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Structure and function of the external urethral sphincter (EUS)

Research Project

Project/Area Number 61480337
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionHokkaido University

Principal Investigator

KOYANAGI Tomohiko  Hokkaido University School of Medicine, 医学部, 教授 (80001923)

Co-Investigator(Kenkyū-buntansha) MORITA Hajime Hokkaido U  北海道大学, 医学部, 助手 (60200424)
谷口 光太郎  北海道大学, 医学部, 助手 (20171845)
後藤 敏明  北海道大学, 医学部附属病院, 助手 (50153763)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥5,400,000 (Direct Cost: ¥5,400,000)
Keywordsexternal uretheral sphincter / autonomic adrenergic nerves / Detrusor-Sphincter-Dyssynergia / radical TURP Urodynamic / ウロダイナミック / α-交換刺激 / 外尿道括約筋(EUS) / 神経因性膀胱 / α-activation / radical TURP / Detrusor sphincter dyssynergia(DSD)
Research Abstract

1) On electron microscopic study of human male urethra there was a rich supply of autonomic adrenergic nerves in the interstitium of peripheral lobe of the prostatic urethra. These adrenergic fibers descended further more as autonomic efferents to the EUS, Wherein they formed so called surface junctions, suggesting adrenergic involvement in the function of human EUS.
2) Ultrastructurally there seem to be three types of striated muscle - two types of red muscle and one type of white muscle.
3) In neurogenic voiding dysfunction the activity of EUS as assessed by its electromyography was correlated ot the severity of vesicoureteral feflux and associated renal scarring.
4) Alpha-adrenergic activation of EUS in neurogenic bladder seems to be partially responsible for the genesis of detrusor-sphincter-dyssynergia(DSD), a leading cause of voiding dysfunction among these subjects.
5) Radical TURP relieves voiding dysfunction by relieving DSD through ist effects equivalent to intramural surgical sympathetectomy.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 熊谷章: 日本泌尿器科学会雑誌. 77. 930-937 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 森田肇: 北海道医学雑誌. 62. 82-95 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Koyanagi, T. et al: Journal of Urology. 137. 72-76 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kumagai, A. et al: Urological Research. 15. 39-43 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Koyanagi, T. et al: European Urology. 14. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kumagai,A.: "Ultrastructrual study of human external urethral sphincter." The Japanese Journal of Urology. 77. 930-937 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Morita,H.: "Radical transurethral resection of prostate for spinal cord bladder: Its therapeutic effects and urodynamic evaluations." The Hokkaido Journal of Medical Science. 62. 82-95 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Koyanagi.T. et al: "Radical transurethral resection of the prostate in male paraplegics revisited; further clinical experience and urodynamic considerations for its effectiveness." Journal of Urology. 137. 76-76 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kumagai,A. et al: "The innervation of the external urethral sphincter; An ultrastractural study in male human subjects." Urological Research. 15. 39-43 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Koyanagi,T. et al: "Neurogenic urethra; clinical relevance of isolated neuropathic dysfunction of the urethra, and the deneration supersensitivity of the urethra revisited." European Urology. 14. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Koyanagi,T.et al: Journal of Urology. 131. 1122-1126 (1984)

    • Related Report
      1986 Annual Research Report
  • [Publications] Koyanagi,T.et al: Journal of Urology. 137. 72-76 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 森田肇: 北海道医学雑誌. 62. 82-95 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高松恒夫: 日本泌尿器科学会雑誌. 76. 687-694 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] 熊谷章: 日本泌尿器科学会雑誌. 77. 930-937 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Kumagai,A.et al: Urological Research. 15. 39-43 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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