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The role of 5-HT3 receptor in bladder sensation

Research Project

Project/Area Number 26861267
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

Takezawa Kentaro  大阪大学, 医学部附属病院, 医員 (90648015)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords過活動膀胱 / 5-HT3受容体 / 膀胱炎 / 膀胱
Outline of Final Research Achievements

This study investigated the role of serotonin type 3 receptor (5-HT3 receptor) in bladder sensation. I found that 5-HT3 receptor is abundantly expressed on primary bladder afferent nerves, activation of 5-HT3 receptor causes bladder hyperactivity, and blockade of 5-HT3 receptor inhibits the cystitis-induced bladder hyperactivity in mice. These findings indicate the novel mechanisms of bladder hyperactivity mediated by 5-HT3 receptor, and suggest that 5-HT3 receptor may be a potential therapeutic target for overactive bladder syndrome.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 5-HT3受容体を介した新たな膀胱知覚亢進機構2016

    • Author(s)
      竹澤健太郎
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-23
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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