原虫感染における含硫アミノ酸代謝の役割

• 研究領域: 感染現象のマトリックス
• 研究課題/領域番号: 18073001
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 国立感染症研究所 (2008-2010); 群馬大学 (2006-2007)
• 研究代表者: 野崎 智義 国立感染症研究所, 寄生動物部, 部長 (60198588)
• 研究分担者: VAHAB Ali 群馬大学, 大学院・医学系研究科, 助教 (20400757) ; 津久井 久美子 国立感染症研究所, 寄生動物部, 主任研究官 (00420092) ; 佐藤 暖 慶応義塾大学, 先端生命科学研究所, 特別研究助教 (50468477)
• 研究期間 (年度): 2006 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 90,000千円 (直接経費: 90,000千円); 2010年度: 18,000千円 (直接経費: 18,000千円); 2009年度: 18,000千円 (直接経費: 18,000千円); 2008年度: 18,000千円 (直接経費: 18,000千円); 2007年度: 18,000千円 (直接経費: 18,000千円); 2006年度: 18,000千円 (直接経費: 18,000千円)
• キーワード: 含硫アミノ酸 / 代謝 / 感染症 / メタボローム / トランスクリプトーム / 赤痢アメーバ / 含流アミノ酸 / 寄生虫 / 代謝学 / メタボロミクス / トランスクリプトミクス / 寄生 / 感染 / 病原機構

研究概要

原虫感染症における代謝の役割を明らかにすることを目的に、赤痢アメーバをモデルとして、その代謝機構を、メタボローム・トランスクリプトーム等のオミクス手法を用いて、俯瞰的に解析した。システイン負荷・飢餓ストレスに応答する代謝変化、並びに、細胞分化に伴う代謝変化、更にそれらの変化に伴う遺伝子発現変化などを統合的に解明した。その結果、これまで全く知られていない新しい酸化ストレス応答代謝経路や代謝産物が同定された。また、嚢子化に伴う代謝フラックス、及び遺伝子発現の調節が明らかにされた。以上、原虫におけるオミクス解析による統合的代謝解析系は充分に構築された。

研究成果

• [雑誌論文] Mechanism of trifluoromethionine resistance in Entamoeba histolytica. (2011)
  • 著者名/発表者名: Penuliar, G. M., Furukawa, A., Sato, D., and Nozaki, T.
  • 雑誌名: J. Antimicrob. Chemother. 巻: 66 ページ: 2045-2052
• [雑誌論文] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica. (2011)
  • 著者名/発表者名: Mi-ichi, F., Makiuchi, T., Furukawa, A., Sato, D., Nozaki, T.
  • 雑誌名: PLoS Neglect. Trop. Dis. 巻: 5
• [雑誌論文] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica (2011)
  • 著者名/発表者名: Husain, A., Jeelani, G., Sato, D., Nozaki, T.
  • 雑誌名: BMC Genomics 巻: 12 ページ: 275-275
  • 査読あり
• [雑誌論文] Mechanism of trifluoromethionine resistance in Entamoeba histolytica (2011)
  • 著者名/発表者名: Penuliar, G.M., Furukawa, A., Sato, D., Nozaki, T.
  • 雑誌名: J.Antimicrob.Chemother. 巻: 66 ページ: 2045-2052
  • 査読あり
• [雑誌論文] Cytotoxic effect of amide derivatives of trifluoromethionine to the enteric protozoan parasite Entamoeba histolytica. (2010)
  • 著者名/発表者名: Sato., D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., and Nozaki, T.
  • 雑誌名: Int. J. Antimicrob. Agents. 巻: 35 ページ: 56-61
• [雑誌論文] Bacterial-type oxygen detoxification and iron-sulphur cluster assembly in amoebal relict mitochondria Cell. (2010)
  • 著者名/発表者名: Maralikova, B., Ali, V., Nakada-Tsukui, K., Nozaki, T., van der Giezen, M., Henze, K., and Tovar, J.
  • 雑誌名: Microbiol. 巻: 12 ページ: 331-342
• [雑誌論文] Characterization of two isotypes of L-threonine dehydratase from Entamoeba histolytica (2010)
  • 著者名/発表者名: Husain, A., Jeelani, G., Sato, D., Ali, V,, and Nozaki, T.
  • 雑誌名: Mol. Biochem. Parasitol. 巻: 170 ページ: 100-104
• [雑誌論文] Localization and targeting of unusual pyridine nucleotide transhydrogenase in Entamoeba histolytica. (2010)
  • 著者名/発表者名: Yousuf, M. A., Mi-ichi, F., Nakada-Tsukui, K., and Nozaki, T.
  • 雑誌名: Eukaryot. Cell 巻: 9 ページ: 926-933
• [雑誌論文] Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica. (2010)
  • 著者名/発表者名: Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., and Nozaki, T.
  • 雑誌名: J. Biol. Chem. 巻: 285 ページ: 39160-39170
• [雑誌論文] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica. (2010)
  • 著者名/発表者名: Husain, A., Jeelani, G., Sato, D., and Nozaki, T.
  • 雑誌名: BMC Genomics 巻: 12 ページ: 275-275
• [雑誌論文] Cytotoxic effect of amide derivatives of trifluoromethionine to the enteric protozoan parasite Entamoeba histolytica (2010)
  • 著者名/発表者名: Sato., D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., Nozaki, T.
  • 雑誌名: Int.J.Antimicrob.Agents. 巻: 35 ページ: 56-61
  • 査読あり
• [雑誌論文] (2010) Bacterial-type oxygen detoxification and iron-sulphur cluster assembly in amoebal relict mitochondria (2010)
  • 著者名/発表者名: Maralikova, B., Ali, V., Nakada-Tsukui, K., Nozaki, T., van der Giezen, M., Henze, K., Tovar, J.
