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Biological Monitoring of Industrial Solvents

Research Project

Project/Area Number 60570256
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionOkayama University Medical School

Principal Investigator

OGATA Masana  Department of Public Health, Okayama University Medical School,, 医学部, 教授 (70032844)

Co-Investigator(Kenkyū-buntansha) OHSAKI Hirokazu  Department of Industrial Science, School of Engineering, Okayama University, 工学部生産管理教室, 教授 (60032942)
TANAKA Yukiko  Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 助手 (40163589)
MATSUDA Akira  Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 助手 (60173837)
MEGURO Tadamichi  Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 講師 (70093713)
KIRA Shouhei  Department of Public Health, Okayama University Medical School,, 医学部公衆衛生学教室, 講師 (50033212)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsbiological monitoring / biological exposure indices / organic solvent / urinary metabolite
Research Abstract

Correlation between concentration of organic solvents in the air and concentration of their metabolites in the urine was examined. From above results, regression equation and their confidence intervals were calculated. The urinary metabolites corresponding TLV of organic solvents were estimated from the regression equation as follows; hippuric acid of toluene metabolite was 2.35 g/g creat., m-methylhyppuric acid of m-xylene metabolite was 2.05 g/g creat., total trichlorocompound of trichloroethylene metabolite was 334 mg/g creat., and phenol in phenol conjugates of phenol metabolites was 251 mg/g creat.
Concentration of organic solvent which can be discriminated exposure from non exposure, using hippuric acid or phenol conjugates was estimated to be 45 ppm of toluene or 2.4 ppm of phenol, respectively. Human biological exposure indices from Commission of European Communities and Documentation of Biological Exposure Indices(1986-1987) from ACGIH were translated into Japanese. And urinary metabolite concentration corresponding TLV of solvent concentration (benzene and hexane etc.) were estimated from references and validity was discussed. Concentration of urinary metabolites corrected with creatinine was decided to be av ilable for biological monitoring.
Total trichlorocompounds in the urine were studied for storage as follows;urine was frozen and kept -20゜C, or urine was spotted onto filterpaper and dried in a cold room, resulting in amounts of trichlorocompound suffered no markedly change for 7-10 days by both methods.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 緒方正名,田口豊郁: International Archives of Occupational and Environmental Health. 58(2). 121-129 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 緒方正名,山崎吉郎,河合俊夫: International Archives of Occupational and Environmental Health. 58(3). 197-202 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 緒方正名,田口豊郁: 産業医学. 28. 120-123 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 緒方正名,嶋田義弘,田口豊郁: Industrial Health. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 緒方正名,田口豊郁: International Archives of Occupational and Environmental Health. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 緒方正名,武田和久,訳: "工業化学物質のヒトにおける生物学的モニタリング" 同文書院, 107 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 緒方正名,訳: "生物学的暴露指数勧告理由書" 同文書院, (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata Masana, Taguchi Toyohiro: "Quantitative analysis of urinary glycine conjugates by high performance liquid chromatography: excretion of hippuric acid and methylhippuric acids in the urine of subjects exposed to vapours of toluene and xylene." International Archives Occupational Environmental and Health. 58(2). 121-129 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata Masana, Yamazaki Yoshio, Kawai Toshio: "Significance of urinary phenyl sulfate and phenyl glucuronidase of exposure to phenol." International Archives Occupational Environmental and Health. 58(3). 197-202 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata Masana, Taguchi Toyohiro,: "Quantitative determination of urinary hippuric acid and o-,m- and p- methylhippuric acids by high performance liquid chromatography." Japanese Journal of Industrial Health. 28(2). 120-123 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata Masana, Shimada Yoshihiro, Taguchi Toyohiro: "Microdetermination and excretion of trichlorocompounds in the urine of workers exposed to trichloroethylene vapour." Industrial Health. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata Masana, Taguchi Toyohiro: "Quantitation of urinary metabolites of toluene, xylene, styrene and ethylbenzene and those of benzene and phenol by automated high performance liquid chromatography." International Archives Occupational Environmental and Health. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata Masana, Takeda Kazuhisa: Dobunshoin, Tokyo. Japanese translation of L.Alessio, A.Berlin,R.Roi, M.Boni:Human biological monitoring of industrial chemicals series. Commission of the European Communities, 107 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ogata Masana: Dobunshoin, Tokyo. Japanese translation of Documentationof biological exposure indices(1986-1987), (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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