Structure
Volume 20, Issue 3, 7 March 2012, Pages 440-449
ArticleMechanistic Insights into the Activation of Rad51-Mediated Strand Exchange from the Structure of a Recombination Activator, the Swi5-Sfr1 Complex
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Highlights
► Swi5 and the C-terminal core domain of Sfr1 form an essential activator complex ► The crystal structure of the Swi5-Sfr1 complex reveals an unusual kinked structure ► The molecular shape is suited to a snug fit into the groove of the Rad51 filament ► The N-terminal region of Sfr1 has an interface for binding of Rad51
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These authors contributed equally to this work
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Present address: Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK
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