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MCH neurons ablation improve memory function by function shift

Publicly Offered Research

Project AreaMechanisms underlying the functional shift of brain neural circuitry for behavioral adaptation
Project/Area Number 17H05563
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

山中 章弘  名古屋大学, 環境医学研究所, 教授 (60323292)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords視床下部 / MCH神経 / 記憶 / マウス / アデノ随伴ウイルスベクター / 光遺伝学 / 化学遺伝学 / ファイバーフォトメトリー / 睡眠覚醒 / メラニン凝集ホルモン / 薬理遺伝学 / 電気生理学
Outline of Annual Research Achievements

遺伝子操作によって記憶力が悪くなる動物はたくさん存在するが、記憶力が良くなる例は数少ない。メラニン凝集ホルモン産生神経(MCH神経)は、視床下部だけに少数の細胞体が存在し、睡眠中に活性化される。MCH神経の生理的役割解明のために、MCH神経を時期特異的に脱落させたマウスを作成したところ、記憶が有意に良くなることを見いだした。このことは、レム睡眠中のMCH神経活動が、記憶抑制・消去に関わっていることを示している。本研究では、MCH神経脱落により、神経回路の機能シフトが生じ、記憶が向上するメカニズムに迫り、睡眠と記憶消去との関係も明らかにすることを目的としている。MCH神経の活動を光遺伝学、化学遺伝学にて操作可能なマウスを作出し、神経活動操作を行った。その結果、MCH神経活動を活性化させると、海馬依存的な記憶が阻害・消去されること、逆に抑制すると記憶が向上することを見いだした。これらの結果から、MCH神経活動が海馬において記憶制御に関わっていることを示している。さらに、MCH神経活動をカルシウムインジケータであるGCaMP6を用いてインビボ記録するファイバーフォトメトリーを適用し、脳波筋電図記録による睡眠解析と同時に行ったところ、MCH神経活動がレム睡眠中、覚醒中に高くなることを見いだした。そこで、MCH神経活動をレム睡眠中、覚醒時それぞれにおいて光遺伝学で抑制を行った。その結果、レム睡眠中のMCH神経活動を抑制すると海馬依存的な記憶に影響があることを見いだした。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (82 results)

All 2019 2018 2017 2015

All Journal Article (29 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 25 results,  Open Access: 16 results) Presentation (53 results) (of which Int'l Joint Research: 14 results,  Invited: 53 results)

  • [Journal Article] Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo2019

    • Author(s)
      Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, *Yawo H
    • Journal Title

      J Physiol Sci

      Volume: 69(1) Issue: 1 Pages: 65-77

    • DOI

      10.1007/s12576-018-0618-4

    • NAID

      40021804699

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles2019

    • Author(s)
      Toh Miyazaki, Srikanta Chowdhury, Takayuki Yamashita, Takanori Matsubara, Hiromu Yawo, Hideya Yuasa and Akihiro Yamanaka
    • Journal Title

      Cell Reports

      Volume: 26 Issue: 4 Pages: 1033-1043

    • DOI

      10.1016/j.celrep.2019.01.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. 2019 (in press)2019

    • Author(s)
      Macpherson T, Mizoguchi H, Yamanaka A, Hikida T
    • Journal Title

      Neurochem Int

      Volume: 126 Pages: 11-18

    • DOI

      10.1016/j.neuint.2019.02.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upconversion Amplification through Dielectric Superlensing Modulation2019

    • Author(s)
      Liang L, Teh DBL, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor NV, All AH, Liu X
    • Journal Title

      Nat Commun

      Volume: 10(1) Issue: 1 Pages: 1391-1391

    • DOI

      10.1038/s41467-019-09345-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Opposing roles of dopamine receptor D1- and D2-expressing neurons of the anteromedial olfactory tubercle in acquisition of place preference2019

    • Author(s)
      Koshi Murata, Tomoki Kinoshita, Yugo Fukazawa, Kenta Kobayashi, Akihiro Yamanaka, Takatoshi Hikida, Hiroyuki Manabe, and Masahiro Yamaguchi
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 13 Pages: 50-50

    • DOI

      10.3389/fnbeh.2019.00050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice2019

