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Preventive measurement for vaccine brak of Marek's Disease, Divelopment of the vaccine in particular

Research Project

Project/Area Number 60860031
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionFaculty of Veterinary Medicine, Hokkaido University

Principal Investigator

MIKAMI Takeshi  Faculty of veterinary Medicine, Hokkaido University, 獣医学部, 助教授 (20091506)

Co-Investigator(Kenkyū-buntansha) NAIKI Masaharu  Faculty of Veterinary Medicine, Hokkaido University, 獣医学部, 助教授 (10020752)
MIATSUBA Haruo  Faculty of Applied Biological Science, Hiroshima-University, 生物生産学部, 助教授 (80116863)
ITAKURA Chitoshi  Faculty of Veterinary Medicine, Hokkaido University, 獣医学部, 教授 (30021695)
HIRAI Kanji  Tokai University School of Medicine, 医学部, 講師 (00100991)
KATO Shiro  Research Institute for Microbial Diseases, Osaka University, 微生物病研究所, 教授 (90029752)
森口 良三  北海道大学, 獣医学部, 助手 (30101299)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥25,200,000 (Direct Cost: ¥25,200,000)
Fiscal Year 1987: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1986: ¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 1985: ¥8,500,000 (Direct Cost: ¥8,500,000)
KeywordsMarek's disease / vaccine break / vaccine / Marek's disease virus / herpesvirus of turkeys / mon-oncogenic virus / マレック病リンパ腫 / ワクチンブレイク / 鶏貧血性因子 / 免疫抑制 / 羽髄病変 / マレック病ヘルペスウイルス / 腫瘍抗原
Research Abstract

The final aim of the present study is to develop Marek's disease (MD) vaccine which prevents the vaccine break induced by MD. The following results were obtained at Present.
1) The group of MD virus (MDV) and herpesvirus of turkey (HVT) is serologically devided into 3 groups. Many hybridoma secreting monoclonal antibody specific to each group or strain used as inoculum were developed. By using these antibodies, it became possible to identify the serotype of the viruses isolated from th field. Further, several monoclonal antibodies specific to MD lymphoma cells were developed for identification of MD tumor cells.
2) The incidence of MD and effect of HVT vaccine in Japanese quails were investigated. Pathological lesions specific to MD were observed in many quails. There was a positive correlation between the incidence of lymphomatous changes and the prosence of MMV-specific antigen in feather follicle, and there was a negative correlation between the incidence of lympomatous changes and the presence of antibody against HVT on a flock basis. the MDV isolated from the quails belongs to serotype 1 and these were highly pathogenic to chickens. the similar virus was also isolated from chikens in field.
3) It is essential to isolate the new type of non-oncogenic MDV for development of the MD vaccine to control the vaccine break of MD. Attempts were made to isolate the virus from 13 chickens and 10 pheasant. Thirteen viruses isolated from cell of th chickens, and all of the viruses belong to serotype 2 as identified by the monoclonal antibody.By using these viruses, it is feasible to develop the more effective vaccine fought against vaccine break of MD in the near future.

Report

(3 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • 1985 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] Mikami,T.: Avian Diseases. 29. 250-255 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Higashiyama,T.: Poultry Science. 64. 877-881 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hirai,K.: International Symposim on Marek's Disease. 30-50 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Mikami,T.: International Symposium on Marek's Disease. 214-235 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yasuda,M.: Japanese Journal of Veterinary Science. 47. 835-839 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Moriguchi, R.: "Feather pulp leasions in chickens with naturally occurring Marek's disease lymphoma" Avian Diseases. 31. 156-168 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kobayahsi,S.: "Some epizootiological and pathological observations on Marek's disease in Japanese quaild" Preventive Veterinary Medicine. 5. 141-150 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ohashi,K.: "Suppression of NK activity of spleen cells by chicken fetal antigen present on Marek's disease lymphoblastoid cell line cells" International Journal of Cancer. 40. 378-382 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nakajima, K.: "Analysis of Marekhs disease virus serotype 1-specific phosphorylated Polypeptides in virus infected cells and Marek's disease lymphoblastioid cells" Journal of General Virology. 68. 1379-1389 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kanamori,A.: "Methylation of Marek's disease virus DNA in chicken T-lymnphoblastiod cell lines" Journal of General Virology. 68. 1485-1490 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kirisawa,R.: Archives of Virology. 89. 29-43 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yachida,S.: Archives of Virology. 91. 183-192 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hayashi,Y.: Japanese Journal of Veterinary Science. 48. 915-924 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yu,D.-H.: Japanese Journal of Veterinary Science. 48. 1141-1146 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Higashihara,T.: Journal of the National Cancer Institute. 76. 1085-1094 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Naito,M.: Avian Pathology. 15. 503-510 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hirose,H.: Japanese Journal of Veterinary Science. 48. 1263-1266 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yamada,M.: Archives of Virology. 90. 183-196 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yamada,M.: Microbiology and Immunology. 30. 1259-1270 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Mukuria,J.C.: Immunology Letters. 12. 165-169 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Suzuki,E.: Japanese Journal of Veterinary Research. 35. 11-20 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Mukuria,C.J.: Journal of Biochemistry. 100. 469-475 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nakajima,K.: Journal of Virology. 59. 154-158 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hirai,K.: Archives of Virology. 89. 113-130 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hirai,K.: Virology. 152. 256-261 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Maotani,K.: Journal of Virology. 58. 657-660 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 福地邦彦: 蛋白質.核酸.酵素. 31. 949-969 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Ikuta,K.: International Journal of Cancer.

    • Related Report
      1986 Annual Research Report
  • [Publications] Nakajima,K.: Journal of General Virology.

    • Related Report
      1986 Annual Research Report
  • [Publications] Kanamori,A.: Journal of General virology.

    • Related Report
      1986 Annual Research Report
  • [Publications] Kanamori,A.: Biken Journal.

    • Related Report
      1986 Annual Research Report
  • [Publications] Igarashi,T.: Virology.

    • Related Report
      1986 Annual Research Report
  • [Publications] Moriguchi,R.: Avian Diseases.

    • Related Report
      1986 Annual Research Report
  • [Publications] Matsuda,H.: Japanese Journal of Veterinary Science. 48. 1021-1023 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Int.J.Cancer. 35-2. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] J.gen.Virol.66-6. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] Jpn J.Vet.Sci. 47-5. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] Avian Dis.29-2. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] Int.Symp.Marek's Dis.PP214 (1985)

    • Related Report
      1985 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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