高分子コロイド分散系における動的秩序の構築

• Project Area: Dynamical ordering of biomolecular systems for creation of integrated functions
• Project/Area Number: 26102517
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Shinshu University
• Principal Investigator: 鈴木 大介 信州大学, 学術研究院繊維学系, 准教授 (90547019)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 高分子微粒子 / コロイド / ゲル

Outline of Annual Research Achievements

自律駆動微粒子の振動周期を制御するために、新たに親水性のアクリルアミドを共重合した微粒子、より高い下限臨界共溶温度を有するpoly(N-isopropylmethacrylamide) (pNIPMAm, LCST 38-44 °C)やpoly(N-ethylacrylamide) (pNEAm, LCST 72 °C)を主骨格とした微粒子を合成した。これらの微粒子を用い、まず、化学振動反応条件を精査し、最短振動周期が得られる基質濃度を決定し、続いて、振動挙動の温度依存性を検討する事で、アクリルアミド共重合微粒子が、これまでの報告に比べ、振動可能温度域を約1.9倍増大し(31 °C)、振動周期は約3.3倍(7.9 s)の短縮化を実現した。
以上で得た微粒子間を連結するために、新たにアミノ基を微粒子に導入し、そこを足場に微粒子間を架橋し、バルク体を形成した。バルク体の振動周期も、微粒子分散系と同程度まで短縮することができ、応用範囲の拡大につなげることができた。
その他に、サイズの影響を見るために、生体内分子等と同程度の微粒子を合成し、２次元基板上における動的秩序形成の構築を試みた。マイカ基板上に高分子鎖・微粒子を固定化させ、水中で揺動する様を、原子間力顕微鏡法を駆使することで達成することができた。しかし、溶液中で確認されている、微粒子が周期的に離合集散するような動的秩序構造の形成までは、２次元基板上では確認するに至っておらず、継続課題における解決すべき課題の一つだと考えている。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Direct visualization of swollen microgels via scanning electron microscopy using ionic liquids (2016)
  • Author(s): Koji Horigome, Takeshi Ueki, Daisuke Suzuki
  • Journal Title: Polym. J. Volume: 48 Issue: 3 Pages: 273-279
  • DOI: 10.1038/pj.2015.103
  • Peer Reviewed
• [Journal Article] Localization of Polystyrene Particles on the Surface of Poly(N-isopropylacrylamide-co-methacrylic acid) Microgels Prepared by Seeded Emulsion Polymerization of Styrene (2016)
  • Author(s): Chiaki Kobayashi, Takumi Watanabe, Kazuyoshi Murata, Takuma Kureha, and Daisuke Suzuki
  • Journal Title: Langmuir Volume: 32 Issue: 6 Pages: 1429-1439
  • DOI: 10.1021/acs.langmuir.5b03698
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Investigation of Changes in the Microscopic Structure of Anionic Poly(N-isopropylacrylamide-co-Acrylic acid) Microgels in the Presence of Cationic Organic Dyes toward Precisely Controlled Uptake/Release of Low-Molecular-Weight Chemical Compound (2016)
  • Author(s): Takuma Kureha, Takahisa Shibamoto, Shusuke Matsui, Takaaki Sato, and Daisuke Suzuki
  • Journal Title: Langmuir Volume: in press Issue: 18 Pages: 4575-4585
  • DOI: 10.1021/acs.langmuir.6b00760
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Small-angle X-ray Scattering Study on Internal Microscopic Structures of Poly(N-isopropylacrylamide-co-tris(2,2′-bipyridyl))ruthenium(II) Complex Microgels (2015)
  • Author(s): Shusuke Matsui, Takuma Kureha, Yasuhisa Nagase, Kosuke Okeyoshi, Ryo Yoshida, Takaaki Sato, and Daisuke Suzuki
  • Journal Title: Langmuir Volume: 31 Issue: 26 Pages: 7228-7237
  • DOI: 10.1021/acs.langmuir.5b01164
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Autonomously Oscillating Microgels and Microgel Assemblies with Higher frequency (2016)
  • Author(s): Shusuke Matsui, Yuki Sakurai, Yuki Kumai, Ryo, Yoshida, Takuma, Kureha, Daisuke, Suzuki
  • Organizer: 第65回高分子年次大会
  • Place of Presentation: 神戸国際会議場・展示場、兵庫
  • Year and Date: 2016-05-25
• [Presentation] Synthesis and Properties of Hydrogel Particles Prepared with Cyclodextrin type Pseudo-Polyrotaxane Cross-linkers (2015)
