Development of new dental pulp capping material applied effect of reprograming of dental pulp cells by TNF-alpha
| Project/Area Number |
26861640
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | The University of Tokushima |
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Principal Investigator |
UEDA Mayu 徳島大学, 大学病院, 助教 (20625719)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 歯髄細胞 / TNF-α / 幹細胞化 / 幹細胞 / TN F-α |
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate of the mechanism of dentin reprogramming of human dental pulp cells mediated by TNF-α, and identify the factor participating in the reprogramming.
Human DPCs were isolated from patients who agreed with our study in accordance with a previously reported method. We collected protein from dental pulp cells which were untreated and stimulated by TNF-α.Thereafter we analyzed the protein used an antibody array, expression of p38MAPK, TRAF1 was increased.
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Report
(3 results)
Research Products
(2 results)
