The development of oral cancer treatment due to the introduction of HDAC inhibitors using sonoporation method
| Project/Area Number |
26861745
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔癌 / ソノポレーション / ナノバブル / Drug Delivery System |
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| Outline of Final Research Achievements |
In recent years, various studies have been developed for cancer chemotherapy. However the method satisfactory in terms of transfer efficiency of the drug and safety has not been established. Therefore we focused on the microbubbles as efficient drug delivery to the cancer and less damage to the normal tissue.
Transduction efficiency for human gingival squamous carcinoma cells, where using antibodies and microbubbles was 18%. This method inhibited cancer cell proliferation.
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Report
(3 results)
Research Products
(1 results)
