Effect of prenyl flavonoids on recovery from disuse muscle atrophy

• Project/Area Number: 26892020
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: The University of Tokushima
• Principal Investigator: MUKAI Rie 徳島大学, 大学院医歯薬学研究部, 助教 (90547978)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: フラボノイド / 筋萎縮 / 筋合成 / プレニルフラボノイド / 骨格筋 / ポリフェノール / タンパク質分解 / エストロゲン / ナリンゲニン

Outline of Final Research Achievements

We hypothesized that prenyl flavonoid improves the recovery of skeletal muscle from the disuse muscle atrophy. Right ankle of hind leg of mouse was fixed to induce disuse muscle atrophy. After that, prenyl flavonoid mixed diet or control diet was supplied to mice. To estimate the atrophy, weight of muscle was measured and ratio of atrophied muscle to control muscle was calculated. Muscle weight in supplementation group showed higher recovery than that in control diet group.

Research Products

• [Journal Article] Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability. (2015)
  • Author(s): Kyuichi Kawabata, Rie Mukai, Akari Ishisaka
  • Journal Title: Food & Function Volume: 印刷中 Issue: 5 Pages: 1399-1417
  • DOI: 10.1039/c4fo01178c
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] プレニルフラボノイドの生体利用性 プレニル化は体内滞留時間を延長させて、組織への蓄積を高める (2015)
  • Author(s): 向井理恵、寺尾純二
  • Journal Title: 化学と生物 Volume: 53 Pages: 71-73
  • NAID: 130005120431
• [Journal Article] プレニル化はフラボノイドの機能性を増強する (2015)
  • Author(s): 向井理恵、寺尾純二
  • Journal Title: バイオサイエンスとインダストリー Volume: 73
  • NAID: 40020476208
• [Journal Article] Prenylation modulates the bioavailability and bioaccumulation of dietary flavonoids (2014)
  • Author(s): J. Terao, R. Mukai
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 印刷中 Pages: 12-16
  • DOI: 10.1016/j.abb.2014.04.002
  • Peer Reviewed
• [Presentation] 8‐Prenylnaringenin enhances the recovery from disuse muscle atrophy of mice with cast immobilization (2015)
  • Author(s): Pei Yi Lin,Rie Mukai,Hitomi Horikawa, Junji Terao
  • Organizer: 12th Asian congress of Nutrition
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Anti-Oxidative Flavonoid suppresses disuse muscle atrophy in denervation mice. (2014)
  • Author(s): Rie Mukai, Naoko Matsui, Takeshi Nikawa,Junji Terao.
  • Organizer: XXVIIth International Conference on Polyphenols &8th Tannin Conference
  • Place of Presentation: 名古屋大学（愛知県名古屋市）
  • Year and Date: 2014-09-02 – 2014-09-06