Development of a convenient assay for cell-mediated immunity to the influenza virus.
| Project/Area Number |
26870758
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
Epidemiology and preventive medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | インフルエンザ / ワクチン / 細胞性免疫 / 抗体 |
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| Outline of Final Research Achievements |
It is considered that immunological evaluation of the effect of influenza vaccines cannot be performed based on the antibody titer. In this study, using a new cell-mediated immunity measurement method, we investigated changes in the level of IFN-γ produced after vaccination in response to the vaccine antigen in 23 adults. Four subjects were infected with influenza A(H3N2) during the study period, and vaccination did not increase IFN-γ in these 4 subjects. It was suggested that the efficacy of influenza vaccines can be evaluated by measuring changes in the level of IFN-γ produced in response to influenza vaccine.
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Report
(4 results)
Research Products
(7 results)
