| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The gastrointestinal stromal tumor (GIST) is related with activity of c-kit which is cell surface protein on GIST cells. The c-kit has been already used as a molecular target for the first line GIST therapy, and is also promising target molecule for targeted-adenovirus which is expected as an oncolytic virus therapy for next generation cancer therapy. In this study, two candidate motifs was identified for c-kit targeted-adenovirus by adenovirus-library screening system. In the future, c-kit targeted-adenovirus with these candidate motifs are expected as a for new oncolytic adenovirus therapy against GIST.
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