| Project/Area Number |
26861226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Research Collaborator |
HATTORI Mizuki 富山大学, 附属病院, 助教
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アスタキサンチン / 敗血症 / 全身炎症反応症候群 / 抗酸化作用 / 酸化ストレス / 5-FU誘発腸炎 / 炎症性腸炎 / SIRS / サイトカイン / 抗酸化 / 全身性炎症反応症候群 / 急性肺障害 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
Systemic inflammatory response syndrome (SIRS) is the leading cause of death intensive care units. Oxidative stress plays as important role in SIRS. The aim of this study was to evaluate the effects of Astaxanthin, that is one of antioxidants, in SIRS. In 5-FU induced enteritis mice, the number of intestinal crypt cells was deceased and apoptotic cells was increased. Both in enteritis mice and TNF-alfa stimulated HCT 116 cells, expression of inflammatory cytokines and ROS (reactive oxygen species) increased. In contrast, in Astaxanthin + 5-FU group , the number of intestinal crypt cells was inceased and apoptotic cells was less than 5-FU group, and expression of inflammatory cytokine reduced. In Astaxanthin + TNF-alfa group, expression of ROS was less than TNF-alfa stimulated HCT 116 cells group. The protective effects of Astaxanthin are likely attributable to the decrease in oxidative stress.
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