単純ヘルペスウイルスの増殖と病原性発現の分子基盤

• 研究領域: 感染現象のマトリックス
• 研究課題/領域番号: 18073007
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 名古屋大学
• 研究代表者: 西山 幸廣 名古屋大学, 医学系研究科, 教授 (60115615)
• 研究期間 (年度): 2006 – 2010
• 研究課題ステータス: 完了 (2010年度)
• 配分額: 94,000千円 (直接経費: 94,000千円); 2010年度: 18,800千円 (直接経費: 18,800千円); 2009年度: 18,800千円 (直接経費: 18,800千円); 2008年度: 18,800千円 (直接経費: 18,800千円); 2007年度: 18,800千円 (直接経費: 18,800千円); 2006年度: 18,800千円 (直接経費: 18,800千円)
• キーワード: 単純ヘルペスウイルス / DNAウイルス / ウイルス遺伝子機能 / ウイルス病原性 / ウイルス増殖機構

研究概要

ヒトの病原体として重要な単純ヘルペスウイルスの増殖機構、病原性発現機構を明らかにするため、ウイルスの保有する遺伝子産物の機能解析を行い、それらがアポトーシス制御、蛋白質分解系制御、細胞内輸送系制御に関わっていることを明らかにした。また、細胞因子としてINSM1、Tankylase1がウイルス増殖に関与していることを示した。これらの基礎研究はワクチンや腫瘍溶解性ウイルスの開発に有用であった。

研究成果

• [雑誌論文] Mitochondria and viruses. (2011)
  • 著者名/発表者名: Ohta A, Nishiyama Y.
  • 雑誌名: Mitochondrion. 11(1) ページ: 1-12
  • 査読あり
• [雑誌論文] Auditory and Vestibular Defects Induced by Experimental Labyrinthitis Following Herpes Simplex Virus in Mice (2011)
  • 著者名/発表者名: Esaki S, Goshima F, et.al.
  • 雑誌名: Acta Otolarygologica. 巻: (印刷中 未定)
  • 査読あり
• [雑誌論文] Mitochondria and viruses. (2011)
  • 著者名/発表者名: Ohta, A., Nishiyama, Y.
  • 雑誌名: Mitochondrion 巻: 11 ページ: 1-12
  • 査読あり
• [雑誌論文] Apoptosis induction after herpes simplex virus infection differs according to cell type in vivo. (2010)
  • 著者名/発表者名: Esaki, S., Goshima, F., Katsumi, S., Watanabe, D., Ozaki, N., Murakami, S., Nishiyama, Y.
  • 雑誌名: Archieves of Virology 155 ページ: 1235-1245
  • 査読あり
• [雑誌論文] Carrier cell-based delivery of replication- competent HSV-1 mutants enhances antitumor effect for ovarian cancer. (2010)
  • 著者名/発表者名: Fujiwara, S., Nawa, A., Luo, CH., Kamakura, M., Goshima, F., Kondo, C., Kiyono, T., Kikkawa, F., Nishiyama, Y.
  • 雑誌名: Cancer Gene Therapy 18 ページ: 77-86
  • 査読あり
• [雑誌論文] Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch. (2010)
  • 著者名/発表者名: Ushijima Y, Luo C, Kamakura M, Goshima F, Kimura H, Nishiyama Y.
  • 雑誌名: Virology Journal. 7(1) ページ: 179-179
  • 査読あり
• [雑誌論文] A phase 1 dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer. (2010)
  • 著者名/発表者名: Nakao, A., Kasuya, H., Sahin, TT, et.al.
  • 雑誌名: Cancer Gene Therapy 巻: (In press 未定)
  • 査読あり
• [雑誌論文] Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch. (2010)
  • 著者名/発表者名: Ushijima Y, Luo C, Kamakura M, et.al.