    • Author(s)
      Zhang Tong、Yanagida Junko、Kamii Hironori、Wada Shintaro、Domoto Masaki、Sasase Hitoki、Deyama Satoshi、Takarada Takeshi、Hinoi Eiichi、Sakimura Kenji、Yamanaka Akihiro、Maejima Takashi、Mieda Michihiro、Sakurai Takeshi、Nishitani Naoya、Nagayasu Kazuki、Kaneko Shuji、Minami Masabumi、Kaneda Katsuyuki
    • Journal Title

      Addiction Biology

      Volume: 印刷中 Issue: 1 Pages: 1-11

    • DOI

      10.1111/adb.12723

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience2018

    • Author(s)
      Miyazaki K*, Miyazaki KW*, Yamanaka A, Tokuda T, Tanaka KF, Doya K *These authors contributed equally to this work.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2048-2048

    • DOI

      10.1038/s41467-018-04496-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Partial ablation of the orexin field induces a sub narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration2018

    • Author(s)
      Black SW,* Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS
    • Journal Title

      Sleep

      Volume: 41(9) Issue: 9

    • DOI

      10.1093/sleep/zsy116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inactivation of Serotonergic Neurons in the Rostral Medullary Raph? Attenuates Stress-Induced Tachypnea and Tachycardia in Mice2018

    • Author(s)
      Ikoma Yoko、Kusumoto-Yoshida Ikue、Yamanaka Akihiro、Ootsuka Youichirou、Kuwaki Tomoyuki
    • Journal Title

      Frontiers in Physiology

      Volume: 9 Pages: 1-16

    • DOI

      10.3389/fphys.2018.00832

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acute aversive stimuli rapidly increase the activity of ventral tegmental area dopamine neurons in awake mice.2018

    • Author(s)
      *Moriya S, Yamashita A, Kawashima S, Nishi R, Yamanaka A, Kuwaki T
    • Journal Title

      Neuroscience

      Volume: 386 Pages: 16-23

    • DOI

      10.1016/j.neuroscience.2018.06.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parallel arousal pathways in the lateral hypothalamus2018

    • Author(s)
      Heiss JE, Yamanaka A, *Kilduff TS
    • Journal Title

      eNeuro

      Volume: 5(4) Issue: 4 Pages: 0228-18

    • DOI

      10.1523/eneuro.0228-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys2018

    • Author(s)
      Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, *Ushiba J, *Okano H
    • Journal Title

      Cell Rep

      Volume: 24(8) Issue: 8 Pages: 2191-2195

    • DOI

      10.1016/j.celrep.2018.07.057

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy2018

    • Author(s)
      Thannickal Thomas C.、John Joshi、Shan Ling、Swaab Dick F.、Wu Ming-Fung、Ramanathan Lalini、McGregor Ronald、Chew Keng-Tee、Cornford Marcia、Yamanaka Akihiro、Inutsuka Ayumu、Fronczek Rolf、Lammers Gert Jan、Worley Paul F.、Siegel Jerome M.
    • Journal Title

      Science Translational Medicine

      Volume: 10 Issue: 447 Pages: 447-447

    • DOI

      10.1126/scitranslmed.aao4953

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice2018

    • Author(s)
      Matsui Sho、Sasaki Tsutomu、Kohno Daisuke、Yaku Keisuke、Inutsuka Ayumu、Yokota-Hashimoto Hiromi、Kikuchi Osamu、Suga Takayoshi、Kobayashi Masaki、Yamanaka Akihiro、Harada Akihiro、Nakagawa Takashi、Onaka Tatsushi、Kitamura Tadahiro
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1-17

    • DOI

      10.1038/s41467-018-07033-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia2018

    • Author(s)
      Futatsuki Takahiro、Yamashita Akira、Ikbar Khairunnisa Novita、Yamanaka Akihiro、Arita Kazunori、Kakihana Yasuyuki、Kuwaki Tomoyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2717-2717

    • DOI

      10.1038/s41598-018-21252-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors.2018

    • Author(s)
      Suda Y, Kuzumaki N, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T, Yamanaka A, Narita M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 496 Issue: 4 Pages: 1102-1108

    • DOI

      10.1016/j.bbrc.2018.01.145

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer2018

    • Author(s)
      Watanabe Moe、Narita Michiko、Hamada Yusuke、Yamashita Akira、Tamura Hideki、Ikegami Daigo、Kondo Takashige、Shinzato Tatsuto、Shimizu Takatsune、Fukuchi Yumi、Muto Akihiro、Okano Hideyuki、Yamanaka Akihiro、Tawfik Vivianne L、Kuzumaki Naoko、Navratilova Edita、Porreca Frank、Narita Minoru
    • Journal Title

      Molecular Pain

      Volume: 14 Pages: 1-10

    • DOI

      10.1177/1744806918756406

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system2018

    • Author(s)
      Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M
    • Journal Title

      Molecular Pain

      Volume: 14 Pages: 1-10

    • DOI

      10.1177/1744806918754934

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sex differences in olfactory-induced neural activation of the amygdala.2018

    • Author(s)
      Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE 3rd, Mogi K.
    • Journal Title

      Behav Brain Res.

