| Project/Area Number |
61870021
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | University of Tokyo |
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Principal Investigator |
TOMONAGA Masanori Faculty of Medicine, University of Tokyo, 医学部, 教授 (10072977)
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| Co-Investigator(Kenkyū-buntansha) |
勝沼 英宇 東京医大, 老年科, 教授
萬年 徹 東京大学, 医学部, 教授 (10010208)
MURAYAMA Shigeo Faculty of Medicine, University of Tokyo, 医学部, 助手 (50183653)
IKEDA Kazuhiko Faculty of Medicine, University of Tokyo, 医学部, 助手 (30124663)
MANNEN Tohru Faculty of Medicine, University of Tokyo
TOMONAGA Masanori Faculty of Medicine, University of Tokyo (30078307)
KATUNUMA Eiu Tokyo Medical College
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥27,000,000 (Direct Cost: ¥27,000,000)
Fiscal Year 1988: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1987: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1986: ¥21,000,000 (Direct Cost: ¥21,000,000)
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| Keywords | Image analysis / Morphometry / Nerve cell / Peripheral nerve / 筋肉 / 画像解析 / 老化 / プルキエ細胞 / ゴルジ標本 / 自動画像計測 / 有髄線維径 / 有髄線維密度 |
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| Research Abstract |
When we study the changes of human nervous system, especially in the field of neuropathology, we use qualitative method or quantitative method. For the latter, we have used mainly namual one, such as DIGIPLAN as the best. However, this method was very time-consumed when the number of the material was large. On the other hand, we have had also automatic morphometrical apparatus, such as QUANTIMET, however, which was not enough to differentiate the histological structure, because the capacity was restricted in discrimination of only the density. We tried to develope the quantitative system to differentiate and measure the structure by the color tone in the stained histological specimens. For this purpose we used dimentional image processor, nexus 6400, which was used in landsat technology. We developed the programs to measure the following structure : the number and size of nerve cells, arborization of dendrites, number of glia, the number, diameter and area of peripheral nerve and muscle.
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