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制癌剤の高分子化と油性化による腫瘍親和性の増強に関する基礎的研究

Research Project

Project/Area Number 61010060
Research Category

Grant-in-Aid for Cancer Research

Allocation TypeSingle-year Grants
Research InstitutionKumamoto University

Principal Investigator

前田 浩  熊本大, 医学部, 教授 (90004613)

Co-Investigator(Kenkyū-buntansha) 今野 俊光  熊本大学, 医学部附属病院, 講師 (60117348)
稲田 祐二  東京工業大学, 理学部, 教授 (40016035)
桑野 信彦  大分医科大学, 教授 (80037431)
橋田 充  京都大学, 薬学部, 助教授 (20135594)
馬場 恒男  九州大学, 生医研, 教授 (70037323)
Project Period (FY) 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 1986: ¥12,700,000 (Direct Cost: ¥12,700,000)
Keywords高分子制癌剤 / EPR効果 / 油性制癌剤 / スマンクス / ピラン結合アドリアシン / デキストラン-マイトマイシン / 肝転移の予防 / リンパ節転移
Research Abstract

当班の研究目的の一つである高分子化制癌剤が固型腫瘍に対し、一段と優れた集積性と制癌作用を発揮することを、血清蛋白質,スマンクス,ピラン結合-アドリアシン,および多糖結合型マイトマイシンCなどによって明瞭に実証した。そのうちでも、分子量が10万以上になると腫瘍の血管外への漏出が遅くなることもはっきりした。また、高分子制癌剤は、直径2〜3mm以下のものよりも、数mmの大きさになったものの方がより有効であることがわかった。次に、油剤化であるが、実験モデルで、(1)in vitroの耐性克服の実証,(2)腸がんの手術時の門脈内投与による肝転移の激減,(3)腫瘍動脈内注入によるリンパ節転移の治療など明るい見通しがついた。また、リピオドール以外に、中鎖脂肪酸エステルが優れた動注用のドラッグキャリアーであることを見出した。

Report

(1 results)
  • 1986 Annual Research Report
  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] 前田浩: 細胞工学. 5. 442-451 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 前田浩: 代謝. 23. 249-258 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 湯本泰弘: 消化器外科. 4. 138-147 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 平山智子: Jap.J.Antibiotics. 39. 815-822 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 酒本貞昭: 西日本泌尿器科. 48. 9-17 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 神野健二: 肝臓. 27. 471-479 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 黒岩俊郎: 病態生理. 5. 982-984 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 桑野信彦: 西日本泌尿器科. 48. 1-7 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高橋俊雄: 新薬事報. 1380. 13-14 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高橋俊雄: 日本外科学会雑誌. 87. 1000-1004 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 今野俊光: 日本癌治療学会誌. 21. 182-184 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 今野俊光: 癌と化学療法. 13. 1448-1455 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 牧祥二郎: 癌と化学療法. 13. 1603-1610 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 松村保広: 癌と化学療法. 14. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 馬場恒男: 癌と化学療法. 14. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 黒岩俊郎: 癌と化学療法. 14. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Oda T.: Proc.Soc.Exp.Biol.Med.181. 9-17 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Matsumura Y.: Cancer Res.46. 6387-6392 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Baba T.: Jpn.J.Cancer Res.77. 432-435 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Inada Y.: Trends in Biotechnol. 4. 68-73 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yoshimoto T.: Enzyme. 36. 261-265 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yoshimoto T.: Jpn.J.Cancer Res.77. 1264-1270 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Akiyama S.: J.Nat.Cancer Inst.76. 839-844 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yamaguchi T.: J.Nat.Cancer Inst.76. 947-953 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nakagawa M.: Cancer Res.46. 4453-4457 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Takahashi T.: CRC Critical Reviews.2. 245-274 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hirano T.: Makromolekulare Chemie.187. 2815-2824 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Matsumoto S.: Cancer Res.46. 4463-4468 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Maeda H.: Cancer Res.47. 563-566 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yamasaki K.: Cancer Res. 47. 852-855 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Ohtsuka N.: Cancer. 59. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yanagita T.: Cancer. 59. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Takahashi T.: Cancer. 59. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Iwai K.: Anticancer Res.7. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Shiraishi N.: Cancer Res.(1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Akiyama S.: Biochem.Pharmacol.(1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Shiraishi,N.: Cancer Lett.30. 251-259 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Oda T.: Cancer Res.47. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 橋田充: "ドラッグデリバリーシステム:新しい投与剤形を中心とした製剤学。" 南江堂, 25 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高倉喜信: "ドラッグデリバリーシステム" シーエムシー, 4 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 前田浩: "癌化学療法の進歩" メジカルビュー社, 6 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 前田浩: "新しい癌治療法の開発ー癌へのターゲッティングをめざして" サイエンスフォーラム, (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 前田浩 翻訳: "Protein Tailoring for Food and Medical Uses.(食品と医薬のための蛋白質の改変)" 学会出版センター, (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Maeda H.: "Protein-Tailoring for Food and Medical Uses and Reagents." Marcel Dekker Inc., 29 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Kuwano M.: "Cancer Drug Resistance" Alan R.Liss,Inc., 10 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Kuwano M.: "Cancer Chemotherapy:Challenges for the Future." Excerpta Medica, 8 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Konno T.: "Cancer Chemotherapy:Challenges for the Future." Excerpta Medica, 8 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Konno T.;H.Maeda: "Neoplasms of the Liver" Springer-Verlag, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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