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Experimental studies on toxicity of and requirement for the trace elements: its modification by the environmental factors.

Research Project

Project/Area Number 61480162
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionUniversity of Tokyo

Principal Investigator

SUZUKI Tsuguyoshi  Professor,Dept.Human Ecology,Sch.Health Sciences,Fac of Medicine,U of Tokyo, 医学部, 教授 (80009894)

Co-Investigator(Kenkyū-buntansha) HONGO Tetsurou  Instructor,Dept.Human Ecology,Sch Health Sciences,Fac Medicine,U of Tokyo, 医学部, 助手 (90199563)
KASHIWAZAKI Hiroshi  Lecturer,Dept.Human Ecology,Sch.Health Sciences,Fac Medicine,U of Tokyo, 医学部, 講師 (60004735)
門司 和彦  東京大学, 医学部, 助手 (80166321)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsToxicity of trace elements / Requirement of trace elements / Environmental factors / Selenium / Mice / Modification of toxicity by environmental factors / セレン化合物 / 投与経路 / 血中濃度 / 環境温 / 亜鉛欠乏 / グルタチオンリダクターゼ / 微量元素の必須性 / 環境温度 / 生体影響の指標 / 個体群飼育
Research Abstract

The purpose of this study is to provide basic and experimental information about modification of toxicity and/or fequirement of trace metals in human populations by their various living environments. Specifically, we examined the influence of ambient temperature (Ta) on toxicity of a trace element, selenium, using mice as the experimental animal.
Major findings in this study are as following;
1. We found hypothermia as a transient and Ta-dependent effects of sublethal dose of sodium selenite (SS). The acute lethality of SS was raised at higher Ta, where hypothermia did not occur.
2. The Ta in the short period of post-injection seemed to have a critical role in determining the delayed toxic effects of a single SS administration. This modification of toxicity by Ta was not cancelled by a prior acclimatization of mice to Ta. Thus Ta is significant in evaluating the toxicity of SS.
3. Another acute effect of SS, hyperphagia, was also Ta-dependent. On the other hand, other two biological effects of SS, i.e.; induction of metallothionein, and attenuation of Hg toxicity, did not appear to relate with Ta and/or the hypothermic event.
4. Mechanism of SS hypothermia was not elucidated. Since other chemical forms of selenium compounds also induced hypothermia, Se might be the responsible agent; however, reselenomethionine did not cause hypothermia. Since our preliminary study showed that several of other inorganic salts induced hypothermia, we are now investigating the specificity of this effect.
5. Our future project may include 1) modification of requirement for Se and Zn by Ta; and 2) the effects of hypoxia on the toxicity and/or requirement for Se.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] C.Watanabe;T.Suzuki: Toxicol.Appl.Pharmacol.86. 372-379 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Ohba;T.Suzuki;C.Watanabe;S.Himeno: Toxicol.Lett.39. 275-281 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] C.Watanabe;T.Ohba;H.Nakahara;T.Suzuki: Toxicology. 51. 167-176 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] N.Iwai;C.Watanabe;T.Suzuki;K.Suzuki;C.Tohyama: Arch.Tox.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] C. Watanabe; T. Suzuki: "Sodium selenite-induced hypothermia in mice: indirect evidence for a neural effect." Toxicol. Appl. Pharmacol.86. 372-379 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T. Ohba; T. Suzuki; C. Watanabe; S. Himeno.: "Transient hyperphagia after sodium selenite injection in mice." Toxicol. Lett.39. 275-281 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] N. Iwai; C. Watanabe; T. Suzuki; K. Suzuki; C. Tohyama: "Metallothionein induction by sodium selenite at two ambient temperatures in mice." Arch. Toxicol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] C. Watanabe; T. Ohba; H. Nakahara; T. Suzuki: "Modification of lethal, hypothermic and hyperphagic effects of sodium selenite by reduced glutathione in mice." Toxicology. 51. 167-176 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] C.Watanabe;T.Suzuki: Toxicol.Appl.Pharmacol.86. 372-379 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Ohba;T.Suzuki;C.Watanabe;S.Himeno: Toxicol.Lett.39. 275-281 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] C.Watanabe;T.Ohba;H.Nakahara;T.Suzuki: Toxicology. 51. 167-176 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] N.Iwai;C.Watanabe;T.Suzuki;K.Suzuki;C.Tohyama: Arch.Tox.

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Ohba: Toxicology Letters. 39. 275-281 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] C.Watanabe: Toxicology.

    • Related Report
      1987 Annual Research Report
  • [Publications] C.Watanabe: Toxicology and Applied Pharmacology. 86. 372-379 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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