  • 雑誌名: Virology Journal. 巻: 7 ページ: 179-179
  • 査読あり
• [雑誌論文] Carrier cell-based delivery of replication- competent HSV-1 mutants enhances antitumor effect for ovarian cancer. (2010)
  • 著者名/発表者名: Fujiwara, S., Nawa, A., Luo, CH., et al.
  • 雑誌名: Cancer Gene Therapy 巻: 18 ページ: 77-86
  • 査読あり
• [雑誌論文] Apoptosis induction after herpes simplex virus infection differsaccording to cell type in vivo. (2010)
  • 著者名/発表者名: Esaki, S., Goshima, F., Katsumi, S., et.al.
  • 雑誌名: Archieves of Virology 巻: 155 ページ: 1235-1245
  • 査読あり
• [雑誌論文] Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection. (2010)
  • 著者名/発表者名: Iwata, S., Wada, K., Tobita, S., et. al.
  • 雑誌名: Journal of General Virology 91 ページ: 42-50
  • 査読あり
• [雑誌論文] Enhanced cytotoxicity with a novel system combining the paclitaxel-2'-ethylcarbonate produrug and an HSV amplicon with attenuated replication-cmmpetent vints, HF10 as a helper virus. (2010)
  • 著者名/発表者名: Ishida, D., Nawa, A., Tanino, T., et. al.
  • 雑誌名: Cancer Letters (in press)
  • 査読あり
• [雑誌論文] Multiplex real-time PCR assay for quantifying BK polyomavirus, JC polyomavirus, and adenovirus DNA simultaneously. (2010)
  • 著者名/発表者名: Funahashi, Y., Iwata, S., Ito, Y., et. al.
  • 雑誌名: Journal of Clinical Microbiology (in press)
  • 査読あり
• [雑誌論文] Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex. (2009)
  • 著者名/発表者名: Sato, Y., Kamura, T., Shirata, N., Murata, T., Kudoh, A., Iwahori, S., Nakayama, S., Isomura, H., Nishiyama, Y., Tsurumi, T.
  • 雑誌名: PLoS Pathogens 7
  • 査読あり
• [雑誌論文] Herpes simplex viruuuumplex virux viruex viru viru viruegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions. (2009)
  • 著者名/発表者名: Ushijima, Y., Goshima, F., Kimura, H., Nishiyama, Y.
  • 雑誌名: Virology Journal 6 ページ: 168-168
  • 査読あり
• [雑誌論文] Differences in the regulatory and functional effects of the US3 protein kinase activities of herpes simplex virus 1 and 2. (2009)
  • 著者名/発表者名: Morimoto, T., Arii, J., Tanaka, M., Sata, T., Akashi, H., Yamada, M., Nishiyama, Y., Uema, M., Kawaguchi, Y.
  • 雑誌名: Journal of Virology 83 ページ: 11624-11634
  • 査読あり
• [雑誌論文] Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice. (2009)
  • 著者名/発表者名: Ishikawa, T., Yamada, H., Oyamada, A., Goshima, F., Nishiyama, Y., Yoshikai, Y.
  • 雑誌名: Journal of Virology 83 ページ: 11777-11783
  • 査読あり
• [雑誌論文] Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription. (2009)
  • 著者名/発表者名: Sato Y, Shirata N, Kudoh A, et. al.
  • 雑誌名: Virology 388 ページ: 204-211
  • 査読あり
• [雑誌論文] Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. (2009)
  • 著者名/発表者名: Mizuno T, Sugiura S, Kimura H, et. al.
  • 雑誌名: Eur Arch Otorhinolaryngol 266 ページ: 351-355
  • 査読あり
• [雑誌論文] Multiplex real-time PCR for the simultaneous detection of herpes simplexvirus, human herpesvirus 6, and human herpesvirus 7. (2009)
  • 著者名/発表者名: Wada K, Mizoguchi S, Ito Y, et. al.
