| Project/Area Number |
60570256
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | Okayama University Medical School |
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Principal Investigator |
OGATA Masana Department of Public Health, Okayama University Medical School,, 医学部, 教授 (70032844)
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| Co-Investigator(Kenkyū-buntansha) |
OHSAKI Hirokazu Department of Industrial Science, School of Engineering, Okayama University, 工学部生産管理教室, 教授 (60032942)
TANAKA Yukiko Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 助手 (40163589)
MATSUDA Akira Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 助手 (60173837)
MEGURO Tadamichi Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 講師 (70093713)
KIRA Shouhei Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 講師 (50033212)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | biological monitoring / biological exposure indices / organic solvent / urinary metabolite |
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| Research Abstract |
Correlation between concentration of organic solvents in the air and concentration of their metabolites in the urine was examined. From above results, regression equation and their confidence intervals were calculated. The urinary metabolites corresponding TLV of organic solvents were estimated from the regression equation as follows; hippuric acid of toluene metabolite was 2.35 g/g creat., m-methylhyppuric acid of m-xylene metabolite was 2.05 g/g creat., total trichlorocompound of trichloroethylene metabolite was 334 mg/g creat., and phenol in phenol conjugates of phenol metabolites was 251 mg/g creat.
Concentration of organic solvent which can be discriminated exposure from non exposure, using hippuric acid or phenol conjugates was estimated to be 45 ppm of toluene or 2.4 ppm of phenol, respectively. Human biological exposure indices from Commission of European Communities and Documentation of Biological Exposure Indices(1986-1987) from ACGIH were translated into Japanese. And urinary metabolite concentration corresponding TLV of solvent concentration (benzene and hexane etc.) were estimated from references and validity was discussed. Concentration of urinary metabolites corrected with creatinine was decided to be av ilable for biological monitoring.
Total trichlorocompounds in the urine were studied for storage as follows;urine was frozen and kept -20゜C, or urine was spotted onto filterpaper and dried in a cold room, resulting in amounts of trichlorocompound suffered no markedly change for 7-10 days by both methods.
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