  • 雑誌名: Cell.Microbiol. 巻: 12 ページ: 331-342
  • 査読あり
• [雑誌論文] Characterization of two isotypes of L-threonine dehydratase from Entamoeba histolytica (2010)
  • 著者名/発表者名: Husain, A., Jeelani, G., Sato, D., Ali, V., Nozaki, T.
  • 雑誌名: Mol.Biochem.Parasitol. 巻: 170 ページ: 100-104
  • 査読あり
• [雑誌論文] Localization and targeting of unusual pyridine nucleotide transhydrogenase in Entamoeba histolytica (2010)
  • 著者名/発表者名: Yousuf, M.A., Mi-ichi, F., Nakada-Tsukui, K., Nozaki, T.
  • 雑誌名: Eukaryot.Cell 巻: 9 ページ: 926-933
  • 査読あり
• [雑誌論文] Conservation and function of Rab small GTPases in Entamoeba : annotation of E.invadens Rab and its use for the understanding of Entamoeba biology (2010)
  • 著者名/発表者名: Nakada-Tsukui, K., Saito-Nakano, Y., Husain, A., Nozaki, T.
  • 雑誌名: Exp.Parasitol. 巻: 126(Review) ページ: 337-347
  • 査読あり
• [雑誌論文] Two Atypical L-cysteine-regulated NADPH-dependent oxidoreductases involved in redox maintenance, L-cystine reduction, and metronidazole activation in the enteric protozoon Entamoeba histolytica (2010)
  • 著者名/発表者名: Jeelani, G., Husain, A., Sato, D., Ali, V., Suematsue, M., Soga, T., Nozaki, T.
  • 雑誌名: J.Biol.Chem. 巻: 285 ページ: 26889-26899
  • 査読あり
• [雑誌論文] Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica (2010)
  • 著者名/発表者名: Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T.
  • 雑誌名: J.Biol.Chetn. 巻: 285 ページ: 39160-39170
  • 査読あり
• [雑誌論文] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica (2010)
  • 著者名/発表者名: Mi-ichi, F., Makiuchi, T., Furukawa, A., Sato, D., Nozaki, T.
  • 雑誌名: PLoS Negl.Trop.Dis. 巻: 5
  • 査読あり
• [雑誌論文] Cytotoxic effect of amide derivatives of trifluoromethionine to the enteric protozoan parasite Entamoeba histolytica. (2010)
  • 著者名/発表者名: Sato, D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., Nozaki, T.
  • 雑誌名: Int.J.Antimicrob.Agents. 巻: 35 ページ: 56-61
  • 査読あり
• [雑誌論文] Bacterial-type oxygen detoxification and iron-sulphur cluster assembly in amoebal relict mitochondria Cell. (2010)
  • 著者名/発表者名: Maralikova, B., Ali, V., Nakada-Tsukui, K., Nozaki, T., van der Giezen, M., Henze, K., Tovar, J.
  • 雑誌名: Microbiol 巻: 12 ページ: 331-342
  • 査読あり
• [雑誌論文] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica. (2009)
  • 著者名/発表者名: Hussain, S., Ali, V., Jeelani, G., and Nozaki, T.
  • 雑誌名: Mol. Biochem. Parasitol. 巻: 163 ページ: 39-47
• [雑誌論文] Methionine gamma-lyase: the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers.(Review) (2009)
  • 著者名/発表者名: Sato, D. and Nozaki, T.
  • 雑誌名: IUBMB Life 巻: 61 ページ: 1019-1028
• [雑誌論文] Mitosomes in Entamoeba histolytica contain a sulfate activation pathway. (2009)
  • 著者名/発表者名: Mi-ichi, F., Yousuf, M. A., Nakada-Tsukui, K., and Nozaki, T.
  • 雑誌名: Proc. Natl. Acad. Sci. USA. 巻: 106 ページ: 21731-21736
• [雑誌論文] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica. (2009)
  • 著者名/発表者名: Hussain, S., Ali, V., Jeelani, G., Nozaki, T.
  • 雑誌名: Mol.Biochem.Parasitol. 巻: 163 ページ: 39-47
  • 査読あり
• [雑誌論文] Methionine gamma-lyase : the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers. (2009)
  • 著者名/発表者名: Sato, D., Nozaki, T.
  • 雑誌名: IUBMB Life 巻: 61 ページ: 1019-1028
  • 査読あり
• [雑誌論文] Mitosomes in Entamoeba histolytica contain a sulfate activation pathway. (2009)
  • 著者名/発表者名: Mi-ichi, F., Yousuf, M.A., Nakada-Tsukui, K., Nozaki, T.
  • 雑誌名: Proc.Natl.Acad.Sci.USA. 巻: 106 ページ: 21731-21736
  • 査読あり
• [雑誌論文] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica. (2009)
  • 著者名/発表者名: Hussain, S., Ali, V., Jeelani, G., Nozaki, T.
  • 雑誌名: Mol. Biochem. Parasitol. 163 ページ: 39-47
• [雑誌論文] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis. (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Harada, S., and Nozaki, T.
  • 雑誌名: FEBS J. 巻: 275 ページ: 548-560
• [雑誌論文] Crystallization and preliminary X-ray analysis of L-methionine γ -lyase 1 from Entamoeba histolytica. (2008)
  • 著者名/発表者名: Sato, D., Karaki, T., Shimizu, A., Kamei, K., Harada, S., and Nozaki, T.