  • 雑誌名: Microbiol Immunol 53 ページ: 22-29
  • 査読あり
• [雑誌論文] Degradation of Phosphorylated p53 by Viral Protein-ECS E3 Ligase Complex. (2009)
  • 著者名/発表者名: Sato Y, Kamura T, Shirata N, et. al.
  • 雑誌名: PLoS Pathog 5
  • 査読あり
• [雑誌論文] Identification of Epstein-Barr Virus (EBV)-Infected Lymphocyte Subtypes by How Cytometric In Situ Hybridization in EBV-Associated Lymphoproliferative Diseases. (2009)
  • 著者名/発表者名: Kimura H, Miyake K, Yamauchi Y, et. al.
  • 雑誌名: J Infect Dis 200 ページ: 1078-1087
  • 査読あり
• [雑誌論文] A protective role of Fas-FasL signaling in lethal infection with herpes simplexvirus type 2 in mice. (2009)
  • 著者名/発表者名: Ishikawa T, Yamada H, Oyamada A, et. al.
  • 雑誌名: J Virol 83 ページ: 11777-11783
  • 査読あり
• [雑誌論文] Differences in the regulatory and functional effects of the US3 protein kinaseactivities of herpes simplex virus 1 and 2. (2009)
  • 著者名/発表者名: Morimoto, T., Arii, J., Tanaka, M., et al.
  • 雑誌名: Journal of Virology 83 ページ: 11624-11634
  • 査読あり
• [雑誌論文] Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions. (2009)
  • 著者名/発表者名: Ushijima, Y., Goshima, F., Kimura, H., et. al.
  • 雑誌名: Virology Journal 6 ページ: 168-168
  • 査読あり
• [雑誌論文] Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss (2009)
  • 著者名/発表者名: Mizuno T, Sugiura S, Kimura H, et.al.
  • 雑誌名: Eur Arch Otorhinolaryngol 266 ページ: 351-355
  • 査読あり
• [雑誌論文] A regulatory role of interleukin 15 in wound healing and mucosal infection in mice. (2008)
  • 著者名/発表者名: Kagimoto, Y., Yamada, H., Ishikawa, T., Maeda, N., Goshima, F., Nishiyama, Y., Furue, M., Yoshikai, Y.
  • 雑誌名: Journal of Leukocyte Biology 83 ページ: 165-172
  • 査読あり
• [雑誌論文] The UL14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1) is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids. (2008)
  • 著者名/発表者名: Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama Y.
  • 雑誌名: Journal of Virology 82 ページ: 1094-1106
  • 査読あり
• [雑誌論文] Microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their US3-deficient mutants (2008)
  • 著者名/発表者名: Kamakura, M., Nawa, A., Ushijima, Y., Goshima, F., Kawaguchi, Y., Kikkawa, F., Nishiyama, Y.
  • 雑誌名: Microbes and Infection 10 ページ: 405-413
  • 査読あり
• [雑誌論文] Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin Ligase Nedd4 and Increases its Ubiquitination. (2008)
  • 著者名/発表者名: Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y.
  • 雑誌名: Journal of Virology 82 ページ: 5220-5233
  • 査読あり
• [雑誌論文] Herpes Simplex Virus Induces Extensive Modification and Dynamic Relocalisation of the Nuclear Mitotic Apparatus Protein (NuMA) in Interphase Cells (2008)
  • 著者名/発表者名: Yamauchi, Y., Kiriyama, K., Kimura, H., Nishiyama, Y.
  • 雑誌名: Journal of Cell Science 121 ページ: 2087-2096
  • 査読あり
• [雑誌論文] Identification of a physiological phosphorylation site of the Herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells. (2008)
  • 著者名/発表者名: Kato, A., Tanaka, M., Yamamoto, M., Asai, R., Sata, T., Nishiyama, Y., Kawaguchi, Y.
