| Project/Area Number |
62870043
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
AKISADA Masayoshi Univ. of Tsukuba, Inst. of Clin. Med., Prof., 臨床医学系放射線, 教授 (90110494)
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| Co-Investigator(Kenkyū-buntansha) |
ANNO Izumi Univ. of Tsukuba, Inst. of Clin. Med., Assist.Prof., 臨床医学系, 講師 (50138707)
SUGISHITA Yasuro Univ. of Tsukuba, Inst. of Clin. Med., Associate Prof., 臨床医学系, 助教授 (90010131)
HYODO Kazuyuki 高エネルギー研, 放射光実験施設, 助手 (60201729)
ANDOH Masami 高エネルギー研, 放射光実験施設, 教授 (30013501)
HASEGAWA Shin 電気通信大学, 電子工学, 教授 (60017308)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥19,000,000 (Direct Cost: ¥19,000,000)
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| Keywords | Synchrotron radiation / Coronary angiography / K-edge / Energy subtraction / Angio-cardiography |
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| Research Abstract |
Ischemic heart disease which leads to the cause of sudden death, is the most serious disease in the industrial countries. In Japan, the incidence of heart disease has been ranked next to that of malignant tumor since 1985. The number of death due to ischemic heart disease based on arteriosclerosis of coronary arteries in 1987, have increased 5 times more than that in 1950. The selective coronary angiography is the final diagnostic modality for the ischemic heart disease. But this modality is invasive and costly because a special catheter must be directly inserted into coronary arteries using a special angiographic system, and have hospitalization. Therefore new and safer diagnostic method for ischemic heart disease has been required year by year.
Only k-edge energy subtraction angiography with synchrotron radiation can reveal the coronary artery via the intravenous injection of contrast material. And two dimensional image acquisition system which can demonstrates the images as a conventional cine-angiography, is being constructed at Photon Factory in Tsukuba. This system consists of five elements. 1) Sufficient X-ray flux(Insertion device; Wiggler). 2)High speed energy switching(Above and below K-edge). 3)Beam expansion(Asymmetric reflection on Silicon crystal). 4)High speed image acquisition TV system 5)Image processing.
The experiments with this prototype angiographic system showed that coronary artery could be demonstrated dearly in the animal such as dog. The elements of 3) and 4) were nearly finished. But for the human studies, the most important problems of this system is an insufficient X-ray flux and a high speed energy switching. Insertion device must be developed for a sufficient X-ray flux. And new methods of energy switching might be suitable because mechanical energy switching using the vibration of large silicon crystal might have dynamic problem such as strains of crystal by moment. Further studies will be needed especially in 1)and 2) elements.
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