  • 雑誌名: Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 巻: 64 ページ: 697-699
• [雑誌論文] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis. (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Harada, S., Nozaki, T.
  • 雑誌名: FEBS J. 275 ページ: 548-560
• [雑誌論文] Crystallization and preliminary X-ray analysis of L-methionineγ-lyase 1 from Entamoeba histolytica. (2008)
  • 著者名/発表者名: Sato, D., Karaki, T., Shimizu, A., Kamei, K., Harada, S., Nozaki, T.
  • 雑誌名: Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 ページ: 697-699
• [雑誌論文] "Inject-mix-react-separate-and-quan titate" method for High-throughput screening of enzyme Inhibitors. (2008)
  • 著者名/発表者名: Wong, E., Okhonin, V., Berezovski, M., Nozaki, T., Alexandrov, K., Krylov, S.
  • 雑誌名: J. Am. Chem. Soc. 130 ページ: 11862-11863
• [雑誌論文] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound aaainst amoebiasis. (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Harada, S., and Nozaki, T.
  • 雑誌名: FEBS J. 275, ページ: 548-560
  • 査読あり
• [雑誌論文] Crystallization and preliminary X-ray analysis of L-methionine γ-lyase 1 from Entamoeba histolytica. Acta Crystallogr. (2008)
  • 著者名/発表者名: Sato, D., Karaki, T., Shimizu, A., Kamei, K., Harada, S., and Nozaki, T.
  • 雑誌名: Sect. F Struct. Biol. Cryst. Commun. 64 ページ: 697-699
  • 査読あり
• [雑誌論文] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica. (2008)
  • 著者名/発表者名: Hussain, S., Ali, V., Jeelani, G., and Nozaki, T.
  • 雑誌名: Mol. Biochem. Parasitol. 163 ページ: 39-47
  • 査読あり
• [雑誌論文] "Inject-mix-react-separate-and-quantitate" method for High-throughput screening of enzyme Inhibitors. (2008)
  • 著者名/発表者名: Wong, E., Okhonin, V., Berezovski, M., Nozaki, T, Alexandrov, K., and Krylov, S.
  • 雑誌名: J. Am. Chem. Soc. 130 ページ: 11862-11863
  • 査読あり
• [雑誌論文] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis. (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Harada, S., and Nozaki, T.
  • 雑誌名: FEBS J. 275 ページ: 548-560
  • 査読あり
• [雑誌論文] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites. (2007)
  • 著者名/発表者名: Ali. V. and Nozaki, T.
  • 雑誌名: Clin. Microbiol. Rev. 巻: 20 ページ: 164-187
• [雑誌論文] Structure and content of the Entamoeba histolytica genome. (2007)
  • 著者名/発表者名: Clark, C.G., Cecilia, U., Alsmark, M., Hofer, M., Saito-Nakano, Y., Ali, V., Marion, S., Weber, C., Mukherjee, C., Bruchhaus, I., Tannich, E., Leippe, M., Sicheritz-Ponten, T., Foster, P. G., Samuelson, J., Noel, C. J., Hirt, R. P., Embley, T. M., Gilchrist, C. A., Mann, B. J., Singh, U., Ackers, J. P., Bhattacharya, S., Bhattacharya, A., Lohia. A., Guillen, N., Duchene, M., Nozaki, T., and Hall, N.
  • 雑誌名: Adv. Parasitol. 巻: 65 ページ: 51-190
• [雑誌論文] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites. (2007)
  • 著者名/発表者名: Ali. V., Nozaki, T.
  • 雑誌名: Clin. Microbiol. Rev. 20 ページ: 164-187
• [雑誌論文] Structure and content of the Entamoeba histolyticagenome. (2007)
  • 著者名/発表者名: Clark, C.G., Cecilia, U., Alsmark, M., Hofer, M., Saito-Nakano, Y., Ali, V., Marion, S., Weber, C., Mukherjee, C., Bruchhaus, I., Tannich, E., Leippe, M., Sicheritz-Ponten, T., Foster, P.G., Samuelson, J., Noel, C.J., Hirt, R.P., Embley, T.M., Gilchrist, C.A., Mann, B.J., Singh, U., Ackers, J.P., Bhattacharya, S., Bhattacharya, A., Lohia. A., Guillen, N., Duchene, M., Nozaki, T., Hall, N.
  • 雑誌名: Adv. Parasitol. 65 ページ: 51-190
• [雑誌論文] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites. (2007)
  • 著者名/発表者名: Ali. V. and Nozaki, T.
  • 雑誌名: Clin. Microbiol. Rev. 20 ページ: 164-187
  • 査読あり
• [雑誌論文] Structre and content of the Entamoeba histolytica genome. (2007)
  • 著者名/発表者名: Clark, C. G., Cecilia, U., Alsmark, M., Hofer, M., Saito-Nakano, Y., Ali, V., Marion, S., Weber, C., Mukherjee, C., Bruchhaus, I., Tannich, E., Leippe, M., Sicheritz-Ponten, T., Foster, P. G., Samuelson, J., Noel, C. J., Hirt, R. P., Embley, T. M., Glchrist, C.A., Mann, B. J., Singh, U., Ackers, J. P., Bhattacharya, S., Bhattacharya, A., Lohia. A., Guillen, N., Duchene, M., Nozaki, T., and Hall, N.
  • 雑誌名: Adv. Parasitol. 65 ページ: 51-190
  • 査読あり
• [雑誌論文] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites. (2007)
  • 著者名/発表者名: Ali.V., Nozaki, T.
