デフォルトモードネットワークの動作原理と機能解明

• Project Area: Non-linear Neuro-oscillology: Towards Integrative Understanding of Human Nature
• Project/Area Number: 18H04957
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: 林 拓也 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (50372115)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: デフォルトモードネットワーク / 神経画像 / ゆらぎ / 機能的MRI / 安静時機能的MRI / 機能的ネットワーク / 独立成分分析 / 大脳皮質 / ドパミン / セロトニン / 安静時脳機能活動 / デフォルトモード / 共振性活動 / MRI / 自発性活動

Outline of Annual Research Achievements

本研究ではデフォルトモードネットワーク(DMN)がどのいった行動や脳機能を担うのか、DMNが他の神経機構とどのように関連しているか、の二つのアプローチで調べることでDMNの成因や機構を明らかにすることを目的とする。基盤技術としての安静時脳活動・DMNの測定・解析技術の開発を鋭意すすめ、特にマカクサル脳において安静時脳活動機能的MRIを収集する技術（RF受信コイルの条件設定、撮像シーケンス）ならびにネットワーク解析の技術の最適化と開発をすすめ確立し論文化した。撮像シーケンスにはマルチバンドEPIシーケンスを用いて時間解像度0.75秒、空間解像度1.25mmの高い分解能のデータを取得した。空間解像度の決定には、マカクサル脳の皮質厚を計測し半球内の皮質厚分布を基に算出した。また麻酔状態や覚醒状態における脳安静状態のデータ取得・解析を行うための技術も構築した。安静時脳活動MRIデータにおいて問題となるノイズを除去する技術を開発し、機械学習の技術を用いて精度高いノイズ除去技術を構築できた。これにより１９個の神経ネットワークを抽出した。またドパミン機能やセロトニン機能を修飾した際の安静時脳活動ネットワークの調査し、皮質・皮質下の機能ネットワークの変動を認めた。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Oxford University(英国)
• [Int'l Joint Research] Lyon University(フランス)
• [Int'l Joint Research] Washington University in St. Louis(米国)
• [Journal Article] Towards HCP-Style macaque connectomes: 24-Channel 3T multi-array coil, MRI sequences and preprocessing (2020)
  • Author(s): Autio JA, Glasser MF, Ose T, Donahue CJ, Bastiani M, Ohno M, Kawabata Y, Urushibata Y, Murata K, Nishigori K, Yamaguchi M, Hori Y, Yoshida A, Go Y, Coalson TS, Jbabdi S, Sotiropoulos SN, Kennedy H, Smith S, Van Essen DC, Hayashi T.
  • Journal Title: NeuroImage Volume: 215 Pages: 116800-116800
  • DOI: 10.1016/j.neuroimage.2020.116800
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accelerating the Evolution of Nonhuman Primate Neuroimaging (2020)
  • Author(s): Milham Michael、et al
  • Journal Title: Neuron Volume: 105 Issue: 4 Pages: 600-603
  • DOI: 10.1016/j.neuron.2019.12.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diffusion Tensor Model links to Neurite Orientation Dispersion and Density Imaging at high b-value in Cerebral Cortical Gray Matter (2019)
  • Author(s): Fukutomi Hikaru、Glasser Matthew F.、Murata Katsutoshi、Akasaka Thai、Fujimoto Koji、Yamamoto Takayuki、Autio Joonas A.、Okada Tomohisa、Togashi Kaori、Zhang Hui、Van Essen David C.、Hayashi Takuya
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 12246-12246
  • DOI: 10.1038/s41598-019-48671-7
  • NAID: 120007006237
  • Peer Reviewed
• [Journal Article] Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice (2019)
