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Studies on PGI2 regulatory factor, EDCF and EDRF

Research Project

Project/Area Number 63440036
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KAWAI Chuichi  3rd Div, dept of Int, 医学部, 教授 (70025659)

Co-Investigator(Kenkyū-buntansha) YUI Yoshiki  same above, 医学部, 助手 (20158330)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥28,300,000 (Direct Cost: ¥28,300,000)
Fiscal Year 1989: ¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 1988: ¥18,000,000 (Direct Cost: ¥18,000,000)
KeywordsEDR / EDRF / Thrombosis / AMI / NO / プロスタサイクリン半減期 / 急性心筋梗塞 / Apo AI / 粥状動脈硬化 / 心筋硬塞 / 血栓 / HDL
Research Abstract

1. Serum prostacyclin stabilizing factor was found to be identical to apolipoprotein AI, an apolipoprotein of HDL. This factor seems to have important relation to the coronary thrombus formation.
2. A new relaxing factor from bovine retractor penis muscle was found to be RSNO and NO.
3. Serum lipoprotein was found to inhibit EDR.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Ryliichi Hattorietal: "Reocclusion of the infarated vessel during acute interventions in MI" Jpn.Cie.J.52. 709-714 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshiki Yui et al: "Serum prostacyclin stabilizing factor is edentical to Apo A-I" J.Clin.Invest.82. 803-807 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshiki Yui et al: "mechanism for the generation of octiue sncaoth muscle in hibitory factor from bovine retroctor penis musle" B.B.R.C.164. 544-549 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mamoru Takahashi et al: "Lipoproteins are inhibitons of EDR" Amer.J.Physial.258. 1-8 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeshi Aoyama et al: "Prostacyclin haef-life regulated luy HDL is decriased in AMI and UAP" Cinculation(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ryuichi Hattori et al.: "Reocclusion of the infarcted vessel during acute interventions in MI." Jpn. C. J. 52. 709-714 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshiuki Yui et al.: "serum prostacyclin stabilizing factor is identical to Apo AI." J. Clin. Invest. 82, 803-807, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshiki Yui et al.: "Mechanism for the generation of active smooth muscle inhibitory factor from bovine retractor penis muscle" B.B.R.C. 164, 544-549, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mamoru Takahashi et al.: "Lipoproteins are inhibitors of EDR." Amer. J. Physiol. 258, 1-8, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeshi Aoyama et al.: "Prostacyclin half-life regulated by HDL is decreased in AMI and UAP" Circulation.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takahashi Mamoru: "dipoproteins are inhibitors of endothelium dependent relaxation of the rablit aorta" American Journal of Physiology.

    • Related Report
      1989 Annual Research Report
  • [Publications] Yui Yoshiki: "mechanism for the generation of active smooth muscle inhibitory factor from bovine retractor penis muscle" Biochemical and Biophysical Research Communications. 164. 544-549 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Aoyame Takeshi: "Prostacyclin halfーlife regulated by HDL is decreased in acute myocardial infarction" Circulation.

    • Related Report
      1989 Annual Research Report
  • [Publications] Morishita Hiroshi: "Increared hydrolysis of cholesteryl ester with prostacyclin is potentiated by HDL through PQI_2stabilization" Journal of Clinical Investigation.

    • Related Report
      1989 Annual Research Report
  • [Publications] Yoshiki Yui;et al.: Journal of Clinical Investigation. 82. 803-807 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takeshi Aoyama;et al.: Journal of Clinical Investigation. (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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