  • 雑誌名: Clin.Microbiol.Rev. 20 ページ: 164-187
• [雑誌論文] Biochemical and functional characterization of phosphoserine aminotransferase from Entameba histolytica, which possesses both phosphorylated and non-phosphorylated serine metabolic pathways. (2006)
  • 著者名/発表者名: Ali, V. and Nozaki, T.
  • 雑誌名: Mol. Biochem. Parasitol. 巻: 145 ページ: 71-83
• [雑誌論文] Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome. (2006)
  • 著者名/発表者名: Gilchrist, C. A., Houpt, E., Trapaidze, N., Fei, Z., Crasta, O., Asgharpour, A., Evans, C., Martino-Catt, S., Baba, D. J., Stroup, S., Hamano, S., Ehrenkaufer, G., Okada, M., Singh, U., Nozaki, T., Mann, B. J., Petri, Jr., W.
  • 雑誌名: Mol. Biochem. Parasitol. 巻: 147 ページ: 163-176
• [雑誌論文] Expression, purification, and crystallization of L-methionine γ-lyase 2 from Entamoeba histolytica. Acta Crystallograph. (2006)
  • 著者名/発表者名: Sato, D., Yamagata, W., Kamei, K., Nozaki, T. and Harada, S.
  • 雑誌名: Sect. F Struct. Biol. Cryst. Commun. 巻: 62 ページ: 1034-1036
• [雑誌論文] Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome. (2006)
  • 著者名/発表者名: Gilchrist, C.A., Houpt, E., Trapaidze, N., Fei, Z., Crasta, O., Asgharpour, A., Evans, C., Martino-Catt, S., Baba, D.J., Stroup, S., Hamano, S., Ehrenkaufer, G., Okada, M., Singh, U., Nozaki, T., Mann, B.J., Petri, Jr., W.
  • 雑誌名: Mol. Biochem. Parasitol. 147 ページ: 163-176
• [雑誌論文] Expression, purification, and crystallization of L-methionine g-lyase 2 from Entamoeba histolytica. (2006)
  • 著者名/発表者名: Sato, Ti, Yamagata, W., Kamei, K., Nozaki, T. Harada, S.
  • 雑誌名: Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62 ページ: 1034-1036
• [雑誌論文] Impact of intestinal colonization and invasion on the Entamoebahistolytica transcriptome. (2006)
  • 著者名/発表者名: Gilchrist, C.A., Houpt, E., Trapaidze, N., Fei, Z., Crasta, O., Asgharpour, A., Evans, C., Martino-Catt, S., Baba, D.J., Stroup, S., Hamano, S., Ehrenkaufer, G., Okada, M., Singh, U., Nozaki, T., Mann, B.J., Petri, Jr., W.
  • 雑誌名: Mol.Biochem.Parasitol. 147 ページ: 163-176
• [雑誌論文] Expression, purification, and crystallization of L-methionine γ-lyase 2 from Entamoeba histolytica. (2006)
  • 著者名/発表者名: Sato, D., Yamagata, W., Kamei, K., Nozaki, T., Harada, S.
  • 雑誌名: Acta Crystallograph.Sect.F Struct.Biol.Cryst.Commun. 62 ページ: 1034-1036
• [学会発表] Mechanism of trifluoromethionine resistance in Entamoeba histolytica. (2011)
  • 著者名/発表者名: Penuliar, G. M., Furukawa, A., Sato, D., and Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] Entamoeba invadens : transcriptome analysis during encystation. (2011)
  • 著者名/発表者名: Escueta-de Cadiz, A., Nakada-Tsukui, K., Caler, E., and Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] Metabolomic analysis during differentiation of enteric protozoan parasite Entamoeba histolytica into the infectious cyst stage. (2011)
  • 著者名/発表者名: Jeelani, G., Sato, D., Husein, A., Suematsu, M., Soga, T., and Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] Gene silencing of mitosomal proteins causes growth inhibition and suggests essentiality of mitosomes in Entamoeba histolytica. (2011)
  • 著者名/発表者名: Mi-ichi, F, Yousuf, A., Makiuchi, T., Nakada-Tsukui, K., and Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] Metabolomic analysis of sulfur containing amino acid metabolism in E. histolytica. (2011)
  • 著者名/発表者名: Husain, A., Sato, D., Jeelani, G., Mi-ichi, F., Ali, V., Suematsu, M., Soga, T., and Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] Analysis of the protein import machinery in the Entamoeba mitochondrial remnant. (2011)
  • 著者名/発表者名: Makiuchi, T., Mi-ichi, F., Nakada-Tsukui, K., and Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] A novel class of hydrolase receptors involved in the lysosomal trafficking of virulence factors in Entamoeba histolytica. (2011)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: The Second Cross-Straits and Asia Pacific International Conference on Parasites(Invited lecture)
  • 発表場所: Tainan, Taiwan.
• [学会発表] A novel import machinery of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica. (2011)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: International Union of Microbiological Societies.(Symposist and Convenor)
  • 発表場所: Sapporo, Japan.
• [学会発表] Novel receptor family proteins mediate transport of lysosomal enzymes in the enteric protozoan parasite Entamoeba histolytica. (2011)
  • 著者名/発表者名: Nakada-Tsukui, K., Tsuboi, K., Furukawa, A., Yamada, Y., and Nozaki, T.
  • 学会等名: International Union of Microbiological Societies.(Symposist)
  • 発表場所: Sapporo, Japan.
• [学会発表] Trafficking mechanisms of phagosomal proteins in Entamoeba histolytica. (2011)
  • 著者名/発表者名: Furukawa, A., Nakada-Tsukui, K., and Nozaki, T.
  • 学会等名: International Union of Microbiological Societies.
  • 発表場所: Sapporo, Japan.
