between high-resolution computed tomography findings and IASLC/ATS/ERS classification of small lung adenocarcinomas in Japanese patients2015

    • Author(s)
      Yujin Kudo, Jun Matsubayashi, Yoshihisa Shimada, Soichi Akata, Yasufumi Kato, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Toshitaka Nagao, Norihiko Ikeda
    • Organizer
      2015 ASCO Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 30mm以下の肺腺癌における術前HRCT所見とIASLC/ATS/ERS分類を用いた臨床病理学的因子の関係2015

    • Author(s)
      工藤勇人、嶋田善久、雨宮亮介、加藤靖文、垣花昌俊、梶原直央、大平達夫、池田徳彦
    • Organizer
      第32回日本呼吸器外科学会総会
    • Place of Presentation
      高松
    • Year and Date
      2015-05-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 若年者肺癌切除例の臨床病理学的特徴と予後2014

    • Author(s)
      工藤勇人,嶋田善久,河口洋平,大谷圭志,垣花昌俊,加藤靖文,梶原直央,大平達夫,池田徳彦
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Impact of EGFR mutation status on survival after recurrence in patients with completely resected lung adenocarcinoma2014

    • Author(s)
      Kudo Y, Shimada Y, Kato Y, Yoshida K, Osawa J, Maehara S, Maeda J, Matsybayashi J, Kakihana M, Kajiwara N, Ohira T, Ikeda N
    • Organizer
      2014 IASLC Asia Pacific Lung Cancer Conference
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2014-11-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺腺癌切除後再発とEGFR遺伝子変異の関係2014

    • Author(s)
      工藤勇人,嶋田善久,垣花昌俊,大谷圭志,加藤靖文,佐治久,梶原直央,大平達夫,池田徳彦
    • Organizer
      第67回日本胸部外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-03
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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