| Project/Area Number |
60440051
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IRIE Goro Hokkaido University School of Medicine, 医学部, 教授 (30001788)
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| Co-Investigator(Kenkyū-buntansha) |
ENOTO Takeaki Hokkaido University School of Engineering, 工学部, 助教授 (10001992)
ARIMOTO Takuro Hokkaido University School of Medicine, 医学部・付属病院, 講師 (50168027)
TSUJII Hirohiko Particle Radiotherapy Center, Tsukuba University
MIZOE Jun-etsu Hokkaido University School of Medicine
辻井 博彦 北海道大学, 医学部, 助教授 (50088853)
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| Project Period (FY) |
1985 – 1988
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥8,800,000 (Direct Cost: ¥8,800,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥7,800,000 (Direct Cost: ¥7,800,000)
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| Keywords | Inhomogeneous irradiation / Grid irradiation / Micro beam irradiation / スリットビーム / マイクロ篩照射 / 不均等線量分布 / 電子線照射 / 陽線スリット照射 / マイクロ節照射 |
|---|
| Research Abstract |
Effects of inhomogeneus irradiation using micro beam of 40 Mev proton and 45 MeV electron are investigated. Effects are measured by LD 50/30, skin reactions and local cure rate transplanted maligment tumors of mice and rats.
The results of the project have proved that: 1) Local recurrence of the tumor correlate strongly with minimum dose in the tumor inspite of its smallness in volume (fraction of a mm). 2) LD 50/30 is almost proportional to the total absorbed dose (Energy) given, inspite of the difference of unirradiated volume of up to 4 mm wide thickness.
The results disproved our working hypothesis, for our grief, that small unirradiated volume in a tumor would not affect the local cure rates but helps much protection of normal tissue.
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