• [学会発表] Metabolomic analysis during differentiation of enteric protozoan Parasite Entamoeba histolytica into the infectious cyst stage (2011)
  • 著者名/発表者名: Jeelani, G., Sato, D., Husein, A., Suematsu, M., Soga, T., Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] Gene silencing of mitosomal proteins causes growth inhibition and suggests essentiality of mitosomes in Entamoeba histolytica (2011)
  • 著者名/発表者名: Mi-ichi, F, Yousuf, A., Makiuchi, T., Nakada-Tsukui, K., Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo, Japan
• [学会発表] Metabolomic analysis of sulfur containing amino acid metabolism in E.histolytica (2011)
  • 著者名/発表者名: Husain, A., Sato, D., Jeelani, G., Mi-ichi, F., Ali, V., Suematsu, M., Soga, T., Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo, Japan
• [学会発表] Analysis of the protein import machinery in the Entamoeba mitochondrial remnant (2011)
  • 著者名/発表者名: Makiuchi, T., Mi-ichi, F., Nakada-Tsukui, K., Nozaki, T.
  • 学会等名: The 45^<th> US-Japan Cooperative Medical Science Program
  • 発表場所: Tokyo, Japan
• [学会発表] A novel import machinery of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica (2011)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: International Union of Microbiological Societies
  • 発表場所: Sapporo, Japan
• [学会発表] Novel receptor family proteins mediate transport of lysosomal enzymes in the enteric protozoan parasite Entamoeba histolytica (2011)
  • 著者名/発表者名: Nakada-Tsukui, K., Tsuboi, K., Furukawa, A., Yamada, Y., Nozaki, T.
  • 学会等名: International Union of Microbiological Societies
  • 発表場所: Sapporo, Japan
• [学会発表] Function and transport of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica (2011)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: The 1st As i an Conference of Prosistology
  • 発表場所: Jeju, Korea
• [学会発表] A novel class of hydrolase receptors involved in the lysosomal trafficking of virulence factors in Entamoeba histolytica (2011)
  • 著者名/発表者名: Nozaki, T., Nakada-Tsukui, K., Furukawa, A.
  • 学会等名: The 1st Asian Conference of Prosistology
  • 発表場所: Jeju, Korea
• [学会発表] Mitosomes in the enteric protozoan parasite Entamoeba histolytica contain a sulfate activation pathway. (2010)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: Adaptive and Innate Immune Response to Neglected Tropical Diseases. US-Japan Cooperative Medical Science Program.
  • 発表場所: San Diego
• [学会発表] Metabolic analysis of the human enteric parasite Entamoeba histolytica : Discovery of unique pathways and potential targets for chemotherapeutics. (2010)
  • 著者名/発表者名: Sato, D., Husain, A., Jeelani, G., Suematsu, M., Soga, T., and Nozaki, T.
  • 学会等名: Metabolomics 2010
  • 発表場所: Amsterdam, The Netherlands
• [学会発表] Metabolomics of parasite differentiation : metabolomic profiling of the human enteric protozoan parasite Entamoeba histolyitca revealed activation of unpredicted pathways during differentiation of the proliferative into dormant stage. (2010)
  • 著者名/発表者名: Jeelani, G., Sato, D., Jusain, A., Suematsu, M., Soga, T., and Nozaki, T.
  • 学会等名: Metabolomics 2010
  • 発表場所: Amsterdam, The Netherlands
• [学会発表] Unprecedented role of the mitosome in Entamoba histolytica. (2010)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: The 18^<th> Meeting of the International Society for Evolutionary Protistology
  • 発表場所: Kanazawa, Japan
• [学会発表] Mitosomes from the enteric protozoan parasite Entamoeba histolytica possess unique functions and minimal import machinery. (2010)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: The XIIth International Congress of Parasitology.
  • 発表場所: Melbourne, Australia.
• [学会発表] Metabolomic analysis of Entamoeba : discovery of unique pathways and potential targets for chemotherapy. (2010)
  • 著者名/発表者名: Nozaki, T, Husain, A., Jeelni, G, Sato, D., Suematsu, M., and Soga, T.
  • 学会等名: Amebiasis Workshop 2010, "Molecular Approaches and Clinical Aspects"
  • 発表場所: Montreal.
• [学会発表] Mechanism of trifluoromethionine resistance in Entamoeba histolytica. (2010)
  • 著者名/発表者名: Penuliar, G. and Nozaki, T.
  • 学会等名: Amebiasis Workshop 2010, "Molecular Approaches and Clinical Aspects"
  • 発表場所: Montreal
• [学会発表] Entamoeba invadens : Transcriptome analysis during encystation. (2010)
  • 著者名/発表者名: Escueta-de Cadiz, A., Nakada-Tsukui, K., Caler, E., and Nozaki, T.
  • 学会等名: 21st Molecular Parasitology Meeting
  • 発表場所: WoodsHole, Massachusetts, USA.
• [学会発表] Analysis of the protein import machinery in the Entamoeba mitochondrial remnant. (2010)
  • 著者名/発表者名: Makiuchi, T., Mi-ichi, F., Nakada-Tsukui, K., and Nozaki, T.
  • 学会等名: Biology of Symbiosis: Memorial Symposiumfor the 26^<th> International Prize for Biology-Celebrating Dr. Nancy A. Moran.
  • 発表場所: Tsukuba, Japan.
• [学会発表] Metabolic analysis of the human enteric parasite Entamoeba histolytica : Discovery of unique pathways and potential targets for chemotherapeutics (2010)
  • 著者名/発表者名: Sato, D., Husain, A., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T.
