Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
The goal of this research is to investigate GABAergic transmission and try to detect its disfunction using autaptic culture of iPS cells made from the patients of the severe epilepsy, Dravet syndrome. But I can not get adequate response from the autaptic synapse on iPS cells. Then, in this study I used model mice of Dravet syndrome and discover that the GABAregic synaptic transmission of DS model mice was lowered but glutamatergic synaptic transmission was not change.
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