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Experimental study on high-dose chemotherapy with autologous bone marrow transplantation against solid tumor

Research Project

Project/Area Number 61570370
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

MIZUSHIMA Yutaka  lst Department of Internal Medicine, Toyama Medical and Pharmaceutical Universit, 附属病院, 助手 (20174021)

Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsHigh-dose chemotherapy / 大量化学療法 / 自家骨髄移植 / 骨髄移植 / 固型癌 / 抗癌の骨髄抑制
Research Abstract

In order to know which anticancer drugs are more appropriate for high-dose chemotherapy (HC) with autologous bone marrow transplantation (BMT) in cancer therapy, we tested six drugs (ACNU, ADR, CY, MMC, VDS, VP-16) in sprague-Dawley (SD) rats. Two or three varying doses of each drug were given iv on day O, followed by syngeneic BM cells (5x10^7,iv) on day 2, and animals were observed for over 60 days. ADR caused a high rate of peripheral neuropathy rather than myelosuppression death, so ADR was considered to be inappropriate for HC-BMT. Among other five drugs, a beneficial effect of BMT was observed only with CY (300-400 mg/kg) and ACNU (40 mg/kg). In order to increase the beneficial effect of BMT, administration ways of CY and ACNU were designed, and better survival curves were obtained in the following administration groups; 1) (CY 200 mg/kg, days 0 & 1) BMT> (CY 400 mg/kg, day 0) BMT, (ACNU 20 mg/kg, day 0 & 1) BMT> (ACNU 40 mg/kg, day 0) BMT, 2) (CY 200 mg/kg ACNU 20 mg/kg, day 0) BMT>(CY 400 mg/kg or ACNU 40 mg/kg, day 0) BMT, 3) (CY 200 mg/kg, day 0) (acanau 20 mg/kg, day 1) BMT> (ACNU 20 mg/kg, day 0 ) (CY 200 mg/kg, day 1) BMT.
Among six anticancer drugs tested in this study, CY and ACNU were suggested to be more appropriate drugs for HC-BMT, but devices for reducing drug toxicity are considered to be necessary for increasing the beneficial effect of BMT.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report

URL: 

Published: 1987-03-31   Modified: 2016-04-21  

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