Antitumor effect of Group-specific component derived Macrophage Activating Factor (GcMAF) on glioblastoma
Project/Area Number |
26861153
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | The University of Tokushima |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 脳腫瘍 / グリオブラストーマ / GcMAF / マクロファージ / TNFα / 超音波療法 / 5-ALA / グリオブラストーマ / 免疫賦活 |
Outline of Final Research Achievements |
Macrophages are important phagocytic cells that internalizeand destroy pathogens and release cytokines. They can infiltrate into tumors and are found in most tumor sites. Gc protein-derived macrophage-activating factor (GcMAF) can be used as an important immunotherapy for cancer treatment. Several studies reported that GcMAF exerts anti-tumor effects by inducing direct inflammatory necrosis inside tumors, producing antitumor immunity via antigen-presenting cells to prevent immune escape in a variety of deep and superficial tumors. Unfortunately, we could not demonstrate the anti-rumor effect on GBM in this study. However, we found the adjuvant effects of GcMAF and noticed the importance of the timing of the therapy with GcMAF. Recent other study reported that the combination of sonodynamic therapy with GcMAF may be capable of controlling tumor progression. We need further experimental studies to examine the availability of GcMAF for GBM patients
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma2015
Author(s)
Hara K, Kageji T, Mizobuchi Y, Kitazato KT, Okazaki T, Fujihara T, Nakajima K, Mure H, Kuwayama K, Hara T, Nagahiro S
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Journal Title
Cancer Lett
Volume: 356
Issue: 2
Pages: 496-505
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time2015
Author(s)
Abe T, Mizobuchi Y, Nakajima K, Otomi Y, Irahara S, Obama Y, Majigsuren M, Khashbat D, Kageji T, Nagahiro S, Harada M
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Journal Title
Springerplus
Volume: 4
Issue: 1
Pages: 88-88
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma.2015
Author(s)
Hara K, Kageji T, Mizobuchi Y, Kitazato KT, Okazaki T, Fujihara T, Nakajima K, Mure H, Kuwayama K, Hara T, Nagahiro S
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Journal Title
Cancer Lett
Volume: 356
Pages: 496-505
Related Report
Peer Reviewed
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[Presentation] Down-regulation of MDR1 by DKK3 attenuates chemoresistance to temozolomide, and potentiates its anti-tumor effects2015
Author(s)
T.Fujihara, T.Kageji, Y.Mizobuchi, R.Otsuka K.Kitazato, K.Hara, K.Shono, K.Nakajima H.Mure, K.Kuwayama, S.Nagahiro
Organizer
20th Annual Socientific Meeting and Education Day of the Society for Neuro-Oncology
Place of Presentation
Texas,USA
Year and Date
2015-11-19
Related Report
Int'l Joint Research
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