Functional analysis of protein disulfide isomerase P5 as anti-cancer target
| Project/Area Number |
26870287
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
HORIBE TOMOHISA 京都大学, 医学(系)研究科(研究院), 講師 (20467468)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ケミカルバイオロジー / タンパク質 / 分子シャペロン / 生化学 |
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| Outline of Final Research Achievements |
We performed the functional analysis of protein disulfide isomerase (PDI) P5 in cancer cells using inhibitors to reductase activity of P5, which we previously screened and identified using a chemical compound library. It was found that one of these inhibitors could decrease the secretion levels of soluble MICA from cancer cells. We also examined the effect of the inhibitors on the cancer cells viability, and found that the inhibitors had cytotoxic activity to cancer cells.
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Report
(3 results)
Research Products
(6 results)
