| Project/Area Number |
62570274
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Legal medicine
|
|---|
| Research Institution | Hyogo College of Medicine |
|---|
Principal Investigator |
HISHIDA Shigeru Department of Legal Medicine, Hyogo College of Medicine, 医学部, 教授 (10068463)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Tadaaki Department of Legal Medicine, Hyogo College of Medicine, 医学部, 助手 (80155209)
|
|---|
| Project Period (FY) |
1987 – 1988
|
| Project Status |
Completed (Fiscal Year 1988)
|
| Budget Amount *help |
¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
|
|---|
| Keywords | alcohol preference / rat's hereditary background / Skinner's box / 近親交配 / 遺伝的背景 / Wister / Long-Evans / Lewis / Fischer / 近系交配 / Alcohol / diet / アルコール弁別自発摂取 / パーソナルコンピューター / アルコール摂取率 |
|---|
| Research Abstract |
A basic experiment to investigate whether a rat's hereditary background affects preference for alcohol was preformed using an apparatus allowing rats to select alcohol voluntarily.
An apparatus was employed to evaluate rat's preference for alcohol using a Skinner box that was improved to a one-lever, two-liquid delevery system. That is, it was so designed that when a rat pushes down on the lever in the surface of a wall in the Skinner's box, an alterating water or 10% alcohol solution will come out of the nozzle located in the center of the wall.
A personal computer manufactured by NEC(9800UM) was connected to this apparatus allowing easy operation and control to be performed, and the data was processed by intergrated software.
The Wister strain, Long-Evans strain, Lewis strain, and the Fischer strain of rats were selected to investigate for differences in alcohol preference. This preference for alcohol by strain of rat was investigated and frequencies obtained of rats apperaing to show a high preference for alcohol. These were then classified by strain. Results: 1. The frequency of appearance of preference for alcohol was higher in Lewis and Wister strain rats than the other strains. The long-evans strain showed the lowest frequency of alcohol preference. 2. Male and female rats with the highest preference for alcohol in the same strain were selected. These were made to inbreed and the resultant young were found to have higher rates of preference for alcohol than their parents. 3. It was also found that a rat's preference for alcohol will rise when they are chronically fed an alcohol diet(a diet consisting of liquid feed containing alcohol).
|