  • 雑誌名: Journal of Virology 82 ページ: 6172-6189
  • 査読あり
• [雑誌論文] Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10 : applications for cancer gene therapy. (2008)
  • 著者名/発表者名: Nawa A, Luo C, Zhang L, Ushjima Y, Ishida D, Kamakura M, Fujimoto Y, Goshima F, Kikkawa F, Nishiyama Y.
  • 雑誌名: Curr Gene Therapy 8 ページ: 208-221
  • 査読あり
• [雑誌論文] Herpes simplex virus induces extensive modification and dynamic relocalisation of the nuclear mitotic apparatus protein (NuMA) in interphase cells (2008)
  • 著者名/発表者名: Yamauchi, Y., Kiriyama, K., Kimura, H. and Nishiyama, Y.
  • 雑誌名: Journal of Cell Science 121 ページ: 2087-2096
  • 査読あり
• [雑誌論文] Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase nedd4 and increases its ubiquitination. (2008)
  • 著者名/発表者名: Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y.
  • 雑誌名: Journal of Virology 82 ページ: 5220-5233
  • 査読あり
• [雑誌論文] The UL14 tegument protein of herpes simplex virus type 1 (HSV-1) is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids. (2008)
  • 著者名/発表者名: Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama Y.
  • 雑誌名: Journal of Virology 82 ページ: 1094-1106
  • 査読あり
• [雑誌論文] A regulatory role of interleukin 15 in wound healing and mucosal infection in mice (2008)
  • 著者名/発表者名: Kagimoto, T., Yamada, H., Ishikawa, T., et.al.
  • 雑誌名: Journal of Leukocyte Biology 83 ページ: 165-172
  • 査読あり
• [雑誌論文] One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection (2008)
  • 著者名/発表者名: Kubota, N., Wada, K., Ito, Y., et.al.
  • 雑誌名: Journal of Virological Methods 147 ページ: 26-36
  • 査読あり
• [雑誌論文] The UL 14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1) is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP 16 and Viral Capsids (2008)
  • 著者名/発表者名: Yamauchi Y, Kiriyama K, Kubota N, et.al.
  • 雑誌名: Journal of Virology 82 ページ: 1094-1106
  • 査読あり
• [雑誌論文] Gene directed enzyme prodrug therapy for ovarian cancer.-Could GDPET become a promising treatment against ovarian cancer (2008)
  • 著者名/発表者名: Nawa, A., Tanino, T., Luo, C., et.al.
  • 雑誌名: Anti-Cancer Agents in Medical Chemisyry 8 ページ: 232-239
  • 査読あり
• [雑誌論文] Microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their US 3-deficient mutants (2008)
  • 著者名/発表者名: Kamakura, M., Nawa, A., Ushijima, Y, et.al.
  • 雑誌名: Microbes and Infection 10 ページ: 405-413
  • 査読あり
• [雑誌論文] Oncolytic viral therapy for malignant melanoma with herpes simplex virus type 1 mutant HF 10 (2008)
  • 著者名/発表者名: Watanabe, D., Goshima, F., Mori, I., et.al.
  • 雑誌名: Journal of Dermatological Science 10 ページ: 185-196
  • 査読あり
• [雑誌論文] Herpes Simplex Virus Type 2 UL 56 Interacts with the Ubiquitin Ligase Nedd 4 and Increases its Ubiquitination (2008)
  • 著者名/発表者名: Ushijima Y, Koshizuka T, Goshima F, et.al.
  • 雑誌名: Journal of Virology 82 ページ: 5220-5223
  • 査読あり
• [雑誌論文] Herpes Simplex Virus Induces Extensive Modification and Dynamic Relocalisation of the Nuclear Mitotic Apparatus Protein (NuMA) in Interphase Cells (2008)
  • 著者名/発表者名: Yamauchi, Y., Kiriyama, K., Kimura, H. and Nishiyama, Y.
