Study on endolymphatic hydrostatic pressure regulating function of endolymphatic sac

Research Project

Project/Area Number	26861387
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Kagawa University
Principal Investigator	Inamoto Ryuhei 香川大学, 医学部附属病院, 助教 (50581047)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000) Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000) Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000) Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Keywords	内リンパ嚢 / 蝸牛 / 前庭 / カテコールアミン / 内リンパ静水圧 / 外リンパ静水圧 / 前庭・半規管 / 内リンパ / 外リンパ / 静水圧 / イソプロテレノール / 蝸牛内リンパ圧 / 蝸牛外リンパ圧 / 前庭内リンパ圧 / 前庭外リンパ圧
Outline of Final Research Achievements	The hydrostatic pressures of endolymph and perilymph in the ampulla and cochlea were similar in magnitude. Isoproterenol significantly increased hydrostatic pressure of ampullar and cochlear endolymph and perilymph with no change in the ampullar endolymphatic potential and endocochlear potential, respectively. The isoproterenol-induced maximum change of endolymphatic hydrostatic pressure in ampulla was significantly (p < 0.01) smaller than that in the cochlea. In ears with an obstructed endolymphatic sac, the action of isoproterenol on endolymphatic hydrostatic pressure in the ampulla disappeared like that in the cochlea. Isoproterenol elevates endolymphatic hydrostatic pressure in different manner between the vestibule and the cochlea.