  • Author(s): Daichi Aoki, Seina Hiroshige, Takuma Kureha, Keisuke Iijima, Daisuke Aoki, Toshikazu Takata and Daisuke Suzuki
  • Organizer: The 4th International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
  • Place of Presentation: 九州大学 西新プラザ(Fukuoka, Japan)
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Microscopic Structural Changes in Hydrogel Particles in the presence of Target Molecules investigated by Small- and Wide-Angle X-ray Scattering (2015)
  • Author(s): Takuma Kureha, Takaaki Sato and Daisuke Suzuki
  • Organizer: The 4th International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
  • Place of Presentation: 九州大学 西新プラザ(Fukuoka, Japan)
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Control of Spatio-temporal Structures for Polymeric Hydrogel Microspheres (2015)
  • Author(s): Daisuke Suzuki
  • Organizer: The 5th Asian Symposium on Emulsion Polymerization and Functional Polymeric Microspheres (ASEPFPM)
  • Place of Presentation: Jinji Lake Hotel, Suzhou, China
  • Year and Date: 2015-10-25
  • Int'l Joint Research / Invited
• [Presentation] 環境応答型高分子ゲル微粒子の構造と機能設計 (2015)
  • Author(s): 鈴木大介
  • Organizer: 計測自動制御学会中部支部シンポジウム
  • Place of Presentation: 信州大学繊維学部、長野
  • Year and Date: 2015-09-24
  • Invited
• [Presentation] Control of Spatio-Temporal Structures for Polymer Microspheres toward Advanced Soft Materials (2015)
  • Author(s): Daisuke Suzuki
  • Organizer: IMS Asian International Symposium
  • Place of Presentation: 分子科学研究所(愛知県岡崎市)
  • Year and Date: 2015-06-13
  • Int'l Joint Research / Invited
• [Presentation] Assembly of Stimuli Responsive Polymer Colloids (2015)
  • Author(s): Daisuke Suzuki, Masaki Murai, Haruka Minato and Koji Horigome:
  • Organizer: The 3rd International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
  • Place of Presentation: Nemuno Sato Hotel & Resort, Mie, Japan
  • Year and Date: 2015-01-11
• [Presentation] Cluster Formation using Oscillating Microgels (2015)
  • Author(s): Masaki Murai, Haruka Minato, Koji Horigome and Daisuke Suzuki
  • Organizer: The 3rd International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
  • Place of Presentation: Nemuno Sato Hotel & Resort, Mie, Japan
  • Year and Date: 2015-01-10
• [Presentation] RELATIONSHIP BETWEEN OSCILLATION BEHAVIOR AND INTERNAL STRUCTURE OF OSCILLATING MICROGELS INVESTIGATED BY SMALL-ANGLE X-RAY SCATTERING (2015)
  • Author(s): Shusuke Matsui, Takuma Kureha, Kosuke Okeyoshi, Ryo Yoshida, Takaaki Sato and Daisuke Suzuki
  • Organizer: The 3rd International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
  • Place of Presentation: Nemuno Sato Hotel & Resort, Mie, Japan
  • Year and Date: 2015-01-10
• [Presentation] Relationship between Temperature-Induced Changes in Internal Structures of Hydrogel Particles and Low Molecular Uptake Behavior (2015)
  • Author(s): Takuma Kureha, Takaaki Sato and Daisuke Suzuki
  • Organizer: The 3rd International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
  • Place of Presentation: Nemuno Sato Hotel & Resort, Mie, Japan
  • Year and Date: 2015-01-10