  • 雑誌名: Journal of Cell Science 121 ページ: 2087-2096
  • 査読あり
• [雑誌論文] Identification of a physiological phosphorylation site of the Herpes simplex virus 1-encoded protein kinase Us 3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells (2008)
  • 著者名/発表者名: Kato, A., Tanaka, M., Yamamoto, M., et.al.
  • 雑誌名: Journal of Virology 82 ページ: 6172-6189
  • 査読あり
• [雑誌論文] Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10 : applications for cancer gene therapy (2008)
  • 著者名/発表者名: Nawa A, Luo C, Zhang L, et.al.
  • 雑誌名: Curr Gene Therapy 8 ページ: 208-221
  • 査読あり
• [雑誌論文] Measuring Epstein-Barr virus (EBV) load : the significance and applic ation for each EBV-associated disease (2008)
  • 著者名/発表者名: Kimura H, Ito Y, Suzuki R, Ni shivama Y.
  • 雑誌名: Reviews in Medical Virology 18 ページ: 305-319
  • 査読あり
• [雑誌論文] Conversion from mycophenolate mofetil to mizoribine for patients with positive polyomavirus type BK in urine (2008)
  • 著者名/発表者名: Funahashi Y, Hattori R, Kinukawa T, et.al.
  • 雑誌名: Transplant Proc 40 ページ: 2268-2270
  • 査読あり
• [雑誌論文] The UL14 Tegument Protein of Herpes Simplex Virus Type 1(HSV-1)is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids. (2008)
  • 著者名/発表者名: Yamauchi Y, Kiriyama K, Kubota N, et. al.
  • 雑誌名: Journal of Virology 82 ページ: 1094-1106
  • 査読あり
• [雑誌論文] A regulatory role of interleukin 15 in wound healing and mucosal in 1. (2008)
  • 著者名/発表者名: Kagimoto, T., Yamada, H., Ishikawa, T., et. al.
  • 雑誌名: Journal of Leukocyte Biology 83 ページ: 166-172
  • 査読あり
• [雑誌論文] Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide. (2007)
  • 著者名/発表者名: Luo, C., Nawa, A., Yamauchi, Y., Kohno, S., Ushijima, Y., Goshima, F., Nishiyama, Y.
  • 雑誌名: Virus Genes 34 ページ: 263-272
  • 査読あり
• [雑誌論文] Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. (2007)
  • 著者名/発表者名: Ushijima Y, Luo C, Goshima F, Yamauchi Y, Kimura H, Nishiyama Y.
  • 雑誌名: Microbes and Infection 9(2) ページ: 142-149
  • 査読あり
• [雑誌論文] Suitability of a US3-inactivated HSV mutant(L1BR1) as an oncolytic-virus for pancreatic cancer therpay. (2007)
  • 著者名/発表者名: Kasuya, H., Nishiyama, Y., Nomoto, S., Goshima, F., Takeda, S., Watanabe, I., Nomura, N., Shikano, T., Fujii, T., Kanazumi, N., Nakao, A.
  • 雑誌名: Cancer Gene Therapy 14 ページ: 533-542
  • 査読あり
• [雑誌論文] Oncolytic Virotherapy with an HSV amplicon vector expressing granulocyte-macrophage colony-stimulating factor using the replication-competent HSV type I mutant HF10 as a helper (2007)
  • 著者名/発表者名: Kohno, S., Luo, C., Nawa, A., Fujimoto, Y., Waranabe, D., Goshima, F., Tsurumi, T., Nishiyama, Y.
  • 雑誌名: Cancer Gene Therapy 14 ページ: 918-926
  • 査読あり
• [雑誌論文] Herpes simplex virus protein UL11 but not UL51 is associated with lipid rafts. (2007)
  • 著者名/発表者名: Koshizuka, T., Kawaguchi, Y., Nozawa, N., Mori, I., Nishiyama, Y.