  • Author(s): Van Essen David C.、Donahue Chad J.、Coalson Timothy S.、Kennedy Henry、Hayashi Takuya、Glasser Matthew F.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 52 Pages: 26173-26180
  • DOI: 10.1073/pnas.1902299116
  • Peer Reviewed
• [Journal Article] Premotor Cortical-Cerebellar Reorganization in a Macaque Model of Primary Motor Cortical Lesion and Recovery (2019)
  • Author(s): Yamamoto Tatsuya、Hayashi Takuya、Murata Yumi、Ose Takayuki、Higo Noriyuki
  • Journal Title: The Journal of Neuroscience Volume: 39 Issue: 43 Pages: 8484-8496
  • DOI: 10.1523/jneurosci.0077-19.2019
  • Peer Reviewed / Open Access
• [Journal Article] Does the Diffusion Tensor Model Predict the Neurite Distribution of Cerebral Cortical Gray Matter? ? Cortical DTI-NODDI (2018)
  • Author(s): Hikaru Fukutomi, Matthew F. Glasser, Katsutoshi Murata, Thai Akasaka, Koji Fujimoto, Takayuki Yamamoto, Joonas A. Autio, Tomohisa Okada, Kaori Togashi, Hui Zhang, David C. Van Essen, Takuya Hayashi
  • Journal Title: biorxiv Volume: -
  • DOI: 10.1101/441659
  • Open Access / Int'l Joint Research
• [Journal Article] Neurite imaging reveals microstructural variations in human cerebral cortical gray matter (2018)
  • Author(s): Fukutomi, H., Glasser, M.F., Zhang, H., Autio, J.A., Coalson, T.S., Okada, T., Togashi, K., Van Essen, D.C., and Hayashi, T.
  • Journal Title: Neuroimage Volume: in press Pages: 488-499
  • DOI: 10.1016/j.neuroimage.2018.02.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ. (2018)
  • Author(s): Kii I, Hirahara-Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, Ito H, Takahashi K, Yokoyama C, Hayashi T, Hosoya T, Watanabe Y.
  • Journal Title: Anal Biochem Volume: 549 Pages: 174-183
  • DOI: 10.1016/j.ab.2018.04.001
  • Peer Reviewed / Open Access
• [Presentation] Harmonized Brain MRI Protocols/Preprocessing for Brain/MINDS-beyond (2019)
  • Author(s): Takuya Hayashi
  • Organizer: 3rd Japanese Human Brain Imaging Meeting
  • Invited
• [Presentation] Mapping the Macaque Connectome using High-resolution Multi-modal Imaging in 30 Animals (MacCP 30). (2019)
  • Author(s): Takuya Hayashi et al.
  • Organizer: Annual Meeting of Organization of Human Brain Mapping
  • Int'l Joint Research
• [Presentation] ヒト脳の解明のための霊長類脳コネクトーム研究 (2019)
  • Author(s): Hayashi Takuya
  • Organizer: 第21回日本ヒト脳機能マッピング学会
• [Presentation] Towards the Macaque Connectome: 24-Channel 3T Multi-Array Coil, MR Sequences, and HCP-style Preprocessing (2018)
  • Author(s): Autio Joonas, Ose Takayuki, Ohno Masahiro, Kawabata Yoshihiko, Urushibata Yuta , Nishigori Kantaro, Yamaguchi Masataka, Hori Yuki, Yoshida Atsushi, Murata Katsutoshi, Glasser Matthew F, Hayashi Takuya.