      Volume: 27 Pages: 96-104

    • DOI

      10.1016/j.bbr.2017.11.034

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons.2017

    • Author(s)
      Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, *Mendelowitz D.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 312 Issue: 4 Pages: H808-H817

    • DOI

      10.1152/ajpheart.00572.2016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lateral hypothalamic circuits for sleep-wake control.2017

    • Author(s)
      Yamashita T, *Yamanaka A.
    • Journal Title

      Current Opinion in Neurobiology

      Volume: 44 Pages: 94-100

    • DOI

      10.1016/j.conb.2017.03.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic regulation of the sleep/wake cycle.2017

    • Author(s)
      Ono D, *Yamanaka A.
    • Journal Title

      Neurosci Res

      Volume: 118 Pages: 74-81

    • DOI

      10.1016/j.neures.2017.03.013

    • NAID

      120006349128

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オレキシン神経活動操作による機能解明.2017

    • Author(s)
      山中章弘
    • Journal Title

      睡眠医療

      Volume: 11(1) Pages: 19-25

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 光遺伝学による神経科学研究の新展開.2017

    • Author(s)
      山中章弘
    • Journal Title

      医学のあゆみ

      Volume: 262(5) Pages: 491-495

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 光遺伝学による睡眠覚醒の制御.2017

    • Author(s)
      山中章弘
    • Journal Title

      生体の科学

      Volume: 65(5) Pages: 484-485

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 睡眠のマニピュレーション-光遺伝学、薬理遺伝学を用いた睡眠覚醒の操作.2017

    • Author(s)
      山中章弘
    • Journal Title

      医学のあゆみ

      Volume: 263(9) Pages: 765-774

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice2017

    • Author(s)
      Nasanbuyan Naranbat、Yoshida Masahide、Takayanagi Yuki、Inutsuka Ayumu、Nishimori Katsuhiko、Yamanaka Akihiro、Onaka Tatsushi
    • Journal Title

      Endocrinology

      Volume: 159 Issue: 2 Pages: 763-775

    • DOI

      10.1210/en.2017-00606

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Purkinje cells in the mouse cerebellar vermis directly project their axons to medial parabrachial nucleus.2017

    • Author(s)
      Hashimoto, M., Yamanaka, A., Tanifuji, M., Yaginuma, H.
    • Journal Title

      Front Neural Circuit,

      Volume: 12 Pages: 00006-00006

    • DOI

      10.3389/fncir.2018.00006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Challenges in the development of therapeutics for narcolepsy2015

    • Author(s)
      Black SW, Yamanaka A, Kilduff TS
    • Journal Title

      Prog Neurobiol

      Volume: 印刷中 Pages: 89-113

    • DOI

      10.1016/j.pneurobio.2015.12.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 睡眠覚醒調節と記憶の制御に関わる神経の活動記録と操作2019

    • Author(s)
      山中章弘
    • Organizer
      平成30年度生命融合科学教育部シンポジウム 神経科学が解き明かす動物の行動:機能の変容と疾患
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 睡眠覚醒調節神経の機能的同定2019

    • Author(s)
      山中章弘
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Adeno-associated virus vector micro injection into mice brain to reveal function of neural circuitry involved in the regulation of sleep/wakefulness.2019

    • Author(s)
      Yamanaka A
    • Organizer
      FAOPS2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of sleep and memory2018

    • Author(s)
      Yamanaka A
    • Organizer
      第10回光操作研究会・第2回脳情報動態合同国際シンポジウムJoint symposium of 10th Optogenetics Research Conference and Second International Symposium on Brain Information Dynamics 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dissociating orexin-dependent and -independent functions of orexin neurons using novel orexin-Flp knock-in mice2018