  • 雑誌名: Virus Genes 35 ページ: 571-575
  • 査読あり
• [雑誌論文] Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment. (2007)
  • 著者名/発表者名: Luo, C., Mori, I., Goshima, F., Ushijima, Y., Nawa, A., Kimura, H., Nishiyama, Y.
  • 雑誌名: Journal of Gene Medicine 9 ページ: 875-883
  • 査読あり
• [雑誌論文] Oncolytic virotherapy with an HSV amplicon vector expressing granulocyte-macrophage colony-stimulating factor using the replication-competent HSV type I mutant HF10 as a helper. (2007)
  • 著者名/発表者名: Kohno, S., Luo, C., Nawa, A., Fujimoto, Y., Waranabe, D., Goshima, F., Tsurumi, T. and Nishiyama, Y.
  • 雑誌名: Cancer Gene Therapy 14 ページ: 918-926
  • 査読あり
• [雑誌論文] Suitability of a US3-inactivated HSV mutant(L1BR1) as an oncolytic-virus for pancreatic cancer therpay. (2007)
  • 著者名/発表者名: Kasuya, H.,Nishiyama, Y., Nomoto, S., Goshima, F., Takeda, S., Watanabe, I., Nomura, N., Shikano, T., Fujii, T., Kanazumi, N. and Nakao, A.
  • 雑誌名: Cancer Gene Therapy 14 ページ: 533-542
  • 査読あり
• [雑誌論文] Herpes simplex virus protein UL11 but not UL51 is associated with lipid rafts. (2007)
  • 著者名/発表者名: Koshizuka, T., Kawaguchi, Y., Nozawa, N., et. al.
  • 雑誌名: Virus Genes 35 ページ: 571-575
  • 査読あり
• [雑誌論文] Simultaneous quantification of Epstein-Barr virus, Cytomegalovirus, and human Herpesvirus 6 DNA in transplant recipients by multiplex real-time PCR assay. (2007)
  • 著者名/発表者名: Wada, K., Kubota, N., Ito, Y., et. al.
  • 雑誌名: Journal of Clinical Microbiology 45 ページ: 1426-1432
  • 査読あり
• [雑誌論文] Oncolytic Virotherapy with an HSV amplicon vector expressing granulocyte-macrophage colony-stimulating factor using the replication-competent HSV type I mutant HF10 as a helper (2007)
  • 著者名/発表者名: Kohno, S., Luo, C., Nawa, A., et. al.
  • 雑誌名: Cancer Gene Therapy 14 ページ: 918-926
  • 査読あり
• [雑誌論文] Replication-competent, oncolytic herpes simplex virus type 1 mutants induce abystander effect following ganciclovir treatment. (2007)
  • 著者名/発表者名: Luo, C., Mori, I., Goshima, F., et. al.
  • 雑誌名: Journal of Gene Medicine 6 ページ: 875-883
  • 査読あり
• [雑誌論文] Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. (2007)
  • 著者名/発表者名: Ushijima Y, Luo C, Goshima F, et al.
  • 雑誌名: Microbes and Infection 9 ページ: 142-149
• [雑誌論文] Beneficial Effect of GB Virus C Co-Infection in Human Immunodeficiency Virus Type 1-Infected Individuals. (2007)
  • 著者名/発表者名: Hattori J, Okumura N, Yamazaki Y, et al.
  • 雑誌名: Microbiology and Immunology 51 ページ: 193-200
• [雑誌論文] Paclitaxel-2'-ethylcarbonate prodrug can overcome P-glycoprotein-mediated multidrug resistance to increase drug cytotoxicity. (2007)
  • 著者名/発表者名: Tanino T, Nawa A, Kondo, E, et al.
  • 雑誌名: Pharmaceertical Research (in press)
• [雑誌論文] Replication-competent herpes simplex virus : a novel and promising modality for cancer therapy. (2007)
  • 著者名/発表者名: Mori, I, Nishiyama, Y.