  • 学会等名: Metabolomics 2010
  • 発表場所: Amsterdam, The Netherlands
• [学会発表] Metabolomics of parasite differentiation : metabolomic profiling of the human enteric protozoan parasite Entamoeba histolyitca revealed activation of unpredicted pathways during differentiation of the proliferative into dormant stage (2010)
  • 著者名/発表者名: Jeelani, G., Sato, D., Jusain, A., Suematsu, M., Soga, T., Nozaki, T.
  • 学会等名: Metabolomics 2010
  • 発表場所: Amsterdam, The Netherlands
• [学会発表] Unprecedented role of the mitosome in Entamoba histolytica (2010)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: The 18^<th> Meeting of the International Society for Evolutionary Protistology
  • 発表場所: Kanazawa, Japan
• [学会発表] Mitosomes from the enteric protozoan parasite Entamoeba histolytica possess unique functions and minimal import machinery (2010)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: The XIIth International Congeress of Parasitology
  • 発表場所: Melbourne Australia
• [学会発表] Metabolomic analysis of Entamoeba : discovery of unique pathways and potential targets for chemotherapy (2010)
  • 著者名/発表者名: Nozaki, T, Husain, A., Jeelni, G, Sato, D., Suematsu, M., Soga, T.
  • 学会等名: Amebiasis Workshop 2010, "Molecular Approaches and Clinical Aspects"
  • 発表場所: Montreal, Canada
• [学会発表] Mitosomes in the enteric protozoan parasite Entamoeba histolytica contain a sulfate activation pathway. Adaptive and Innate Immune Response to Neglected Tropical Diseases. (2010)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: US-Japan Cooperative Medical Science Program
  • 発表場所: San Diego
• [学会発表] Role of sulfur-containing amino acid metabolism : characterization of two isotypes of methionine gamma-lyase in Entamoeba histolytica. (2009)
  • 著者名/発表者名: Nozaki, T., Furukawa, A., Jeelani, G., Sato, D., Karaki, T., and Harada, S.
  • 学会等名: XVI Seminario Sobre Amibiasis and EMBO Workshop. Amoebiasis : Molecular Approaches in an Important but Neglected Disease.
  • 発表場所: Guanajuato, Mexico.
• [学会発表] Biochemical and physiological function of a novel reductase from the microaerophilic protozoan parasite Entamoeba histolytica. (2009)
  • 著者名/発表者名: Jeelani, G., Husain, A., Sato, D., Suematsu, M., Ali, V., and Nozaki, T.
  • 学会等名: The 9th Awaji International Forum on Infection and Immunity.
  • 発表場所: Awaji
• [学会発表] MEtabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in enteric protozoan parasite Entamoeba histolytica. (2009)
  • 著者名/発表者名: Husain, A., Jeelani, G., Sato, D., Mi-ichi, F., Soga, T., Suematsu, M., Ali, V., and Nozaki, T.
  • 学会等名: The 9th Awaji International Forum on Infection and Immunity.
  • 発表場所: Awaji
• [学会発表] Rab small GTPases and phosphatidylinositides regulate phagocytosis and membrane trafficking of virulence factors : their roles in the pathogenesis of amebiasis. (2009)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: XVIIIth Congress of Parasitology
  • 発表場所: Aguascalientes, Mexico
• [学会発表] 赤痢アメーバ症新規創薬 (2009)
  • 著者名/発表者名: 野崎智義
  • 学会等名: 第147回日本獣医学会学術集会
  • 発表場所: 宇都宮
• [学会発表] ミトコンドリア関連オルガネラの新規機能-赤痢アメーバ原虫"sulfosome"に存在する硫酸活性化経路 (2009)
  • 著者名/発表者名: 見市文香、野崎智義
  • 学会等名: 第82回日本生化学会大会
  • 発表場所: 神戸
• [学会発表] Entamoeba histolytica由来メチオニンガンマリアーゼ1と2のX線結晶構造解析 (2009)
  • 著者名/発表者名: 唐木剛、村野祥子、亀井加恵子、佐藤暖、野崎智義、原田繁春
  • 学会等名: 第82回日本生化学会大会
  • 発表場所: 神戸
• [学会発表] 腸管寄生性原虫赤痢アメーバにおける酸化ストレス応答のメタボローム解析 (2009)
  • 著者名/発表者名: 野崎智義
  • 学会等名: 第4回メタボロームシンポジウム
  • 発表場所: 横浜
• [学会発表] 真核生物におけるミトコンドリアの多様性:腸管寄生原虫赤痢アメーバの新規オルガネラの解析 (2009)
  • 著者名/発表者名: 野崎智義
  • 学会等名: 第9回日本ミトコンドリア学会年会
  • 発表場所: 東京
• [学会発表] Role of sulfur-containing amino acid metabolism: characterization of two isotypes of methionine gamma-lyase in Entamooba histolytica. (2009)
  • 著者名/発表者名: Nozaki, T., Furukawa, A., Jeelani, G., Sato, D., Karaki, T., Harada, S.
  • 学会等名: XVI Seminario Sobre Amibiasis and EMBO Workshop. Amoebiasis: Molecular Approaches in an Important but Neglected Disease.
  • 発表場所: Guanajuato, Mexico.
• [学会発表] Role of sulfur-containing amino acid metabolism : characterization of two isotypes of methionine gamma-lyase in Entamoaha histnlytica. (2009)
  • 著者名/発表者名: Nozaki, T., Furukawa, A., Jeelani, G., Sato, D., Karaki, T., and Harada, S.
  • 学会等名: XVI Seminario Sobre Amibiasis and EMBO Workshop. Amoebiasis : Molecular Approaches in an Important but Neglected Disease.