    • Author(s)
      Yamanaka A
    • Organizer
      7th International Symposium on Narcolepsy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sleep/wakefulness analysis of orexin and MCH neurons double ablated mice2018

    • Author(s)
      Hung CJ, Ono D, Yamanaka A
    • Organizer
      7th International Symposium on Narcolepsy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Orexin and MCH neurons double ablation mice. Isolation of effect of orexin using orexin-Flippase mice.2018

    • Author(s)
      Yamanaka A
    • Organizer
      7th International Symposium on Narcolepsy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural activity manipulation and behavior control by using fiber-less optogenetics2018

    • Author(s)
      Yamanaka A
    • Organizer
      National University of Singapore, Department of Chemistry, Research Seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulatory mechanism of sleep/wakefulness and memory by the hypothalamic neurons2018

    • Author(s)
      山中章弘
    • Organizer
      島根大学セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 睡眠覚醒調節、痛み調節におけるオレキシンの役割2018

    • Author(s)
      山中章弘
    • Organizer
      第12回日本緩和医療薬学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 睡眠覚醒調節におけるオレキシンの役割2018

    • Author(s)
      山中章弘
    • Organizer
      第41回日本神経科学大会 ランチョンセミナー10
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Role of cholinergic neurons in the septum on the regulation of sleep and memory2018

    • Author(s)
      山中章弘、宮﨑杜夫
    • Organizer
      第41回日本神経科学大会 シンポジウム: 神経修飾物質による脳状態制御: 先進的実験と計算論的アプローチを結ぶ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アップコンバージョンを用いたファイバーレス光遺伝学の開発2018

    • Author(s)
      宮﨑杜夫、Chowdhury Srikanta、山下貴之、八尾 寛、湯浅英哉、山中章弘
    • Organizer
      第56回日本生物物理学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Study of regulatory mechanism of sleep/wakefulness and memory by optogenetical neural activity manipulation2018

    • Author(s)
      山中章弘
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 内側中核アセチルコリン作動性神経による睡眠と記憶の制御2018

    • Author(s)
      山中章弘
    • Organizer
      記憶研究会2018 記憶・学習の基盤機構と回路研究の新展開へのアプローチ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 睡眠と記憶を制御する神経活動の操作と記録2018

    • Author(s)
      山中章弘
    • Organizer
      第8回生理学研究所・名古屋大学医学系研究科合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 睡眠と記憶を制御する神経活動の操作と記録2018

    • Author(s)
      山中章弘
    • Organizer
      星薬科大学セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ファイバーレス光遺伝学を用いた睡眠覚醒と記憶制御のメカニズム解明2018

    • Author(s)
      山中章弘
    • Organizer
      第三回ルミノジェネティクス研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病と睡眠覚醒とのただならぬ関係2018

    • Author(s)
      山中章弘
    • Organizer
      第3回Cortin Conference
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 腹側被蓋野(VTA)のGABA作動性神経はノンレム睡眠を調節する2018

    • Author(s)
      山中章弘
    • Organizer
      平成30年度脳研究所共同利用共同研究合同セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Remote control of deep brain function using scintillation2018

    • Author(s)
      山下貴之
    • Organizer
      遺伝研研究会「哺乳類脳の機能的神経回路の構築メカニズム」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] オレキシンとは?睡眠覚醒調節における役割について.2018

    • Author(s)
      山中章弘
    • Organizer
      第70回九州精神神経学会 第63回九州精神医療学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学、薬理遺伝学による特定神経活動操作を用いた睡眠覚醒、リズム研究.2018

    • Author(s)
      山中章弘
    • Organizer
      時間学特別セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Regulatory mechanism of sleep/wakefulness and memory.2018

    • Author(s)
      Yamanaka A
    • Organizer
      The BRI International Symposium 2018 "The innovative progress of neuroscientific research through the use of advanced animal models"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 起きるべきか?、寝るべきか?、それが問題だ.2018

    • Author(s)
      山中章弘
    • Organizer
      第二回名古屋リズム研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ファイバーレス光遺伝学を用いた神経活動操作と行動制御.2018

    • Author(s)
      山中章弘
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Optogenetics and pharmacogenetics reveals regulatory mechanism of sleep/wakefulness and memory.2017

    • Author(s)
      Yamanaka A
    • Organizer
      Cell biology and systems biology course meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hypothalamic neurons erase memory during sleep.2017