  • 雑誌名: Current Topics in Virology (in press)
• [雑誌論文] Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide. (2007)
  • 著者名/発表者名: Luo, C., Nawa, A., Yamauchi, Y., et al.
  • 雑誌名: Virus Genes (in press)
• [雑誌論文] Simultaneous quantification of Epstein-Barr virus, Cytomegalovirus, and human Herpesvirus 6 DNA in transplant recipients by multiplex real-time PCR assay. (2007)
  • 著者名/発表者名: Wada, K., Kubota, N., Ito, Y., et al.
  • 雑誌名: Journal of Clinical Microbiology (in press)
• [雑誌論文] Enhanced efficacy of herpes simplex virus mutant HF10 combined with paclitaxel in peritoneal cancer dissemination models. (2007)
  • 著者名/発表者名: Shimoyama, S., Goshima, F., Teshigahara, O., et al.
  • 雑誌名: Hepato-Gastroenterology (in press)
• [雑誌論文] Suitability of a US3-inactivated HSV mutant(LlBRl) as an oncolytic-virus for pancreatic cancer therpay. (2007)
  • 著者名/発表者名: Kasuya, H., Nishiyama, Y., Nomoto, S., et al.
  • 雑誌名: Cancer Gene Therapy (in press)
• [雑誌論文] Herpes simplex virus US3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo. (2006)
  • 著者名/発表者名: Mori, I., Goshima, F., Watanabe, D., Ito, H., Koide, N., Yoshida, T., Liu, B., Kimura, Y., Yokochi, T., Nishiyama, Y.
  • 雑誌名: Microbes and infection 8 ページ: 1806-1812
  • 査読あり
• [雑誌論文] Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates the viral US3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31. (2006)
  • 著者名/発表者名: Kato, A., Yamamoto, M., Ohno, T., Tanaka, M., Sata, T., Nishiyama,Y., Kawaguchi, Y.
  • 雑誌名: Journal of Virology 80 ページ: 1476-1486
  • 査読あり
• [雑誌論文] Association of two membrane proteins encoded by herpes simplex virus type2, UL11 and UL56. (2006)
  • 著者名/発表者名: Koshizuka, T., Kawaguchi, Y., Goshima, F., Mori, I., Nishiyama, Y.
  • 雑誌名: Virus Genes 32 ページ: 153-163
  • 査読あり
• [雑誌論文] Accessory genes define the relationship between the herpes simplex virus and its host. (2006)
  • 著者名/発表者名: Mori, I., Nishiyama, Y.
  • 雑誌名: Microbes and Infection 8 ページ: 2556-2562
  • 査読あり
• [雑誌論文] Replication-competent herpes simplex virus : a novel and promising modality for cancer therapy. (2006)
  • 著者名/発表者名: Mori, I., Nishiyama, Y.
  • 雑誌名: Current Topics in Virology 5 ページ: 21-30
  • 査読あり
• [雑誌論文] Herpes simplex virus US3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo. (2006)
  • 著者名/発表者名: Mori, I., Goshima, F., Watanabe, D., Ito, H., Koide, N., Yoshida, T., Liu, B., Kimura, Y., Yokochi, T. and Nishiyama, Y.
  • 雑誌名: Microbes and infection 8 ページ: 1806-1812
  • 査読あり
• [雑誌論文] Association of two membrane proteins encoded by herpes simplex virus type2, UL11 and UL56. (2006)
  • 著者名/発表者名: Koshizuka, T., Kawaguchi, Y., Goshima, F., et al.
  • 雑誌名: Virus Genes 32 ページ: 157-167
• [雑誌論文] Latent infection of human herpesvirus 7 in CD4(+)T lymphocytes. (2006)
  • 著者名/発表者名: Miyake, F., Yoshikawa, T., Sun, H., et al.
  • 雑誌名: Journal of Medical Virology 78 ページ: 112-116
• [雑誌論文] Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates the viral US3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31. (2006)
  • 著者名/発表者名: Kato, A., Yamamoto, M., Ohno, T., et al.
