Development of a distortion and intensity inhomogeneity correction system for the precise longitudinal brain morphometry using MRI

• Project/Area Number: 26870523
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology; Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: Yamashita Fumio 岩手医科大学, 医学部, 講師 (90628455)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: MRI / 歪み補正 / 信号むら補正 / 縦断解析 / 脳体積解析 / ファントム

Outline of Final Research Achievements

A phantom to correct geometric distortion and intensity inhomogeneity in magnetic resonance imaging was developed for precise evaluation of human brain volume. To make the correction system publicly available, an open source automatic phantom image analysis program was also developed and validated among the MR machines with various magnetic field strength. The method will be examined for its effect in the diagnosis of dementia in future study.

Research Products

• [Presentation] シンポジウム5「脳ビッグデータを扱う」検診での集積と利活用 (2016)
  • Author(s): 山下典生
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2016-09-09
  • Invited
• [Presentation] 三次元ファントムによる超高磁場頭部MR画像の幾何歪み・信号むらの補正 (2015)
  • Author(s): 山下典生、佐々木真理、目時毅、樋口さとみ、上野育子、伊藤賢司、亀田浩之、齊藤紘一
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル
  • Year and Date: 2015-09-10
• [Patent(Industrial Property Rights)] 磁気共鳴イメージング装置用ファントム (2015)
  • Inventor(s): 山下典生、後藤俊介
  • Industrial Property Rights Holder: 学校法人岩手医科大学、有限会社ライトム
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-11-27
  • Overseas
• [Patent(Industrial Property Rights)] 磁気共鳴イメージング装置用ファントム (2014)
  • Inventor(s): 山下典生、後藤俊介
  • Industrial Property Rights Holder: 学校法人岩手医科大学、有限会社ライトム
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-239811
  • Filing Date: 2014-11-27