  • 発表場所: Guanajuato, Mexico.
• [学会発表] The mitosome in Entamoeba histolytica. (2008)
  • 著者名/発表者名: Miichi, F., Abu, Y. M., Nakada-Tsukui, K., and Nozaki, T.
  • 学会等名: US-Japan Cooperative Science Program.
  • 発表場所: Davis, USA.
• [学会発表] Kinetic characterizationof methionine gamma-lyase from Entamoeba histolytica against physiological substrates and trifluoromethionine. (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Karaki, T., Harada, S., and Nozaki, T.
  • 学会等名: The 4th International Conference on Anaerobic Protists: The Systems Biology of Anaerobic Protozoa.
  • 発表場所: Taipei, Taiwan.
• [学会発表] Metabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolytica. (2008)
  • 著者名/発表者名: Husein, A., Jeelani, G., Bilal, A. S., Sato, D., Mi-ichi, F., Hishiki, T., Gilchrist, C. A., Suematsu, M., Petri, Jr., W. A., and Nozaki, T.
  • 学会等名: The 8th Awaji International Forum on Infection and Immunity.
  • 発表場所: Awaji
• [学会発表] Characterization of methionine gamma-lyases from enteric protozoan parasite, Entamoeba histolytica, as a potential drug target against amoebiasis". (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Karaki, T., Shimizu, A., Harada, S., and Nozaki, T.
  • 学会等名: The 8th Awaji International Forum on Infection and Immunity.
  • 発表場所: Awaji
• [学会発表] Regulation of cysteine protease secretion and phagocytosis in Entamoeba histolytica. (2008)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: XVIIth International Congress for Tropical Medicine and Malaria (Invited talk in the symposium).
  • 発表場所: Jeju, Korea
• [学会発表] The mitochondria-related organelle in the anaerobic parasitic protozoon Entamoeba histolytica. (2008)
  • 著者名/発表者名: Mi-ichi, F., Abu, Y. M., Nakada-Tsukui, K., Kawai, S., and Nozaki, T.
  • 学会等名: International Symposium on Protistology: Evolution and Diversity.
  • 発表場所: Tsukuba, Japan
• [学会発表] The mitochondria-related organelle in the anaerobic protist Entamoeba histolytica. (2008)
  • 著者名/発表者名: Mi-ichi, F., Abu, Y. M., Nakada-Tsukui, K., Kawai, S., and Nozaki, T.
  • 学会等名: International Symposium: Bacteria made ornangelles made eukaryotic cells.
  • 発表場所: Tokyo, Japan
• [学会発表] 痢アメーバEntamoeba histolytica由来メチオニンγ-リアーゼのX線結晶構造解析 (2008)
  • 著者名/発表者名: 清水顕、唐木剛、佐藤暖、亀井加恵子、野崎智義、原田繁春
  • 学会等名: 第8回日本蛋白質科学会年会
  • 発表場所: 東京
• [学会発表] 腸管寄生性アメーバ原虫のメチオニンγ-リアーゼと薬剤リード化合物の反応機構の解明 (2008)
  • 著者名/発表者名: 佐藤暖、山形渉、唐木剛、原田繁春、野崎智義
  • 学会等名: 日本ビタミン学会第60回大会
  • 発表場所: 仙台
• [学会発表] Characterization of methionine gamma-lyases from enteric protozoan parasite, Entamoeba histolytica, as a potential drug target against amoebiasis (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Karaki, T., Shimizu, A., Harada, S., Nozaki, T.
  • 学会等名: The 8th Awaji International Forum on Infection and Immunity.
  • 発表場所: Awaji
• [学会発表] 寄生性原虫の含硫アミノ酸代謝の重要性-メタボローム解析からのアプローチ (2008)
  • 著者名/発表者名: 佐藤暖、Afzal Husain, 曽我朋義、末松誠、野崎智義
  • 学会等名: 第3回メタボロームシンポジウムーメタボロミクスが解き明かす生命のシステム
• [学会発表] 含硫アミノ酸分解酵素・メチオニンγ-リアーゼを標的とした新規抗赤痢アメーバ薬の開発 (2008)
  • 著者名/発表者名: 佐藤暖、唐木剛、原田繁春、柴田哲男、融健、野崎智義
  • 学会等名: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • 発表場所: 神戸
• [学会発表] 硫黄含有アミノ酸生合成・分解経路を標的とする抗赤痢アメーバ薬の開発-メチオニンγリアーゼの立体構造と阻害剤の結合様式- (2008)
  • 著者名/発表者名: 唐木剛、清水顕、佐藤暖、亀井加恵子、原田繁春、野崎智義
  • 学会等名: 第7回分子寄生虫・マラリア研究フォーラム
  • 発表場所: 松山
• [学会発表] Kinetic characterization of methionine gamma-lyase from Entamoeba histolytica against physiological substrates and trifluoromethionine. (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Karaki, T., Harada, S., and Nozaki, T.
  • 学会等名: The 4th International Conference on Anaerobic Protists : The Systems Biology of Anaerobic Protozoa.