  • 雑誌名: Journal of Virology 80 ページ: 1476-1486
• [雑誌論文] Herpes simplex virus US3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo. (2006)
  • 著者名/発表者名: Mori, I., Goshima, F., Watanabe, D., et al.
  • 雑誌名: Microbes and infection 8 ページ: 1806-1812
• [雑誌論文] Epstein-barr virus protein kinase BGLF4 is a virion tegument protein that dissociates from virions in a phosphorylation dependent process and phosphorylates the viral innediate-early protein BZLF1. (2006)
  • 著者名/発表者名: Asai, R., Kato, A., Kato, K., et al.
  • 雑誌名: Journal of Virology 80 ページ: 5125-5134
• [雑誌論文] Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection. (2006)
  • 著者名/発表者名: Shibata, Y., Hoshino, Y., Hara, S., et al.
  • 雑誌名: Journal of Medical Virology 78 ページ: 770-779
• [雑誌論文] Intratumoral injection of herpes simplex virus HF10 in recurrent head and neck squamous cell carcinoma. (2006)
  • 著者名/発表者名: Fujimoto, Y., Mizuno, T., Sugiura, S., et al.
  • 雑誌名: Acta Oto-Laryngologia 126 ページ: 1115-1117
• [雑誌論文] Pilot study of oncolytic viral therapy using mutant herpes simplex virus HF10 against recurrent metastatic breast cancer. (2006)
  • 著者名/発表者名: Kimata, H., Imai, T., Kikumori, T., et al.
  • 雑誌名: Annals of Surgical Oncology 13 ページ: 1078-1084
• [雑誌論文] Rapid detection of Epstein-Barr virus DNA by loop-mediated isothermal amplification method. (2006)
  • 著者名/発表者名: Iwata S, Shibata Y, Kawada J, et al.
  • 雑誌名: Journal of Clinical Virology 37 ページ: 128-133
• [雑誌論文] Establishment of a novel foreign gene delivery system combining an HSV amplicon with an attenuated replication-competent virus, HSV-1 HF10. (2006)
  • 著者名/発表者名: Zhang L, Daikoku T, Ohtake K, et al.
  • 雑誌名: Journal of Virological Methods 137 ページ: 177-183
• [学会発表] HSV内耳感染モデルにおけるアポトーシス誘導と内耳機能障害についての検討 (2010)
  • 著者名/発表者名: 江崎伸一、五島典、木村宏、村上信吾、西山幸廣
  • 学会等名: 第58回日本ウイルス学会学術集会
  • 発表場所: あわぎんホール(徳島)
  • 年月日: 2010-11-09
• [学会発表] 単純ヘルペスウイルス1型(HSV-1)のアクセサリー遺伝子UL21の機能解析 (2010)
  • 著者名/発表者名: 武藤義文、牛島洋子、山内洋平、西山幸廣
  • 学会等名: 第58回日本ウイルス学会学術集会
  • 発表場所: あわぎんホール(徳島)
  • 年月日: 2010-11-07
• [学会発表] 単純ヘルペス1型感染後期におけるUL14の遺伝子産物の役割 (2009)
  • 著者名/発表者名: 太田茜、山内洋平、武藤義文、西山幸廣
  • 学会等名: 第57回日本ウイルス学会学術集会
  • 発表場所: 東京
  • 年月日: 2009-10-25
• [学会発表] HSV-2感染によるNedd4ファミリーユビキチンリガーゼの変化とUL56遺伝子産物の役割 (2009)
  • 著者名/発表者名: 牛島洋子、駱晨虹、鎌倉真紀、五島典、西山幸廣
  • 学会等名: 第57回日本ウイルス学会学術集会
  • 発表場所: 東京
  • 年月日: 2009-10-25
• [備考]
  • URL: http://www.med.nagoya-u.ac.jp/virus