  • Organizer: ISMRM2018
• [Presentation] Resting state functional corticostriatal connectivity in Parkinsonian monkeys (2018)
  • Author(s): Autio Joonas, Ose Takayuki, Nishigori Kantaro, Tanki Nobuyoshi, Takahashi Jun, Glasser Matthew F, Hayashi Takuya
  • Organizer: ISMRM2018
• [Presentation] Development of a 24-Channnel 3T Multi-Array Coil for functional MRI in awake monkeys (2018)
  • Author(s): Yoshida Atsushi, Hori Yuki, Nishigori Kantaro, Ohno Masahiro, Kawabata Yoshihiko, Murata Katsutoshi, Urushibata Yuta , Yamaguchi Masataka, Autio Joonas, Glasser Matthew F, Hayashi Takuya
  • Organizer: ISMRM2018
• [Presentation] Translating the Human Connectome Project to Marmoset Imaging (2018)
  • Author(s): Hori Yuki, Autio Joonas, Ohno Masahiro, Kawabata Yoshihiko, Urushibata Yuta , Murata Katsutoshi, Yamaguchi Masataka, Kawasaki Akihiro, Takeda Chiho, Yokoyama Chihiro, Glasser Matthew F, Hayashi Takuya
  • Organizer: ISMRM2018
• [Presentation] Resting State Functional CorticoStriatal Connectivity in Parkinsonian Monkeys (2018)
  • Author(s): Autio Joonas, Nishigori Kantaro, Tanki Nobuyoshi, Yamaguchi Masataka, Takahashi Jun, Glasser Matthew F, Hayashi Takuya
  • Organizer: 第41回日本神経科学学会
• [Presentation] Resting state functional corticostriatal connectivity in Parkinsonian monkeys (2018)
  • Author(s): Autio Joonas, Ose Takayuki, Nishigori Kantaro, Tanki Nobuyoshi, Takahashi Jun, Glasser Matthew F, Hayashi Takuya
  • Organizer: 第2回ヒト脳イメージング研究会
• [Presentation] Development of a 24-Channel Multi-Array Coil for functional MRI at 3T in awake macaques (2018)
  • Author(s): Yoshida Atsushi, Hori Yuki, Nishigori Kantaro, Ohno Masahiro, Kawabata Yoshihiko, Urushibata Yuta , Murata Katsutoshi, Yamaguchi Masataka, Autio Joonas, Glasser Matthew F, Hayashi Takuya
  • Organizer: 第2回ヒト脳イメージング研究会
• [Presentation] Dopaminergic modulation of functional connectome in anesthetized macaque monkeys (2018)
  • Author(s): Nishigori Kantaro, Ose Takayuki, Ohno Masahiro, Yamaguchi Masataka, Autio Joonas, Yoshida Atsushi, Negishi Toru, NAKAZAWA Shunsuke, urushino Naoko, Ichihara Junji, Hayashi Takuya
  • Organizer: 第2回ヒト脳イメージング研究会
• [Presentation] Translating Human Connectome Project to Marmoset Imaging (2018)
  • Author(s): Hori Yuki, Autio Joonas, Ohno Masahiro, Kawabata Yoshihiko, Urushibata Yuta , Murata Katsutoshi, Kawasaki Akihiro, Takeda Chiho, Yokoyama Chihiro, Yamaguchi Masataka, Yoshida Atsushi, Glasser Matthew F, Van Essen David, Hayashi Takuya
  • Organizer: 第2回ヒト脳イメージング研究会
• [Presentation] Prediction of Neurite Indices From Diffusion Tensor Imaging in the human cerebral cortex (2018)
  • Author(s): Fukutomi Hikaru, Akasaka Thai, Fujimoto Koji, Yamamoto Takayuki, Okada Tomohisa, Kaori Togashi, Hayashi Takuya
  • Organizer: ISMRM2018
• [Presentation] Does Diffusion Tensor Model Predict Neurite Distribution of Cerebral Cortical Gray Matter? ? Cortical DTI-NODDI (2018)
  • Author(s): Fukutomi Hikaru, Murata Katsutoshi, Glasser Matthew F, Akasaka Thai, Fujimoto Koji, Yamamoto Takayuki, Autio Joonas, Okada Tomohisa, Kaori Togashi, Zhang Gary Hui, Van Essen David, Hayashi Takuya
  • Organizer: 第2回ヒト脳イメージング研究会
• [Presentation] 霊長類脳コネクトームと病態解明 (2018)
  • Author(s): Hayashi Takuya
  • Organizer: 第9回札幌神経科学研究会
• [Presentation] Age-dependent changes of structure, myelin and neurite in adult human cerebral cortex (2018)
  • Author(s): Sasaki Akihiro, Fukutomi Hikaru, watanabe kyosuke, Morito Yusuke, Tajima Kanako, Ebisu Kyoko, Iwasaki Miho, Mizuno Kei, Hayashi Takuya, Watanabe Yasuyoshi
  • Organizer: 第2回ヒト脳イメージング研究会