The development of oral cancer treatment due to the introduction of HDAC inhibitors using sonoporation method

Research Project

Project/Area Number	26861745
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Kyushu Dental College
Principal Investigator	Takahashi Osamu 九州歯科大学, 歯学部, 助教 (50611092)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	口腔癌 / ソノポレーション / ナノバブル / Drug Delivery System
Outline of Final Research Achievements	In recent years, various studies have been developed for cancer chemotherapy. However the method satisfactory in terms of transfer efficiency of the drug and safety has not been established. Therefore we focused on the microbubbles as efficient drug delivery to the cancer and less damage to the normal tissue. Transduction efficiency for human gingival squamous carcinoma cells, where using antibodies and microbubbles was 18%. This method inhibited cancer cell proliferation.