    • Author(s)
      Yamanaka A
    • Organizer
      New York University Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hypothalamic neurons regulate sleep/wakefulness and memory.2017

    • Author(s)
      Yamanaka A
    • Organizer
      Mount Sinai seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The physiological role of orexinergic neurons in the regulation of sleep wakefulness, pain and metabolism.2017

    • Author(s)
      Yamanaka A
    • Organizer
      International Conference of Sleep Medicine and Research (ISSR 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Generation of sleep disorder model mice by ablation of specific types of neurons.2017

    • Author(s)
      Yamanaka A
    • Organizer
      World Sleep
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulatory mechanism of sleep and memory by the hypothalamic neurons.2017

    • Author(s)
      Yamanaka A
    • Organizer
      World Sleep
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulatory mechanism of sleep/wakefulness by the hypothalamic neuropeptide-producing neurons.2017

    • Author(s)
      Yamanaka A
    • Organizer
      120th WPI-IIIS Seminar
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オレキシン神経活動の操作と記録~摂食行動ー睡眠覚醒調節における役割の解明~.2017

    • Author(s)
      山中章弘
    • Organizer
      第15回桜山睡眠研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 視床下部神経による摂食代謝・睡眠覚醒・記憶の制御.2017

    • Author(s)
      山中章弘
    • Organizer
      第27回日本行動神経内分泌研究会 教育講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学・薬理遺伝学を用いた睡眠覚醒と記憶の制御.2017

    • Author(s)
      山中章弘
    • Organizer
      島根大学大学院セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 技術革新が切り拓く最新神経科学研究.2017

    • Author(s)
      山中章弘
    • Organizer
      星薬科大学薬理学教室 平成29年度同門会学術セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学・薬理遺伝学を用いた睡眠覚醒と記憶の制御:メカニズム解明.2017

    • Author(s)
      山中章弘
    • Organizer
      第64回日本実験動物学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 特定神経活動操作で迫る.2017

    • Author(s)
      山中章弘
    • Organizer
      代謝疾患フォーラム2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] アップコンバージョンを用いたファイバーレス光遺伝学の開発と応用.2017

    • Author(s)
      山中章弘
    • Organizer
      第二回ルミノジェネティクス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] オレキシンとは?睡眠覚醒調節における役割ついて.2017

    • Author(s)
      山中章弘
    • Organizer
      Tochigi Insomnia研究会2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] オレキシンとは?睡眠覚醒調節における役割について.2017

    • Author(s)
      山中章弘
    • Organizer
      SLEEP SYMPOSIUM 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 視床下部神経による睡眠覚醒調節と記憶の制御.2017

    • Author(s)
      山中章弘
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ファイバーレス光遺伝学の開発.2017

    • Author(s)
      山中章弘
    • Organizer
      第4回包括的緩和医療科学学術研究会・第5回Tokyo 疼痛緩和次世代研究会 合同研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] オレキシン神経に対するドーパミンの長期的作用の解析.2017

    • Author(s)
      山中章弘、向井康敬
    • Organizer
      第52回日本アルコール・アディクション医学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学・薬理遺伝学を用いた睡眠覚醒調節メカニズムの解明.2017

    • Author(s)
      山中章弘
    • Organizer
      第47回日本小児神経学会小児神経学セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 視床下部神経による睡眠と記憶の制御.2017

    • Author(s)
      山中章弘
    • Organizer
      第47回日本神経精神薬理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] オレキシンとは?睡眠覚醒調節における役割について.2017

    • Author(s)
      山中章弘
    • Organizer
      香川県睡眠治療セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] オレキシンとは?睡眠覚醒調節における役割について.2017

    • Author(s)
      山中章弘
    • Organizer
      第6回世田谷クリニカルフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 視床下部神経による睡眠覚醒・記憶・代謝内分泌調節.2017

    • Author(s)
      山中章弘
    • Organizer
      第42回日本比較内分泌学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光遺伝学・光生理による睡眠覚醒と記憶の制御メカニズム解明.2017

    • Author(s)
      山中章弘
    • Organizer
      日本比較生理生化学会 第39回福岡大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] シングルセル解析による本能行動に関わる視床下部神経回路の機能解明.2017

    • Author(s)
      山中章弘
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ファイバーレス光遺伝学を用いた神経活動操作と行動制御.2017

    • Author(s)
      山中章弘
    • Organizer
      光量子工学研究領域セミナー
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2019-12-27  

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