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Effect of vasodilators on the hypoxic pulmonary vasoconstriction

Research Project

Project/Area Number 63570732
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionKinki University

Principal Investigator

UMEDA Takashi (1989-1991)  Kinki University School of Medicine, Medical staff, 医学部・麻酔科, 助手 (10168750)

石部 裕一 (1988)  , 医学部麻酔科学教室, 講師 (40122014)

Co-Investigator(Kenkyū-buntansha) ISHIBE Yuichi  Tottori University School of Medicine, Associate Professor, 医学部・麻酔科, 助教授 (40122014)
楳田 高士  , 医学部麻酔科学教室, 助手 (10168750)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsHPV / PGI_2 / PGE_1 / Halothane / Endotoxin / pressure-flow curve / 肺循環 / HPV(低酸素性肺血管収縮反応) / イブプロフェン / 低酸素性肺血管収縮(HPV) / 圧-流量曲線 / プロスタグランディンE_1 / ニトログリセリン
Research Abstract

1. Using the separatedly ventilated left lower lung model, effects of vasodilators such as nitoroglycerine (TNG) and prostacyclin (PGI_2) on the hypoxic pulumonary vasoconstfiction (HPV) were investigated in the dogs. The results showed that the both TNG and PGI_2 were considered to cause hypoxemia either by increasing pulmonary ventilation-perfusion unevennes because of non-specific vasodilation with TNG or by inhibiting HPV in a dose-related manner with PGI_2.
2. For more precise evaluation of pulmonary vascular tone the new model to measure the vascular pressure-flow curve of the left lower lobe was developed in the dogs in vivo and the effects of inhalation anesthetics such as isofulurane and halothane on HPV were investigated. As the results there were little inhibitory effect of HPV with clinical dose (1-2MAC) of isoflurane and halothane, although both of them inhibited HPV in a dose-related manner when directly inhaled to the hypoxic lobe.
3. Using the same pressure-flow cureve model in the dogs, a dosage of prostagiandin E_1 which decrease systemic blood pressure by 30% was showed to result hypoxemia by inhibiting HPV.
4. Modulation of HPV in the injured lung such as ARDS was investigated with the same pressure-flow curve model in the dogs. Low dose of endotoxin completely depressed HPV and accompanied with a decrese in stable metabolyte of prostacyclin, 6-keto-PGF_1alpha. This depression of HPV with endotoxin was prevented by pretreating with cyclooxgenase inhibitor, ibuprofen and 6-keto-PGF_1alpha did not decreased. These results indicated that incresed release or production of prostacyclin from the pulmonary endothelial cells were involved with the inhibition of HPV by endotoxin.

Report

(4 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 石部 裕一: "プロスタトイクリン(PGI_2)の低酸素性肺血管収縮反応への作用" 麻酔. 38. 1617-1626 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石部 裕一: "低酸素性肺血管収縮" 呼吸. 9. 1430-1439 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石部 裕一: "Effect of endotoxin on the hypoxic pulmonary vasoconstriction in the dogs" Pulmonary Circulation Research (Japanese Society for Pulmonary Circulation Research). 33-36 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石部 裕一: "肺循環,HPV,肺高血圧 特集「麻酔とプロスタグランジル」" 現代医療. 23. 33-41 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 塩川 泰啓: "エンドトキシンの低酸素性肺血管収縮反応への作用" 近畿大医誌. 16. 309-323 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石部 裕一: "圧ー流量曲線によるハロセンのHPV抑制作用の評価" 麻酔. 41. 586-594 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yuichi Ishibe, Masato Nakamura, Takashi Umeda, Takafumi Izumi, Yasuhiro Shiokawa and Keita Suekane: "Effects of Prostacyclin (PGI2) on the hypoxic pulmonary vasoconstriction in dogs" The Japanese Journal of Anesthesiology. 38. 1617-1626 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yuichi Ishibe: "hypoxic pulmonary vasoconstriction" Respiration. 9. 1430-1439 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yuichi Ishibe, Takashi Umeda, Yasuhiro Shiokawa and Keita Suekane: "Effect of endotoxin on the hypoxic pulmonary vasoconstriction in the dogs" Japanese Society for Pulmonary Circulation Research. 33-36 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yuichi Ishibe, Takashi Umeda, Yasuhiro Shiokawa and Keita Suekane: "Pulmonary circulation, hypoxic pulmonary vasoconstriction and Pulmonary hypertention" Gendailryo. 23. 33-36 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yasuhiro Shiokawa: "Effects of endotoxin on hypoxic pulmonary vasoconstriction in dogs" Med J KinkiUniv. 16. 309-323 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yuichi Ishibe, Takashi Umeda, Yasuhiro Shiokawa, Takafumi Izumi, Masato Nakamura, Hiroshi Uno and Keita Suekane: "Evaluation of halothane induced HPV inhibition with analysis of pressure-flow curve" The Japanese Journal of Anesthesiology. 41. 586-594 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 石部裕一: "プロスタサイクリン(PGI_2)の低酸素性肺血管収縮反応への作用" 麻酔. 38. 1619-1626 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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