| Project/Area Number |
26893179
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 生体材料 / 歯科インプラント / 骨補填材 / 薬剤徐放性 / 骨増生 / 徐放担体 / 骨再生 |
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| Outline of Final Research Achievements |
It is well known that simvastatin is a cholesterol-lowering drug known to affect bone formation in vivo and its sustainable administration into localized areas is of particular interest in the dental field. Simvastatin-loaded poly(lactic-co-glycolic acid) (PLGA) formulations (PLGA microspheres and PLGA nanospheres) were compared to investigate whether a sustainable supply of simvastatin is effective for bone regeneration. PLGA microspheres successfully presented sustained release of simvastatin for one month, whereas simvastatin was continuously released from PLGA nanospheres within one week. In animal study, PLGA microspheres were superior to PLGA nanospheres on bone regeneration effect. Our data suggest that simvastatin-loaded PLGA microspheres can release simvastatin sustainably and induce bone formation more efficiently than PLGA nanospheres, thus promoting bone regeneration.
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