| Project/Area Number |
62045042
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| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
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| Allocation Type | Single-year Grants |
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| Section | University-to-University Cooperative Research |
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| Research Institution | Fukuoka University |
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Principal Investigator |
HAMASAKI Naotaka Fukuoka University School of Medicine, Fukuoka, Japan, 医学部, 教授 (00091265)
浜崎 直孝 (1989) 福岡大, 医, 教授
濱崎 直考 (1987) 福岡大, 医, 助教授
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| Co-Investigator(Kenkyū-buntansha) |
RICHARD J.La 米国イリノイ大学, 医学部, 助教授
OMACHI Akira University of Illinois at Chicago, Health Sciences Center, U.S.A., 医学部, 教授
OKUBO Kenshi Fukuoka University School of Medicine, Fukuoka, Japan, 医学部, 助手 (40194097)
LABOTKA Lichard J. University of Illinois at Chicago, Health Sciences Center, U.S.A.
RICHARD J La イリノイ大学, 医学部, 助教授
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1989: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1988: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1987: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Phosphoenolpyruvate transport across the cell membrane / Red Cell Membrane / Band 3 / Phosphate transport system / Histidine residue / Mediated transport / Structure of transmembrane protein |
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| Research Abstract |
This project is concerned with the transport mechanisms of phosphoenolpyruvate across the red cell membrane. Results of this project are summarized as follows: 1. Transport of phosphoenolpyruvate is mediated by Band 3 protein of red cell membrane as well as the transports of chloride and phosphate. 2. The 60th-lysine residue from the COOH-terminal end of Band 3 constitutes at least a part of the active center of the transport system. 3. In addition to the lysine residue, a histidine residue within Band 3 participates in the transport system. The histidine is located at the intracellular surface of the cell membrane and allosterically interacts with the transfer site. 4. Phosphoenolpyruvate transports across not only the red cell membrane but also the cell membranes of kidney and liver.
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