  • 発表場所: Taipei, Taiwan
• [学会発表] 赤痢アメーバEntamoeba histolytica由来メチオニンγ-リアーゼのX線結晶構造解析、 (2008)
  • 著者名/発表者名: 清水顕, 唐木剛, 佐藤暖, 亀井加恵子, 野崎智義, 原田繁春
  • 学会等名: 第8回日本蛋白質科学会年会、
  • 発表場所: 東京
• [学会発表] 腸管寄生性アメーバ原虫のメチオニンγ-リアーゼと薬剤リード化合物の反応機構の解明、 (2008)
  • 著者名/発表者名: 佐藤暖, 山形渉, 唐木剛, 原田繁春, 野崎智義
  • 学会等名: 日本ビタミン学会第60回大会
  • 発表場所: 仙台
• [学会発表] Metabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolytica.. (2008)
  • 著者名/発表者名: Husein, A., Jeelani, G., Bilal, A. S., Sato, D., Mi-ichi, F., Hishiki, T., Gilchrist, C. A., Suematsu, M., Petri, Jr., W. A., and Nozaki, T
  • 学会等名: The 8th Awaji International Forum on Infection and Immunity. Awaji
  • 発表場所: Awaji, Japan
• [学会発表] Characterization of methionine gamma-lyases from enteric protozoan parasite, Entamoeba histolytica, as a potential drug taraet against amoebiasis. (2008)
  • 著者名/発表者名: Sato, D., Yamagata, W., Karaki, T., Shimizu, A., Harada, S., and Nozaki, T.
  • 学会等名: The 8th Awaji International Forum on Infection and Immunity.,
  • 発表場所: Awaji, Japan
• [学会発表] 寄生性原虫の含硫アミノ酸代謝の重要性-メタボローム解析からのアプローチ (2008)
  • 著者名/発表者名: 佐藤暖, Afzal Husain, 曽我朋義, 末松誠, 野崎智義
  • 学会等名: 第3回メタボロームシンポジウム-メタボロミクスが解き明かす生命のシステム-
  • 発表場所: 鶴岡市
• [学会発表] 含硫アミノ酵分解酵素・メチオニンγ-リアーゼを標的とした新規抗赤痢アメーバ薬の開発 (2008)
  • 著者名/発表者名: 佐藤暖, 唐木剛, 原田繁春, 柴田哲男, 融健, 野崎智義
  • 学会等名: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • 発表場所: 神戸
• [学会発表] Regulation and physiological importance of sulfur-containing amino acid metabolism in Entamoeba histolytica. (2007)
  • 著者名/発表者名: Ali, V. and Nozaki, T.
  • 学会等名: 41st Joint Conference on Parasitic Diseases of The Japa-United States Cooperative Medical Science Program
  • 発表場所: Tokyo
• [学会発表] Regulation of secretion of cysteine proteases by Rab11B small GTPase and proteinous inhibitors in Entamoeba histolytica. (2007)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: 5th European Congress on Tropical Medicine and International Health
  • 発表場所: Amsterdam, the Netherlands
• [学会発表] Characterization of cysteine biosynthetic pathway: a potential drug target in Entamoeba histolyitca. (2007)
  • 著者名/発表者名: Ali, V., Husain, A., and Nozaki, T.
  • 学会等名: The 7th International Forum on Infection and Immunity
  • 発表場所: Awaji, Hyogo, Japan
• [学会発表] Characterization and evaluating the rol of serine O-acetyltransferase isoforms in cysteine biosynthetic pathway in Entamoeba histolyitca. (2007)
  • 著者名/発表者名: Hussain, S., Ali, V., and Nozaki, T.
  • 学会等名: The 7th International Forum on Infection and Immunity
  • 発表場所: Awaji, Hyogo, Japan
• [学会発表] Metabolic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolyitca. (2007)
  • 著者名/発表者名: Husain, A., Hishiki, T., Gilchrist, C. A., Ali, V., Suematsu, M., Petri, Jr., W. A., and Nozaki, T.
  • 学会等名: The 7th International Forum on Infection and Immunity
  • 発表場所: Awaji, Hyogo
• [学会発表] Autophagy in Entamoeba. (2007)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: 13^<th> Forum Cheju Korea-Japan Parasitology Seminar
  • 発表場所: Chuncheon, Korea.
• [学会発表] Proteomic analysis of the virulence of the enteric protozoan parasite Entamoeba histolyitca. (2007)
  • 著者名/発表者名: Nozaki, T.
  • 学会等名: The 2^<nd> Mexican Symposium of Cellular and Molecular Proteomics of Mass Spectrometry
  • 発表場所: Guanajuato, Mexico
• [学会発表] Unique characteristics of pyridine nucleotide transhydrogenase in Entamoeba histolyitca. (2007)
  • 著者名/発表者名: Yousuf, M.A., Nakada-Tsukui, K., and Nozaki, T.
  • 学会等名: International Symposium on Membrane Traffic
  • 発表場所: Awaji, Hyogo, Japan.
• [学会発表] Iron sulfur (Fe-S) cluster assembly in the enteric protozoan parasite Entamoeba histolytica: localization, oxygen sensitivity, and physiological significance. (2006)
  • 著者名/発表者名: Ali, V. and Nozaki, T.
  • 学会等名: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • 発表場所: Kyoto
• [学会発表] Cysteine biosynthesis pathway in Entamoeba histolytica is a rational target to develop new chemotherapeutics against amebiasis. (2006)
  • 著者名/発表者名: Ali, V. and Nozaki, T.
  • 学会等名: The 6th Awaji International Forum on Infection and Immunity
  • 発表場所: Awaji, Hyogo, Japan
• [備考]
  • URL: http://www.nih.go.jp/niid/para/parasite.html
• [備考]
  • URL: http://www.nih.go.jp/niid/ja/2011-05-26-00-03-52.html
• [備考]
  • URL: http://www.nih.go.jp/niid/para/parasite.html
• [備考]
  • URL: http://parasite.dept.med.gunma-u.ac.jp/Enozaki_lab.html
• [備考]
  • URL: http://parasite.dept.med.gunma-u.ac.jp/Enozaki_lab.html