| Project/Area Number |
60570752
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Ehime University |
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Principal Investigator |
FUJITA Kiyoshi (1986) Ehime University, Assistant, 国立大学(その他), 助手 (10145089)
越知 憲治 (1985) 愛媛大学, 医学部, 助教授
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| Co-Investigator(Kenkyū-buntansha) |
AKIRA Wakatsuki Ehime University, Assistant, 医学部, 助手 (80116996)
HIDENOBU Iwata Ehime University, Associated Professor, 医学部附属病院, 講師 (40108379)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | T-antigen / 抗T抗体 |
|---|
| Research Abstract |
TUR specimens of non-invasive transitional-cell carcinomas were examined for their expression of Thomsen-Friedenreich (T) antigen by indirect immunofluorescence staining using rabbit IgG antibody which was raised with desialated glycophorin. Nine(45%) out of 20 tumors of low grade (Grade I and II), and 5(56%) of 9 tumors of high grade (III) were diffusely stained with anti-T(T-positive),whereas T-antigen in normal tissue was cryptic and stained only after neuraminidase treatment (cryptic T-positive). Of the T-negative tumors, 9(45%) of the low grade but only one of the high grade tumors, were stained positively for the cryptic T-antigen. The rest of the tumors were devoid of the cryptic T-antigen. Eighty percent of both Tumors expressing T-antigen and those lacking the cryptic T-antigen recurred within two years. Recurrence was not influenced by initial histological grade.
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